Medical guideline recommended over-the-counter approach to hay fever (allergic rhinitis)
January 9, 2025

Nasal Allergies: ARIA International Guidelines

Evidence-Based Over-The-Counter Guide

William Shen

William Shen

Co-founder & CPO

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Nasal allergies (or hay fever, pollen allergies, dust allergies, etc.) are medically known as "allergic rhinitis". The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines were initiated during a World Health Organization workshop in 1999.

Per the ARIA guidelines 2018 update, intranasal corticosteroids are recommended as the primary treatment for patients with moderate-to-severe and/or persistent allergic rhinitis due to their efficacy in controlling nasal symptoms. Antihistamines can be taken orally or intranasally if preferred or if insufficient control is achieved with intranasal corticosteroids.

First-line recommendations:

  • Fluticasone: Intranasal corticosteroid spray, as needed or 2 sprays in each nostril per day. Dose: 0.05% (50 mcg/spray). Buy Fluticasone 0.05% 50mcg (FDA NDA 205434). 

Second-line recommendations:

  • Azelestine: Intranasal antihistamine spray, as needed or 2 sprays in each nostril per day. Dose: 0.1% (137 mcg/spray). Buy azelestine 0.1% 137 mcg (FDA NDA 213872). 

  • Loratidine: Second-generation oral antihistamine. Dose: Adults and children ≥ 6 years: loratadine 10 mg orally once daily. Buy loratadine 10 mg (FDA NDA 19658/S-020).

Prescription medications:

Decongestants and more advanced immunomodulatory medications such as leukotriene receptor antagonists may be prescribed for severe cases.

Citations:

Bousquet, J., Schünemann, H. J., Togias, A., et al. (2020). Next-generation Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. Allergy, 75(8), 2041-2052.

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  • For each condition, we performed a literature review to find a recent widely cited expert group guideline published in the leading specialty-specific peer-reviewed journal or top general medical journal.

  • Based on the recommendations in the publication, we identify recommended active ingredients and devices that are available over-the-counter per FDA regulations.

What evidence is prioritized?

Levels of evidence considered:

  • Tier 1 (Safe and Definitely Effective): Professional field consensus or multiple randomized controlled clinical trials showing the same conclusion. Wherever possible, we use Tier 1 evidence for "first-line" recommendations.

  • Tier 2 (Safe and Probably Effective): Individual clinical trials which may be discordant or large-scale observational experience. Tier 2 evidence may inform "first-line", "second-line", or "supplement" recommendations.

  • Tier 3 (Safe and Maybe Effective): Mechanistic plausibility without high-quality clinical evidence of efficacy but high-quality evidence of safety. Tier 3 evidence may inform "second-line" or "supplement" recommendations.

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  • Based on the top clinical recommendation, we evaluate products containing the recommended active agent with FDA-approved dosage based on price, average customer reviews, how often it is purchased, and how quickly it will ship to home. 

  • We provide public documentation of the active ingredients in our recommendations, using all 32 FDA monographs, Prescription-to-Nonprescription (Rx-to-OTC) Switches, as well as New Drug Application (NDA) approvals.

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  • Based on the top clinical recommendation, we evaluate devices that are FDA-cleared or comply with other medical guidelines (if not a FDA-regulated category) by reputability, price, and average customer reviews.

  • We provide public documentation of supporting evidence for each device.