Manage nail infections lasting more than 6 weeks by avoiding irritants, prolonged water exposure, and nail trauma. First-line treatments include topical hydrocortisone 1% ointment applied daily for up to 3 weeks, and warm soaks with water, Burow’s Solution, or vinegar. For refractory cases, calcineurin inhibitors like tacrolimus 0.1% are effective, with surgery considered only for persistent cases.
January 14, 2025

Chronic Nailbed Infections: At-Home Doctor-Recommended Treatment

Evidence-Based Over-The-Counter Guide

William Shen

William Shen

Co-founder & CPO

See all guides. Have more questions?

Chronic paronychia is an infection of the skin surrounding the nail lasting more than 6 weeks, often caused by bacteria or fungi. It can be acute (usually bacterial) or chronic (often fungal). Treatment focuses on reducing infection, managing pain, and addressing the underlying cause.

First-line recommendations:

  • Avoidance of irritants and finger trauma: use hypoallergenic products, dye and perfume free, avoid prolonged water exposure, and avoid nail trauma

  • Hydrocortisone cream: Topical steroids are the standard recommendation for chronic paronychia. Use hydrocortisone 1% ointment (FDA M017) on the affected area daily for up to 3 weeks.

Second-line recommendations:

  • Warm soaks: Soak the affected finger or toe in warm water 2-4 times daily for 15-20 minutes to reduce swelling and promote drainage. Alternatively, soaking with Burow’s Solution or 1:1 dilution of white vinegar and water has additional antimicrobial benefits.

  • Zinc supplementation: Zinc deficiency is known to cause soft and fragile nails, nail plate abnormalities, and chronic paronychia. 20 mg zinc daily supplements have been observed to improve symptoms. 

Prescription medications:

  • Calcineuron inhibitors: Anti-inflammatory medications that have shown to be superior for chronic paronychia than animicrobials. In a randomized, unblinded, comparative study, tacrolimus 0.1% (Protopic) was more effective than betamethasone 17-valerate 0.1%.

  • Oral antibiotics: No longer part of general management; only used in specific circumstances.

  • Surgery: Proximal nail fold and nail plate excision may be indicated in refractory cases

Citation

Leggit, J. C. (2017). Acute and chronic paronychia. American family physician, 96(1), 44-51.

Iorizzo M. Tips to treat the 5 most common nail disorders: brittle nails, onycholysis, paronychia, psoriasis, onychomycosis. Dermatol Clin. 2015;33(2):175-183.

What OTC evidence is reviewed?

  • For each condition, we performed a literature review to find a recent widely cited expert group guideline published in the leading specialty-specific peer-reviewed journal or top general medical journal.

  • Based on the recommendations in the publication, we identify recommended active ingredients and devices that are available over-the-counter per FDA regulations.

What evidence is prioritized?

Levels of evidence considered:

  • Tier 1 (Safe and Definitely Effective): Professional field consensus or multiple randomized controlled clinical trials showing the same conclusion. Wherever possible, we use Tier 1 evidence for "first-line" recommendations.

  • Tier 2 (Safe and Probably Effective): Individual clinical trials which may be discordant or large-scale observational experience. Tier 2 evidence may inform "first-line", "second-line", or "supplement" recommendations.

  • Tier 3 (Safe and Maybe Effective): Mechanistic plausibility without high-quality clinical evidence of efficacy but high-quality evidence of safety. Tier 3 evidence may inform "second-line" or "supplement" recommendations.

How does MDandMe select recommended products?

  • Based on the top clinical recommendation, we evaluate products containing the recommended active agent with FDA-approved dosage based on price, average customer reviews, how often it is purchased, and how quickly it will ship to home. 

  • We provide public documentation of the active ingredients in our recommendations, using all 32 FDA monographs, Prescription-to-Nonprescription (Rx-to-OTC) Switches, as well as New Drug Application (NDA) approvals.

How does MDandMe select recommended devices?

  • Based on the top clinical recommendation, we evaluate devices that are FDA-cleared or comply with other medical guidelines (if not a FDA-regulated category) by reputability, price, and average customer reviews.

  • We provide public documentation of supporting evidence for each device.