[53M] With painful red blotches on calves, knee swelling, and numbness

What might be happening

Based on the symptoms you've described, there are a few serious conditions that could be causing your symptoms:

1. Deep Vein Thrombosis (DVT): This is a blood clot that forms in a deep vein, usually in the legs. Symptoms can include swelling, pain, and red or discolored skin. Given your family history of stroke and heart attack, and the fact that you smoke, you may be at higher risk for DVT. Immediate medical attention is crucial as a clot can travel to the lungs, causing a life-threatening condition called a pulmonary embolism.

2. Cellulitis: This is a bacterial skin infection that can cause red, swollen, and painful areas on the skin. It can spread rapidly and may require antibiotics. The sudden appearance of red blotches and swelling could be indicative of this condition.

3. Peripheral Artery Disease (PAD): This condition involves the narrowing of the arteries, which reduces blood flow to the limbs. Symptoms can include leg pain, numbness, and changes in skin color. Smoking is a significant risk factor for PAD.

4. Compartment Syndrome: This is a painful condition that occurs when pressure within the muscles builds to dangerous levels. It can decrease blood flow, which prevents nourishment and oxygen from reaching nerve and muscle cells. The firm swelling and pain in your knee could be a sign of this condition.

What you can do

1. Seek Immediate Medical Attention: Given the seriousness of the potential conditions, you should seek immediate medical attention. Go to the nearest emergency room or urgent care center. If you are unable to get there yourself, call 911 or have someone drive you.

2. Avoid Further Strain: Try to keep off your feet as much as possible until you can see a healthcare provider. Elevate your legs to reduce swelling.

3. Monitor Symptoms: Keep an eye on your symptoms. If you notice any worsening of the pain, increased swelling, difficulty breathing, or chest pain, seek emergency medical help immediately.

4. Prepare for Your Visit: When you see a healthcare provider, be prepared to discuss your symptoms in detail, including when they started, how they have progressed, and any other relevant information such as your family history and smoking habits.

Remember, I am not a doctor, and this information is not a substitute for professional medical advice. Please seek care from a real health professional to receive a formal diagnosis and appropriate treatment.