[24F] Experiencing heart rhythm changes post-Zoloft discontinuation

Patient Description

A 24-year-old female reports experiencing a sensation of her heart rhythm like a wave through her upper chest to her head, accompanied by shortness of breath. These symptoms began after discontinuing Zoloft, as advised by her psychiatrist, and occur mostly with movement, lasting throughout the day. The patient also experiences some dizziness but no headaches, mood changes, or anxiety since stopping Zoloft. She is currently taking propranolol (10 mg), bupropion (150 mg), and oral contraceptives. The patient has a high pulse but no history of high blood pressure or other heart-related conditions, although her father has high blood pressure and a leaky valve. She has no known allergies or adverse reactions to medications.

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Arora's Assessment

What might be happening

Based on the information you've provided, here are some possible explanations for your symptoms:

  1. Withdrawal from Zoloft (Sertraline): Stopping Zoloft, especially if done abruptly, can lead to withdrawal symptoms, sometimes referred to as "discontinuation syndrome." Symptoms can include dizziness, changes in heart rhythm, and shortness of breath. These symptoms usually resolve over time as your body adjusts.

    • Treatment typically involves monitoring symptoms and, if necessary, consulting with your healthcare provider about possibly restarting the medication at a lower dose and tapering off more gradually.
  2. Propranolol Effects: Propranolol is a beta-blocker that can affect heart rate and rhythm. While it is often used to manage high pulse rates, it can sometimes cause side effects like dizziness or changes in how you perceive your heart rhythm.

    • If propranolol is contributing to your symptoms, your doctor might adjust the dosage or consider alternative medications.
  3. Anxiety or Stress: Even if you haven't noticed changes in mood, the physical symptoms of anxiety can sometimes manifest as changes in heart rhythm or shortness of breath, especially during periods of stress or medication changes.

    • Techniques such as deep breathing exercises, mindfulness, or relaxation techniques can be helpful.

What you can do

  1. Consult Your Healthcare Provider: It's important to discuss these symptoms with your doctor, especially since they started after stopping Zoloft. They can provide guidance on managing withdrawal symptoms or adjusting your current medications.

  2. Monitor Your Symptoms: Keep track of when these symptoms occur, their duration, and any potential triggers. This information can be valuable for your healthcare provider. You can use MDandMe to journal your symptoms, track progress, and share insights with your provider.

  3. Stay Hydrated and Rested: Ensure you're drinking enough water and getting adequate rest, as dehydration and fatigue can exacerbate symptoms.

  4. Avoid Sudden Movements: Since your symptoms occur mostly when moving around, try to move slowly and deliberately to minimize dizziness and changes in heart rhythm.

What you should look out for

Seek medical attention if you experience:

  • Severe or worsening shortness of breath
  • Chest pain or pressure
  • Fainting or severe dizziness
  • Any new or concerning symptoms

Remember, while this information can be helpful, it's important to consult with a healthcare professional for a formal diagnosis and personalized treatment plan.

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28 d ago


People Also Ask


What are common withdrawal symptoms after stopping Zoloft?

Common withdrawal symptoms from Zoloft can include dizziness, changes in heart rhythm, shortness of breath, irritability, and flu-like symptoms. These usually resolve over time as your body adjusts.


How can propranolol affect heart rhythm and what should I watch out for?

Propranolol can slow down the heart rate and may cause dizziness or changes in heart rhythm. If you experience severe dizziness, fainting, or a very slow heart rate, you should contact your healthcare provider.


Can anxiety cause physical symptoms like changes in heart rhythm or shortness of breath?

Yes, anxiety can manifest physically with symptoms such as changes in heart rhythm, shortness of breath, and dizziness, even if you don't feel anxious. Stress management techniques can help alleviate these symptoms.


What steps can I take to manage dizziness and shortness of breath after stopping medication?

To manage dizziness and shortness of breath, stay hydrated, rest adequately, avoid sudden movements, and monitor your symptoms. Consult your healthcare provider for personalized advice and possible medication adjustments.

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