[28F] Experiencing intermittent anisocoria

Patient Description

A 28-year-old female presents with a history of anisocoria, first noticed at the age of 16 and possibly observed during childhood. The patient reports that the right pupil appears larger than the left, especially in dim lighting conditions, and there is slight eyelid drooping on the affected side. These symptoms are not accompanied by severe headaches, neck stiffness, changes in consciousness, or any recent trauma. The patient is currently taking Zoloft but has no known drug allergies or adverse reactions to medications. There is no significant past medical history, including no known neurological disorders in the family that might affect the eyes or pupils.

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Arora's Assessment

What might be happening

Based on the information you've provided, the most likely explanation for your symptoms is:

  • Physiological Anisocoria: This is a benign condition where one pupil is naturally larger than the other. It affects about 20% of the population and is usually harmless. The difference in pupil size is usually less than 1 mm and the pupils react normally to light and dark. It can be more noticeable in dim light.
    • There is no specific treatment for physiological anisocoria as it is a normal variant and does not cause any health problems.

Other possibilities include:

  • Horner's Syndrome: This is a rare condition that can cause the pupil to be smaller on one side, along with a droopy eyelid. However, the smaller pupil in Horner's syndrome usually becomes more noticeable in bright light, which is the opposite of what you're experiencing.

    • Treatment for Horner's syndrome depends on identifying and managing the underlying cause.
  • Adie's Pupil: This is a condition where one or both pupils are large and react slowly to light. However, this condition usually presents with other symptoms, such as loss of deep tendon reflexes.

    • Treatment for Adie's Pupil is usually not necessary unless the symptoms are bothersome. In some cases, eye drops may be prescribed to constrict the pupil.
  • Medication side effects: Certain medications, such as those used to treat conditions like anxiety, can cause changes in pupil size. However, Zoloft (sertraline) is not commonly associated with anisocoria.

    • If a medication is causing anisocoria, the prescribing doctor may adjust the dosage or switch to a different medication.

What you can do

Given that you've had this condition since you were a teenager and you're not experiencing any other symptoms, it's likely that your anisocoria is physiological and not a cause for concern. However, it would be a good idea to have an eye exam to confirm this. If you haven't had an eye exam recently, consider scheduling one. The eye doctor can measure your pupils in different lighting conditions and determine whether your anisocoria is something that needs further investigation.

What you should look out for

While your anisocoria is likely harmless, there are some signs that you should seek immediate medical attention:

  • Sudden changes in pupil size
  • New or worsening drooping of the eyelid
  • Changes in vision, such as blurred or double vision
  • Pain, redness, or swelling in or around the eyes
  • Severe headache, neck stiffness, or changes in consciousness

Remember, I'm an AI and not a doctor. You should seek care from a real health professional to receive a formal diagnosis and treatment if appropriate.

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People Also Ask


What is physiological anisocoria and is it harmful?

Physiological anisocoria is a benign condition where one pupil is naturally larger than the other. It affects about 20% of the population and is usually harmless, with no specific treatment required.


How can I differentiate between physiological anisocoria and Horner's syndrome?

Physiological anisocoria typically presents with a slight difference in pupil size that is more noticeable in dim light, whereas Horner's syndrome usually causes the affected pupil to be smaller and more noticeable in bright light, along with a droopy eyelid.


Can medications like Zoloft cause changes in pupil size?

Zoloft (sertraline) is not commonly associated with anisocoria. However, some medications can cause changes in pupil size. If you suspect a medication is causing anisocoria, consult your doctor for advice.


What symptoms should prompt me to seek immediate medical attention for anisocoria?

Seek immediate medical attention if you experience sudden changes in pupil size, new or worsening drooping of the eyelid, changes in vision, severe headache, neck stiffness, or changes in consciousness.


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