[20F] Missed Depo shot with subsequent symptoms

Patient Description

A 20-year-old female missed her scheduled Depo-Provera shot on May 2nd of this year. She experienced light spotting for two days in May and has not had her period since. She took a pregnancy test almost two weeks ago, which came back negative. Over the past two weeks, she has been experiencing nausea, fatigue, sharp and sometimes crampy abdominal pain, and diarrhea. She has been under personal life stress recently but has not experienced any significant weight changes, breast tenderness, or vomiting. She has not traveled recently, made significant changes to her diet, or been exposed to sick individuals or new medications. No pre-existing conditions or chronic illnesses were reported, and she is not currently taking any medications.

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Arora's Assessment

What might be happening

Based on the information you've provided, here are some possible explanations for your symptoms:

Missed Depo Shot and Pregnancy Concerns

  • Pregnancy: Missing your Depo-Provera shot and having unprotected sex increases the risk of pregnancy. Although your pregnancy test was negative, it might have been taken too early. Pregnancy tests are most accurate when taken after a missed period.
  • Hormonal Imbalance: Missing your Depo shot can cause hormonal fluctuations, leading to symptoms like nausea, fatigue, and irregular bleeding.

Abdominal Pain and Diarrhea

  • Gastrointestinal Issues: Sharp and crampy abdominal pain along with diarrhea could indicate a gastrointestinal issue such as an infection, irritable bowel syndrome (IBS), or food intolerance.
  • Stress: High levels of stress can also contribute to gastrointestinal symptoms, including nausea, abdominal pain, and diarrhea.

What you can do

Pregnancy Concerns

  • Retake a Pregnancy Test: Consider retaking a pregnancy test, especially if more time has passed since your missed period. Tests are more accurate when taken a week after a missed period.
  • Consult a Healthcare Provider: Schedule an appointment with your healthcare provider to discuss your missed Depo shot and your symptoms. They may recommend a blood test for pregnancy or other evaluations.

Abdominal Pain and Diarrhea

  • Stay Hydrated: Drink plenty of fluids to stay hydrated, especially if you are experiencing diarrhea.
  • Dietary Adjustments: Eat a bland diet (e.g., bananas, rice, applesauce, toast) to help manage diarrhea and avoid foods that can irritate your stomach.
  • Over-the-Counter Medications: Consider using over-the-counter medications like antacids or anti-diarrheal agents, but consult with a healthcare provider first.

Stress Management

  • Relaxation Techniques: Practice relaxation techniques such as deep breathing, meditation, or yoga to help manage stress.
  • Seek Support: Talk to a trusted friend, family member, or mental health professional about your stressors.

General Advice

  • Track Symptoms: Use MDandMe to journal your symptoms, track progress, get insights, and share longitudinal medical notes with your provider. This can help in identifying patterns and making informed decisions about your health.

What you should look out for

Given the complexity of your symptoms, it's important to seek medical care if you experience any of the following:

  • Severe Abdominal Pain: If the pain becomes severe or unbearable.
  • Persistent Vomiting: If you start vomiting or if nausea worsens.
  • Signs of Dehydration: Such as dry mouth, dark urine, or dizziness.
  • Positive Pregnancy Test: If a subsequent pregnancy test comes back positive, seek prenatal care immediately.

Remember, while I can provide guidance, it's crucial to consult with a healthcare professional for a formal diagnosis and appropriate treatment. If you have more questions or need further assistance, feel free to continue the conversation.

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4 mo ago


People Also Ask


Can missing a Depo-Provera shot cause symptoms like nausea and fatigue?

Yes, missing a Depo-Provera shot can lead to hormonal imbalances, which may cause symptoms such as nausea, fatigue, and irregular bleeding.


How soon after a missed period should I take a pregnancy test for accurate results?

Pregnancy tests are most accurate when taken at least a week after a missed period. If the initial test was negative and your period is still absent, consider retaking the test.


What are some common causes of sharp abdominal pain and diarrhea?

Sharp abdominal pain and diarrhea can be caused by gastrointestinal issues such as infections, irritable bowel syndrome (IBS), or food intolerances. Stress can also exacerbate these symptoms.


How can stress affect my gastrointestinal health?

Stress can impact gastrointestinal health by causing symptoms like nausea, abdominal pain, and diarrhea. It can affect digestion and lead to conditions like irritable bowel syndrome (IBS).


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