Treat acute paronychia with warm soaks (plain, Burow’s solution, or 1:1 white vinegar-water mixture) 2–4 times daily to reduce swelling and promote drainage. Apply an antibiotic ointment like bacitracin-polymyxin B (Polysporin) and hydrocortisone 1% cream after each soak to enhance healing and reduce inflammation. For severe cases with abscess or spreading cellulitis, prescription antibiotics or professional incision and drainage may be necessary.
January 11, 2025

Acute Nailbed Infection Solutions

Evidence-Based Over-the-Counter Guide

William Shen

William Shen

Co-founder & CPO

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Acute paronychia is an infection of the skin surrounding the nail lasting less than 6 weeks, often caused by bacteria or fungi. It can be acute (usually bacterial) or chronic (often fungal). Treatment focuses on reducing infection, managing pain, and addressing the underlying cause.

First-line recommendations:

  • Warm soaks: Soak the affected finger or toe in warm water 2-4 times daily for 15-20 minutes to reduce swelling and promote drainage. Alternatively, soaking with Burow’s Solution or 1:1 dilution of All natural distilled white vinegar and water has additional antimicrobial benefits.

  • Antibiotic ointment: Apply to the infected area 2-3 times daily after soaking. bacitracin/neomycin/polymyxin B (Neomycin Antibiotic Ointment) is a popular over-the-counter antibiotic ointment but has been found to cause allergic skin reactions in 10% of people. Alternatively, a bacitracin-polymyxin B combination (Polysporin Antibiotic Skin Ointment) can be used.

  • Hydrocortisone cream: Addition of topical steroids has been shown in randomized double-blind clinical trials to decrease the time to symptom resolution without additional risks. Use hydrocortisone 1% and apply along with antibiotic ointment. Hydrocortisone 1% cream.

Prescription medications:

  • Prescription antibiotic ointment: Mupirocin, gentamicin, or floroquinolones for broader coverage or specific organisms. 

  • Oral antibiotics (e.g., cephalexin or clindamycin): For severe cases with spreading cellulitis or abscess formation.

Professional procedures:

  • Incision and drainage: May be needed for abscess formation, performed by a healthcare professional.

Citation

Leggit, J. C. (2017). Acute and chronic paronychia. American family physician, 96(1), 44-51.

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