[47F] With redness in knees and feet, and history of high blood pressure

Patient Description

A 47-year-old female has been experiencing bright redness in her big toes and kneecaps after standing for a while, and her feet turn purple when she crosses her legs. These symptoms have been present for a few months and are alleviated by elevating her legs or resting. She also experiences coldness in her legs and feet but denies any swelling, pain, numbness, tingling, or other changes in skin color. There are no sores or ulcers that are slow to heal, and no hair loss on her legs or feet. The patient has a history of high blood pressure, which is managed with lisinopril 10 mg, and a recent diagnosis of a blood clot in her arm. She has a history of smoking and does not have any known drug allergies or take any other medications, supplements, or herbal remedies.

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Arora's Assessment

What might be happening

Based on the information you've provided, here are some possible explanations for your symptoms:

Peripheral Artery Disease (PAD)

  • Rationale: PAD is a condition where the arteries that supply blood to your limbs become narrowed or blocked. This can cause symptoms like redness, coldness, and discoloration in your legs and feet, especially after standing or crossing your legs. The fact that your symptoms improve with elevation and rest further supports this possibility.
  • Typical Treatments/Testing: Diagnosis often involves a physical exam, blood tests, and imaging studies like an ankle-brachial index (ABI) test, ultrasound, or angiography. Treatment may include lifestyle changes, medications to improve blood flow, and in severe cases, surgical interventions.

Venous Insufficiency

  • Rationale: This condition occurs when the veins in your legs have trouble sending blood back to your heart. This can lead to symptoms like redness, swelling, and discoloration, especially after prolonged standing. The improvement of symptoms with elevation is also consistent with this condition.
  • Typical Treatments/Testing: Diagnosis usually involves a physical exam and possibly a Doppler ultrasound to assess blood flow in your veins. Treatment may include compression stockings, medications, and lifestyle changes. In some cases, surgical procedures may be necessary.

Blood Clot (Deep Vein Thrombosis - DVT)

  • Rationale: Given your recent diagnosis of a blood clot in your arm, it's important to consider the possibility of a blood clot in your legs. DVT can cause redness, swelling, and pain in the affected limb. While you haven't mentioned swelling or pain, the discoloration and coldness could still be related.
  • Typical Treatments/Testing: Diagnosis typically involves a physical exam, blood tests (like D-dimer), and imaging studies such as an ultrasound. Treatment usually includes anticoagulant medications to prevent the clot from growing and to reduce the risk of complications.

What you can do

Peripheral Artery Disease (PAD)

  • Consult a Doctor: It's important to see a healthcare provider for a proper diagnosis and treatment plan. They may recommend lifestyle changes, medications, or procedures to improve blood flow.
  • Lifestyle Changes: Quit smoking, maintain a healthy diet, and engage in regular physical activity to improve circulation.
  • Symptom Tracking: Use MDandMe to journal your symptoms, track progress, and share your notes with your healthcare provider.

Venous Insufficiency

  • Consult a Doctor: A healthcare provider can help diagnose and manage this condition. They may recommend compression stockings, medications, or procedures to improve blood flow.
  • Elevate Your Legs: Elevate your legs when resting to help reduce symptoms.
  • Symptom Tracking: Use MDandMe to journal your symptoms, track progress, and share your notes with your healthcare provider.

Blood Clot (DVT)

  • Seek Immediate Medical Attention: If you suspect a blood clot, it's crucial to seek medical attention immediately. This condition can be life-threatening if not treated promptly.
  • Follow Treatment Plan: If diagnosed with DVT, follow your healthcare provider's treatment plan, which may include anticoagulant medications.
  • Symptom Tracking: Use MDandMe to journal your symptoms, track progress, and share your notes with your healthcare provider.

What you should look out for

Given the potential seriousness of your symptoms, it's important to seek medical care as soon as possible. Reasons to seek care even more urgently include:

  • Sudden or Severe Pain: If you experience sudden or severe pain in your legs or feet, seek immediate medical attention.
  • Swelling: If you notice swelling in your legs or feet, especially if it's accompanied by pain or redness, seek medical care.
  • Shortness of Breath or Chest Pain: These could be signs of a blood clot traveling to your lungs (pulmonary embolism) and require immediate medical attention.
  • Changes in Skin Color: If you notice any new or worsening changes in skin color, such as increased redness, purple discoloration, or paleness, seek medical care.

Remember, while I can provide information and suggestions, it's important to consult with a healthcare professional for a formal diagnosis and treatment plan. If you have any more questions or need further assistance, feel free to continue the conversation.

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7 mo ago

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People Also Ask


What are the common symptoms of Peripheral Artery Disease (PAD)?

Common symptoms of Peripheral Artery Disease (PAD) include leg pain or cramping during physical activities, coldness in the lower leg or foot, sores or wounds on toes, feet, or legs that heal slowly, and changes in skin color or temperature.


How is venous insufficiency diagnosed and treated?

Venous insufficiency is typically diagnosed through a physical exam and imaging tests like a Doppler ultrasound to assess blood flow in the veins. Treatment may include wearing compression stockings, taking medications to improve blood flow, and making lifestyle changes. In some cases, surgical procedures may be necessary.


What are the risks associated with untreated Deep Vein Thrombosis (DVT)?

Untreated Deep Vein Thrombosis (DVT) can lead to serious complications such as a pulmonary embolism, where a blood clot travels to the lungs, causing chest pain, shortness of breath, and potentially life-threatening conditions. It can also cause long-term complications like post-thrombotic syndrome, leading to chronic pain and swelling.


How can lifestyle changes help manage symptoms of PAD and venous insufficiency?

Lifestyle changes such as quitting smoking, maintaining a healthy diet, and engaging in regular physical activity can improve circulation and help manage symptoms of PAD and venous insufficiency. Elevating the legs and using compression stockings can also alleviate symptoms.


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