[28F] With multiple growing and hardening lumps and extreme fatigue

Patient Description

A 28-year-old female reports a growing and hardening lump in her leg, initially noticed a year ago. The lumps have spread throughout her body and have become very irregular and large. The patient also experiences extreme fatigue and changes in appetite but has not noticed any significant weight loss. There are no changes in the color or temperature of the skin over the lumps. The patient reports frequent hot flashes but no recent fever. She has unexplained bruising but is unsure about swollen lymph nodes. Family history includes a grandmother with cervical cancer and a brother with bone cancer. The patient uses tobacco daily and has no recent travel to areas with known infectious diseases. Her past medical history includes PTSD, manic depression, night terrors, and anxiety, diagnosed in 2019. She is not currently taking any medications and has no known allergies.

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Arora's Assessment

Certainly, Victoria. Based on the information you've provided, here is some advice that might help you understand your condition better:

What might be happening

Based on your symptoms and history, here are some possible explanations:

  • Lipomas or Lipomatosis: These are benign (non-cancerous) tumors made of fat tissue. They can grow and become more numerous over time. They are usually soft, but can become harder if they calcify or if there is a fibrous component.

    • Treatment: Typically, lipomas do not require treatment unless they cause pain or other symptoms. Surgical removal is an option if they are bothersome.
  • Lymphoma: This is a type of cancer that starts in the lymphatic system. Symptoms can include lumps under the skin, fatigue, night sweats, and unexplained bruising.

    • Treatment: Treatment options include chemotherapy, radiation therapy, and targeted therapy. A biopsy is usually required to confirm the diagnosis.
  • Metastatic Cancer: Given your family history of cancer, it's important to consider that these lumps could be metastatic, meaning they have spread from another part of the body.

    • Treatment: Treatment depends on the type and stage of cancer. It often involves a combination of surgery, chemotherapy, and radiation therapy.
  • Fibromatosis: This is a group of conditions characterized by the growth of fibrous tissue. These lumps can be hard and irregular.

    • Treatment: Treatment may include surgery, radiation therapy, or medication to slow the growth of the fibrous tissue.

What you can do

  1. Consult a Healthcare Provider: It's crucial to see a doctor for a formal assessment. They may recommend imaging tests like an ultrasound, CT scan, or MRI, and possibly a biopsy to determine the nature of the lumps.
  2. Track Your Symptoms: Use MDandMe to journal your symptoms, track the growth of the lumps, and note any other changes in your health. This information can be very helpful for your healthcare provider.
  3. Manage Fatigue: Ensure you get adequate rest, maintain a balanced diet, and stay hydrated. Gentle exercise, like walking, can also help improve your energy levels.
  4. Mental Health Support: Given your history of PTSD, manic depression, night terrors, and anxiety, consider seeking support from a mental health professional. Managing stress and mental health can improve your overall well-being.

What you should look out for

Seek medical attention more urgently if you experience:

  • Rapidly increasing size or number of lumps
  • Severe pain or discomfort
  • Unexplained weight loss
  • Persistent night sweats or fever
  • Difficulty breathing or swallowing

Remember, while I can provide information and suggestions, it's essential to consult with a healthcare professional for a formal diagnosis and appropriate treatment. Take care, Victoria.

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4 mo ago


People Also Ask


What are the possible causes of lumps spreading throughout the body?

Possible causes of lumps spreading throughout the body include benign conditions like lipomas or fibromatosis, as well as more serious conditions such as lymphoma or metastatic cancer. A healthcare provider can help determine the cause through imaging tests and possibly a biopsy.


How can extreme fatigue and changes in appetite be related to the lumps?

Extreme fatigue and changes in appetite can be symptoms associated with systemic conditions like lymphoma or other cancers. These symptoms may also be related to the body's response to the growths or underlying metabolic changes.


What role does family history play in the development of cancerous conditions?

Family history can significantly increase the risk of developing certain types of cancer. Genetic predispositions can be inherited, making it important to inform healthcare providers about any family history of cancer for appropriate screening and monitoring.


What are the recommended steps for someone experiencing unexplained bruising and hot flashes?

For unexplained bruising and hot flashes, it is important to consult a healthcare provider. They may conduct blood tests to check for clotting disorders or hormonal imbalances. Keeping a symptom diary can also help in identifying patterns and triggers.


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1 Comments


Angelina#43016

4 mo ago

Of course we experience depression.. the affect it has especially on a woman is diminished quality ofblifebit affects us mentally and emotionally

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