[38F] With persistent lymphadenopathy and unexplained weight loss

What might be happening

Based on the information provided, several conditions could be causing your symptoms:

• Lymphoma: This is a type of cancer that begins in the cells of the lymph system. The presence of enlarged, painless lymph nodes, significant weight loss, and night sweats are common symptoms of lymphoma. Fatigue can also be a symptom of lymphoma.

  • Diagnostic tests for lymphoma typically include blood tests, imaging tests, and a lymph node biopsy. Treatment can include chemotherapy, radiation therapy, and other therapies.

• Infections: Certain viral or bacterial infections can cause swollen lymph nodes and fatigue. However, these usually resolve after the infection is treated. Given the duration of your symptoms, this seems less likely but cannot be ruled out without further testing.

  • Treatment would depend on the specific infection, but could include antibiotics or antiviral medications.

• Autoimmune conditions: Certain autoimmune conditions, such as lupus or rheumatoid arthritis, can cause swollen lymph nodes and fatigue. However, these conditions usually present with other symptoms such as joint pain or skin rashes.

  • Treatment typically involves medications to manage symptoms and slow disease progression.

What you can do

Given the duration and severity of your symptoms, it's important to seek medical attention as soon as possible. Here are some steps you can take:

1. Schedule an appointment with your primary care doctor. They can perform a physical examination and order further tests if necessary.
2. Keep track of your symptoms. This can help your doctor determine the cause of your symptoms.
3. Continue taking your prescribed medications as directed.

What you should look out for

Contact your doctor immediately or seek emergency medical attention if you experience any of the following:

• Difficulty breathing or shortness of breath
• Severe pain
• High fever (temperature over 100.4°F)
• Rapid weight loss
• Any new or worsening symptoms

Please remember that while I strive to provide accurate information, I'm not a doctor. It's important to consult with a healthcare professional for an accurate diagnosis and treatment.