[29F] With swollen lymph nodes, fever, and weight loss

Patient Description

A 29-year-old female presents with a 3-month history of non-tender, swollen lymph nodes in the neck, fatigue, recurring low-grade fever, and loss of appetite. The patient reports significant weight loss of 40lbs over the past year, which was unexpected and easier than previous attempts to lose weight. The patient experiences night sweats and a cough, with occasional itching but no rash. There is a history of major depressive disorder and anxiety diagnosed 10 years ago, currently managed with Wellbutrin (150mg) and escitalopram (15mg), without any noted side effects. The patient's family history includes cancer in grandparents, but specifics regarding lymphoma or autoimmune diseases are unknown. The patient has been more active over the past year but has no known drug allergies or adverse reactions to medications.

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Arora's Assessment

What might be happening

Based on the information you've provided, possible diagnoses include:

  • Lymphoma: This is a type of cancer that begins in the lymphatic system. The lymphatic system is part of the body's germ-fighting network. The most common symptom is a painless swelling in a lymph node. Other symptoms can include recurring fever, night sweats, fatigue, and unexplained weight loss.

    • Treatment typically involves chemotherapy, radiation therapy, and in some cases stem cell transplant.
  • Infections: Certain viral and bacterial infections can cause swollen lymph nodes, along with symptoms such as fever, fatigue, and loss of appetite. Examples include mononucleosis, HIV, and tuberculosis.

    • Treatment depends on the specific infection, and can range from antibiotics for bacterial infections to antiviral medications for viral infections.
  • Autoimmune diseases: Conditions such as lupus or rheumatoid arthritis can cause symptoms similar to yours. These conditions occur when your immune system mistakenly attacks your own body tissues.

    • Treatment typically involves medications to reduce inflammation and suppress the immune system.

Please note that this is not an exhaustive list and other conditions could also explain your symptoms.

What you can do

Given the duration and nature of your symptoms, it's important to seek medical attention promptly. Here are some steps you can take:

  1. Schedule an appointment with your primary care provider. If you don't have one, consider going to an urgent care clinic or emergency department.
  2. Write down all of your symptoms, even if they seem unrelated. Also note any personal or family history of medical conditions.
  3. Bring a list of all medications, vitamins, or supplements that you're currently taking.
  4. If possible, bring a friend or family member with you to the appointment. They can help you remember information and ask questions.

What you should look out for

Contact a healthcare provider immediately if you experience:

  • Difficulty breathing or swallowing
  • High fever (over 101°F)
  • Severe night sweats
  • Unexplained weight loss

Remember, while I strive to provide accurate information, I'm not a doctor. Always consult with a healthcare provider for a formal diagnosis and treatment.

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10 mo ago

People Also Ask


What are the common symptoms of lymphoma?

Common symptoms of lymphoma include painless swelling of lymph nodes, recurring fever, night sweats, fatigue, and unexplained weight loss. Other symptoms can include itching and a persistent cough.


Can infections cause swollen lymph nodes and similar symptoms?

Yes, certain infections such as mononucleosis, HIV, and tuberculosis can cause swollen lymph nodes along with symptoms like fever, fatigue, and loss of appetite. Treatment varies depending on the specific infection.


How do autoimmune diseases present with symptoms like swollen lymph nodes and fatigue?

Autoimmune diseases like lupus or rheumatoid arthritis can cause symptoms such as swollen lymph nodes, fatigue, and fever. These conditions occur when the immune system mistakenly attacks the body's own tissues.


What should I do if I experience severe night sweats and unexplained weight loss?

If you experience severe night sweats and unexplained weight loss, it is important to seek medical attention promptly. These could be signs of a serious condition, and a healthcare provider can help determine the cause and appropriate treatment.


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