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Medical guideline recommended over-the-counter approach to hay fever (allergic rhinitis)
January 9, 2025

Nasal Allergies: ARIA International Guidelines

Evidence-Based Over-The-Counter Guide

William Shen

William Shen

Co-founder & CPO

See all guides. Have more questions?

Nasal allergies (or hay fever, pollen allergies, dust allergies, etc.) are medically known as "allergic rhinitis". The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines were initiated during a World Health Organization workshop in 1999.

Per the ARIA guidelines 2018 update, intranasal corticosteroids are recommended as the primary treatment for patients with moderate-to-severe and/or persistent allergic rhinitis due to their efficacy in controlling nasal symptoms. Antihistamines can be taken orally or intranasally if preferred or if insufficient control is achieved with intranasal corticosteroids.

First-line recommendations:

  • Fluticasone: Intranasal corticosteroid spray, as needed or 2 sprays in each nostril per day. Dose: 0.05% (50 mcg/spray). Buy Fluticasone 0.05% 50mcg (FDA NDA 205434). 

Second-line recommendations:

  • Azelestine: Intranasal antihistamine spray, as needed or 2 sprays in each nostril per day. Dose: 0.1% (137 mcg/spray). Buy azelestine 0.1% 137 mcg (FDA NDA 213872). 

  • Loratidine: Second-generation oral antihistamine. Dose: Adults and children ≥ 6 years: loratadine 10 mg orally once daily. Buy loratadine 10 mg (FDA NDA 19658/S-020).

Prescription medications:

Decongestants and more advanced immunomodulatory medications such as leukotriene receptor antagonists may be prescribed for severe cases.

Citations:

Bousquet, J., Schünemann, H. J., Togias, A., et al. (2020). Next-generation Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. Allergy, 75(8), 2041-2052.

What OTC evidence is reviewed?

  • For each condition, we performed a literature review to find a recent widely cited expert group guideline published in the leading specialty-specific peer-reviewed journal or top general medical journal.

  • Based on the recommendations in the publication, we identify recommended active ingredients and devices that are available over-the-counter per FDA regulations.

What evidence is prioritized?

Levels of evidence considered:

  • Tier 1 (Safe and Definitely Effective): Professional field consensus or multiple randomized controlled clinical trials showing the same conclusion. Wherever possible, we use Tier 1 evidence for "first-line" recommendations.

  • Tier 2 (Safe and Probably Effective): Individual clinical trials which may be discordant or large-scale observational experience. Tier 2 evidence may inform "first-line", "second-line", or "supplement" recommendations.

  • Tier 3 (Safe and Maybe Effective): Mechanistic plausibility without high-quality clinical evidence of efficacy but high-quality evidence of safety. Tier 3 evidence may inform "second-line" or "supplement" recommendations.

How does MDandMe select recommended products?

  • Based on the top clinical recommendation, we evaluate products containing the recommended active agent with FDA-approved dosage based on price, average customer reviews, how often it is purchased, and how quickly it will ship to home. 

  • We provide public documentation of the active ingredients in our recommendations, using all 32 FDA monographs, Prescription-to-Nonprescription (Rx-to-OTC) Switches, as well as New Drug Application (NDA) approvals.

How does MDandMe select recommended devices?

  • Based on the top clinical recommendation, we evaluate devices that are FDA-cleared or comply with other medical guidelines (if not a FDA-regulated category) by reputability, price, and average customer reviews.

  • We provide public documentation of supporting evidence for each device.  

Where do I view other OTC guides?

Browse topic list here:

  • Acne

  • Acid Reflux

  • Allergies (Nasal)

  • Allergies (Itchy Eyes)

  • Allergic Skin Rash

  • Ankle Sprain

  • Arthritis (Osteoarthritis)

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  • GERD

  • Glue Ear

  • Gum Bleeding (Gingivitis)

  • Hair Loss

  • Hay Fever

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  • Hearing Loss

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  • Migraines

  • Morning Sickness (Pregnancy)

  • Motion Sickness

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  • Nailbed Infection (Chronic)

  • Nasal Allergies

  • Orthostatic Hypotension

  • Period Pain

  • Peripheral Neuropathy

  • Pinworm

  • Post-Nasal Drip

  • POTS

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  • Yeast Infection (Vaginal)

You can view all of our published OTC guides here.

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