[35F] With persistent petechiae and fatigue

Patient Description

A 35-year-old female presents with persistent petechiae all over the body, noted since at least August, and chronic fatigue. The patient reports that fatigue may be exacerbated by stress, particularly in social situations. Additional symptoms include swollen lymph nodes, fever, night sweats, and unusual bruising. The patient has a history of a swollen thyroid gland, or goiter, present since age 10, but thyroid function tests have consistently returned normal results. The patient denies any unexplained weight loss but reports significant water retention. No recent blood tests or medical evaluations have been conducted regarding these symptoms. The patient is currently taking a B complex vitamin and a thyroid support supplement, with no other medications or known allergies.

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Arora's Assessment

What might be happening

Based on the symptoms you've described, there are a few potential explanations for what you might be experiencing:

  1. Hematological Disorders: The combination of persistent petechiae, swollen lymph nodes, fatigue, and easy bruising could suggest a blood-related condition. Conditions such as thrombocytopenia (low platelet count) or a more serious hematological disorder like leukemia could be possibilities. These conditions can lead to bleeding under the skin (petechiae), fatigue, and swollen lymph nodes. Blood tests, including a complete blood count (CBC), would be essential to evaluate this further.

  2. Thyroid Dysfunction: Although your blood tests have not shown thyroid problems, the presence of a goiter and your symptoms could still suggest thyroid dysfunction. Sometimes, thyroid issues can present with non-specific symptoms like fatigue and swelling. An ultrasound of the thyroid or further endocrinological evaluation might be necessary.

  3. Autoimmune Conditions: Some autoimmune disorders can cause symptoms like fatigue, swollen lymph nodes, and skin changes. Conditions such as lupus or vasculitis could be considered, and specific blood tests for autoimmune markers might be helpful.

What you can do

Petechiae and Bruising:

  • It's important to see a healthcare provider for a thorough evaluation, as these symptoms could indicate a serious underlying condition. They may recommend blood tests to check your platelet levels and other blood components.
  • Avoid activities that could lead to bruising or injury until you have more information about your condition.

Fatigue:

  • Ensure you are getting adequate rest and managing stress as best as you can. Techniques such as mindfulness or gentle yoga might be beneficial.
  • Keep a journal of your fatigue levels and any activities or foods that seem to impact your energy. This can be done using MDandMe to track your symptoms and share insights with your healthcare provider.

Swollen Lymph Nodes:

  • Monitor the size and tenderness of your lymph nodes. If they continue to enlarge or become painful, seek medical attention promptly.

General Health:

  • Maintain a balanced diet rich in fruits, vegetables, and lean proteins to support your overall health.
  • Stay hydrated and consider gentle exercise, as tolerated, to help with energy levels and overall well-being.

What you should look out for

Given the potential seriousness of your symptoms, it's important to seek medical care for a comprehensive evaluation. You should seek more urgent care if you experience:

  • Significant or rapid enlargement of lymph nodes
  • Severe or unexplained bleeding
  • New or worsening symptoms, such as shortness of breath or chest pain
  • Any signs of infection, such as fever or chills, that do not resolve

Remember, while I can provide information and suggestions, it's crucial to consult with a healthcare professional for a formal diagnosis and appropriate treatment.

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6 mo ago

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People Also Ask


What are petechiae and what causes them?

Petechiae are small, red or purple spots on the skin caused by bleeding under the skin. They can be caused by a variety of conditions, including low platelet counts, infections, or certain medications.


How can stress affect fatigue levels?

Stress can exacerbate fatigue by affecting sleep quality, increasing muscle tension, and causing mental exhaustion. Managing stress through relaxation techniques and adequate rest can help alleviate fatigue.


What are the potential causes of swollen lymph nodes?

Swollen lymph nodes can be caused by infections, autoimmune diseases, or more serious conditions like cancers. They are part of the body's immune response and can indicate that the body is fighting an infection or other issue.


What should I do if I notice unusual bruising?

If you notice unusual bruising, it's important to consult a healthcare provider. They may recommend blood tests to check for underlying conditions such as clotting disorders or platelet abnormalities.


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