[43F] With severe right knee pain and swelling

Patient Description

A 43-year-old female reports experiencing severe, sharp pain in her right knee for about one to two months. The pain is rated as 10 out of 10 in intensity and occurs even while sitting. The onset of pain was sudden, with no recent injuries, falls, or direct trauma to the knee. The patient notes intermittent swelling throughout the day, but no redness or warmth is present. There is a significant family history of joint problems and autoimmune diseases, with the patient's sister having an autoimmune condition and both parents and sister experiencing joint pain. The patient has no prior history of knee issues or treatments. No recent medication changes or infections were reported.

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Arora's Assessment

What might be happening

Based on the information you've provided, here are some possible explanations for your knee pain:

  1. Gout or Pseudogout: These are types of arthritis caused by the accumulation of crystals in the joint, leading to sudden and severe pain, swelling, and inflammation. Gout is due to uric acid crystals, while pseudogout is due to calcium pyrophosphate crystals. Testing typically involves joint fluid analysis and blood tests.

  2. Rheumatoid Arthritis: Given your family history of autoimmune diseases, rheumatoid arthritis could be a possibility. It is an autoimmune condition that causes joint pain and swelling. Diagnosis often involves blood tests for specific antibodies and imaging studies.

  3. Infection (Septic Arthritis): Although you haven't mentioned fever or warmth, an infection in the joint can cause severe pain and swelling. This is a medical emergency and requires immediate attention. Diagnosis involves joint fluid analysis and blood tests.

  4. Meniscus Tear or Ligament Injury: Even without a specific injury, wear and tear or a sudden movement can cause a tear in the knee's cartilage or ligaments, leading to pain and swelling. An MRI is often used for diagnosis.

  5. Osteoarthritis: This is a degenerative joint disease that can cause pain and swelling, especially if you have a family history of joint problems. Diagnosis is typically through physical examination and imaging studies like X-rays.

What you can do

  1. Consult a Healthcare Provider: It's important to see a doctor for a formal diagnosis and appropriate treatment. They may recommend imaging tests or blood work to determine the cause of your symptoms.

  2. Rest and Elevate: Try to rest your knee and keep it elevated to reduce swelling. Avoid activities that worsen the pain.

  3. Ice and Compression: Applying ice packs and using a compression bandage can help manage swelling and pain.

  4. Over-the-Counter Pain Relief: Non-prescription pain relievers like ibuprofen or acetaminophen may help alleviate pain, but consult with a healthcare provider before taking any medication, especially given your low blood platelets.

  5. Use MDandMe: Consider using MDandMe to journal your symptoms, track your progress, and share detailed notes with your healthcare provider.

What you should look out for

  • Seek Immediate Medical Attention: If you develop a fever, notice redness or warmth in the knee, or if the pain becomes unbearable, seek medical care promptly as these could be signs of an infection or other serious condition.

  • Monitor for Changes: Keep an eye on any changes in your symptoms, such as increased swelling or new symptoms, and report these to your healthcare provider.

Remember, while this information can be helpful, it is not a substitute for professional medical advice. Please consult a healthcare provider for a thorough evaluation and personalized treatment plan.

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People Also Ask


What are the common symptoms of gout or pseudogout in the knee?

Common symptoms of gout or pseudogout in the knee include sudden and severe pain, swelling, and sometimes redness. The pain often starts at night and can be intense enough to wake you up. Diagnosis typically involves joint fluid analysis and blood tests.


How is rheumatoid arthritis diagnosed and what are its symptoms?

Rheumatoid arthritis is diagnosed through a combination of blood tests for specific antibodies, such as rheumatoid factor and anti-CCP, and imaging studies like X-rays or MRIs. Symptoms include joint pain, swelling, stiffness, and sometimes systemic symptoms like fatigue and fever.


What are the signs of a meniscus tear or ligament injury in the knee?

Signs of a meniscus tear or ligament injury in the knee include pain, swelling, a popping sensation during the injury, difficulty bending or straightening the knee, and a feeling of the knee giving way. An MRI is often used to confirm the diagnosis.


What lifestyle changes can help manage osteoarthritis symptoms?

Lifestyle changes that can help manage osteoarthritis symptoms include maintaining a healthy weight, engaging in regular low-impact exercise like swimming or cycling, using supportive footwear, and incorporating strength training to support the joints. Additionally, physical therapy and dietary changes to reduce inflammation may be beneficial.


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