[43F] With rash, fatigue, hair loss, and cold extremities

Patient Description

A 43-year-old female presents with a sudden onset of an itchy rash persisting for 4 days, located on the middle section of her arms, back of one leg, under her breast, and lower stomach. The rash consists of small, raised, red to skin-colored bumps and is intensely itchy, with the itch occurring more frequently over time. The patient has applied cream and taken Benadryl with no significant relief. In addition to the rash, she reports chronic symptoms over the past 3 years, including persistent fatigue, significant hair loss during hair washing, decreased libido, cold extremities, occasional ankle swelling, blurry vision, and memory loss. There is a family history of autoimmune disorders, including lupus and Graves' disease, as well as circulation problems and brain tumors in her parents. The patient has not been evaluated for autoimmune conditions or undergone thyroid function tests. She has maintained a stable weight for the past 20 years, with no significant changes despite diet variations. No known allergies or current medications reported.

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Arora's Assessment

What might be happening

Based on the symptoms you've described and your family history, here are some possibilities:

  1. Autoimmune Condition: Your symptoms, including fatigue, hair loss, cold extremities, and rash, along with a family history of lupus and Graves' disease, suggest the possibility of an autoimmune condition. Autoimmune diseases occur when the immune system mistakenly attacks the body's own tissues. Lupus, for example, can cause a variety of symptoms, including skin rashes, fatigue, and hair loss.

  2. Thyroid Dysfunction: Symptoms like fatigue, hair loss, cold extremities, and occasional ankle swelling could be related to thyroid dysfunction, such as hypothyroidism. This condition occurs when the thyroid gland doesn't produce enough hormones, leading to symptoms like fatigue, weight changes, and hair loss. Given your family history of Graves' disease, which affects the thyroid, it's worth considering thyroid testing.

  3. Contact Dermatitis or Eczema: The sudden onset of an itchy rash could be due to contact dermatitis, which is a skin reaction to an irritant or allergen. Eczema (atopic dermatitis) is another possibility, which is a chronic skin condition that causes itchy, inflamed skin.

What you can do

Rash:

  • Avoid scratching the rash to prevent further irritation or infection.
  • Continue using over-the-counter antihistamines like Benadryl to help with itching.
  • Apply a soothing lotion or cream, such as calamine lotion or hydrocortisone cream, to reduce itching and inflammation.
  • If the rash persists or worsens, consult a healthcare provider for further evaluation and treatment.

Fatigue, Hair Loss, and Cold Extremities:

  • Schedule an appointment with a healthcare provider to discuss your symptoms and consider testing for autoimmune conditions and thyroid function.
  • Maintain a balanced diet rich in vitamins and minerals to support overall health.
  • Manage stress through relaxation techniques, such as meditation or yoga, which may help alleviate some symptoms.

Blurry Vision and Memory Loss:

  • Keep track of when these symptoms occur and any potential triggers.
  • Discuss these symptoms with your healthcare provider, as they may be related to an underlying condition.

General Health:

  • Use MDandMe to journal your symptoms, track progress, and share insights with your healthcare provider.
  • Stay hydrated and get adequate rest to support your body's healing process.

What you should look out for

  • Severe or Sudden Onset of Symptoms: If you experience a sudden and severe worsening of your symptoms, such as intense pain, swelling, or a rash that rapidly spreads, seek medical attention.
  • Neurological Symptoms: If you experience sudden confusion, difficulty speaking, severe headache, or weakness on one side of your body, seek immediate medical care.
  • Signs of Infection: High fever, chills, or a rash accompanied by other systemic symptoms may indicate an infection that requires prompt treatment.

Remember, it's important to consult with a healthcare provider for a formal diagnosis and appropriate treatment. If you have any more questions or need further assistance, feel free to ask!

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9 d ago

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People Also Ask


What could be causing my sudden itchy rash?

Your sudden itchy rash could be caused by contact dermatitis, which is a reaction to an irritant or allergen, or it could be eczema, a chronic skin condition. It's important to avoid scratching and consider using soothing creams or antihistamines. If the rash persists, consult a healthcare provider.


Could my symptoms be related to an autoimmune condition?

Yes, your symptoms, such as fatigue, hair loss, and cold extremities, along with a family history of autoimmune disorders, suggest the possibility of an autoimmune condition. Conditions like lupus can cause a variety of symptoms, and it's advisable to get evaluated by a healthcare provider.


How can thyroid dysfunction affect my health?

Thyroid dysfunction, such as hypothyroidism, can lead to symptoms like fatigue, hair loss, cold extremities, and swelling. It occurs when the thyroid gland doesn't produce enough hormones, affecting your metabolism and overall health. Testing for thyroid function can help diagnose this condition.


What steps should I take if my symptoms persist or worsen?

If your symptoms persist or worsen, it's important to consult a healthcare provider for further evaluation. They may recommend tests for autoimmune conditions and thyroid function. Keep track of your symptoms, maintain a healthy lifestyle, and seek medical attention if you experience severe or sudden symptoms.


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