[36F] With leg swelling, chest pain, and multiple chronic conditions

Patient Description

A 36-year-old female presents with swelling in her legs for the past two months, which becomes firmer throughout the day and improves with leg elevation or after a night's rest. The swelling occurs daily for several hours, with no changes in color or temperature, and no recent weight gain or dietary changes. The patient also reports sharp, burning chest pain with deep pressure, rated 7/10 in severity, exacerbated by standing for more than 15 minutes, walking, or excessive activity, with no relief measures identified. Additionally, she experiences fast, sharp, and painful palpitations. The patient has severe fatigue and increased knee pain for the past three years, described as dull, aching, constant, and affecting mobility, with no history of knee injury. She denies shortness of breath, fever, dizziness, or lightheadedness. Medical history includes Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis, Endometriosis, Osteoarthritis, Raynaud's Syndrome, Dermatomyositis, Chronic Migraines, Degenerative Disc Disease, Neurologic Thoracic Outlet Syndrome, Spinal Spondylosis, Peripheral Neuropathy, Pericarditis, Occipital Neuralgia, Irritable Bowel Syndrome (IBS), and Polycystic Ovary Syndrome (PCOS). The patient is at risk for cardiomyopathy due to chronic pericarditis brought on by SLE. Current medications include Norco 10mg 4 times daily, Butrans Patch 15mcg once weekly, Baclofen 10mg 3 times daily, Indomethacin 25mg twice daily, Plaquenil 200mg once daily (started three months ago), Gabapentin 400mg, 2 capsules 3 times daily, and Imitrex and Zofran as needed for migraine and nausea. Allergies include SSRI medications, contrast dye, Cymbalta, Tramadol, Kenalog Steroid Injections, Benadryl, and Compazine. Family history includes a grandfather with heart disease and leukemia, a sister with an autoimmune disease, and a grandmother with diabetes. The patient uses tobacco but does not consume alcohol or recreational drugs.

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Arora's Assessment

What might be happening

Based on the symptoms and medical history you've provided, here are some possible explanations for your condition:

Leg Swelling and Chest Pain

  1. Heart Failure: Given your history of chronic pericarditis and SLE, heart failure could be a potential cause of your leg swelling and chest pain. Heart failure can lead to fluid buildup in the legs (edema) and cause chest pain due to reduced blood flow to the heart.

    • Typical Treatments/Testing: Your doctor may recommend blood tests, an echocardiogram, or other imaging studies to assess heart function. Treatment may include medications to reduce fluid buildup, improve heart function, and manage symptoms.
  2. Cardiomyopathy: As you mentioned being at risk for cardiomyopathy due to chronic pericarditis, this condition could also explain your symptoms. Cardiomyopathy can weaken the heart muscle, leading to symptoms like leg swelling, chest pain, and palpitations.

    • Typical Treatments/Testing: Diagnosis may involve imaging studies like an echocardiogram or MRI, and treatment may include medications, lifestyle changes, or in severe cases, surgical interventions.

Severe Fatigue and Knee Pain

  1. Systemic Lupus Erythematosus (SLE): SLE can cause severe fatigue and joint pain, including knee pain. The chronic inflammation associated with SLE can lead to these symptoms.

    • Typical Treatments/Testing: Management of SLE often involves medications like corticosteroids, immunosuppressants, and antimalarials (e.g., Plaquenil). Regular follow-ups with your rheumatologist are essential.
  2. Rheumatoid Arthritis: This condition can also contribute to your knee pain and fatigue. Rheumatoid arthritis causes chronic inflammation of the joints, leading to pain and stiffness.

    • Typical Treatments/Testing: Treatment may include disease-modifying antirheumatic drugs (DMARDs), biologics, and physical therapy.

What you can do

Leg Swelling and Chest Pain

  1. Seek Medical Attention: Given the severity of your symptoms and the potential for serious conditions like heart failure or cardiomyopathy, it's crucial to see a healthcare provider as soon as possible. They may perform tests to assess your heart function and determine the appropriate treatment.
  2. Lifestyle Modifications:
    • Elevate Your Legs: Elevate your legs when sitting or lying down to help reduce swelling.
    • Limit Salt Intake: Reducing salt in your diet can help decrease fluid retention.
    • Monitor Symptoms: Keep track of your symptoms, including the severity and duration of swelling and chest pain, using the MDandMe journal. This information can be valuable for your healthcare provider.

Severe Fatigue and Knee Pain

  1. Consult Your Rheumatologist: Regular follow-ups with your rheumatologist are essential to manage SLE and rheumatoid arthritis effectively. They may adjust your medications or recommend additional treatments.
  2. Pain Management:
    • Medications: Continue taking your prescribed medications, such as Norco, Baclofen, and Gabapentin, as directed by your healthcare provider.
    • Physical Therapy: Consider physical therapy to improve joint function and reduce pain. Your healthcare provider can refer you to a physical therapist.
    • Heat and Cold Therapy: Applying heat or cold packs to your knee may help alleviate pain and reduce inflammation.

What you should look out for

Given the potential seriousness of your symptoms, you should seek medical care as soon as possible. Reasons to seek care even more urgently include:

  • Worsening Chest Pain: If your chest pain becomes more severe, or if you experience new symptoms like shortness of breath, fainting, or severe palpitations, seek emergency medical attention immediately.
  • Increased Swelling: If the swelling in your legs worsens or spreads to other parts of your body, contact your healthcare provider.
  • New or Worsening Symptoms: Any new or worsening symptoms, such as increased fatigue, joint pain, or other concerning signs, should be reported to your healthcare provider promptly.

Remember, while I can provide information and suggestions, it's essential to consult with real healthcare professionals for a formal diagnosis and appropriate treatment. If you have more questions or need further assistance, feel free to continue the conversation.

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5 mo ago

People Also Ask


What could be causing the swelling in my legs?

The swelling in your legs could be due to heart failure or cardiomyopathy, especially given your history of chronic pericarditis and SLE. These conditions can lead to fluid buildup in the legs. It's important to consult with a healthcare provider for proper diagnosis and treatment.


How can I manage the sharp, burning chest pain I am experiencing?

Managing sharp, burning chest pain involves seeking medical attention to rule out serious conditions like heart failure or cardiomyopathy. Your doctor may recommend medications or lifestyle changes to help manage the pain. Keeping track of your symptoms and avoiding activities that exacerbate the pain can also be helpful.


What might be contributing to my severe fatigue and knee pain?

Severe fatigue and knee pain could be related to your SLE or rheumatoid arthritis, both of which cause chronic inflammation and joint pain. Regular follow-ups with your rheumatologist and appropriate medication management are crucial in addressing these symptoms.


Are there lifestyle changes I can make to help with my symptoms?

Lifestyle changes that may help include elevating your legs to reduce swelling, limiting salt intake to decrease fluid retention, and engaging in physical therapy to improve joint function. Monitoring your symptoms and maintaining regular communication with your healthcare provider are also important steps.


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