[25F] Experiencing worsening memory loss over several years

Patient Description

A 25-year-old female has been experiencing worsening memory loss over several years, affecting approximately 85% of her daily life. The memory loss is exacerbated by lack of sleep, stress, anxiety, and heat. The patient sometimes forgets significant events, such as her own birthday, and daily activities, like what she ate the previous day. In addition to memory loss, she has difficulty concentrating, episodes of confusion, issues with coordination or balance, and switches words backwards in her head. There are no changes in mood, behavior, vision, or sense of smell or taste. The patient has a family history of dementia and Parkinson's disease and has used substances like alcohol (sober for 1 year), marijuana (for ADHD, nausea, and insomnia), and nicotine. She has not noticed any improvement in her memory since stopping alcohol and has not experienced any adverse effects from marijuana use. Chronic medical conditions include right ventricular hypertrophy, severe clinical depression, severe anxiety with depression, CPTSD, chronic bilateral low back pain without sciatica, ADHD, back pain, tremor, and muscle twitches. Allergies include adhesives and unknown body/skin products. Current medications are Escilatopram, Famotidine, and Promethazine.

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Arora's Assessment

What might be happening

Based on the information you've provided, here are some possible explanations for your symptoms:

Memory Loss and Cognitive Issues

  1. Chronic Stress and Anxiety: Given your history of severe clinical depression, severe anxiety with depression, and CPTSD, chronic stress and anxiety can significantly impact memory and cognitive function. Stress hormones like cortisol can affect the brain areas involved in memory.
  2. Neurological Conditions: The family history of dementia and Parkinson's disease raises the possibility of a neurological condition. While you haven't been diagnosed with these, they can sometimes present with memory loss and cognitive issues.
  3. Medication Side Effects: Some medications, including those for depression and anxiety, can have side effects that impact memory and cognitive function.

Muscle Twitches and Tremors

  1. Essential Tremor or Familial Tremor: Given the family history of Parkinson's disease and your symptoms of tremors and muscle twitches, essential tremor or a related condition could be a possibility.
  2. Neurological Disorders: Conditions like Parkinson's disease or other movement disorders could explain the tremors and muscle twitches, especially given the family history.

Coordination and Balance Issues

  1. Neurological Conditions: Coordination and balance issues can be related to neurological conditions, which could also be linked to your tremors and memory issues.
  2. Medication Side Effects: Some medications can affect coordination and balance.

What you can do

Memory Loss and Cognitive Issues

  • Consult a Neurologist: Given the severity and duration of your symptoms, it would be beneficial to consult a neurologist for a comprehensive evaluation. They may recommend cognitive tests, brain imaging, or other diagnostic procedures.
  • Manage Stress and Anxiety: Techniques such as mindfulness, meditation, and cognitive-behavioral therapy (CBT) can help manage stress and anxiety, potentially improving memory and cognitive function.
  • Healthy Lifestyle: Ensure you get adequate sleep, maintain a balanced diet, and engage in regular physical activity. These can all support cognitive health.
  • Use MDandMe: Journal your symptoms, track your progress, and share your notes with your healthcare provider for better management.

Muscle Twitches and Tremors

  • Consult a Neurologist: A neurologist can help diagnose the cause of your tremors and muscle twitches. They may recommend tests like electromyography (EMG) or nerve conduction studies.
  • Medication Review: Discuss your current medications with your healthcare provider to see if any could be contributing to your symptoms.
  • Lifestyle Adjustments: Avoid triggers like stress, heat, and lack of sleep. Practice relaxation techniques and ensure you stay hydrated.

Coordination and Balance Issues

  • Physical Therapy: A physical therapist can help you with exercises to improve coordination and balance.
  • Safety Measures: Take precautions to prevent falls, such as using handrails and avoiding slippery surfaces.

What you should look out for

Given the complexity and potential seriousness of your symptoms, you should seek medical care as soon as possible. Reasons to seek care even more urgently include:

  • Sudden Worsening of Symptoms: If you experience a sudden worsening of memory loss, tremors, or balance issues.
  • New Symptoms: If you develop new symptoms like severe headaches, vision changes, or difficulty speaking.
  • Safety Concerns: If your coordination and balance issues lead to falls or other safety concerns.

Remember, while I can provide guidance, it's essential to consult with healthcare professionals for a formal diagnosis and treatment plan. If you have more questions or need further assistance, feel free to continue our conversation.

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4 mo ago


People Also Ask


Can stress and anxiety really cause memory loss and cognitive issues?

Yes, chronic stress and anxiety can lead to memory loss and cognitive issues. Stress hormones like cortisol can negatively impact brain areas involved in memory and cognition.


What are the potential side effects of medications like Escilatopram on memory and cognition?

Escilatopram, an antidepressant, can have side effects that include memory issues, confusion, and difficulty concentrating. It's important to discuss any side effects with your healthcare provider.


How can family history of neurological conditions like dementia and Parkinson's disease affect my health?

A family history of neurological conditions can increase your risk of developing similar issues. It's important to monitor symptoms and consult with a healthcare provider for early detection and management.


What lifestyle changes can help improve memory and cognitive function?

Lifestyle changes such as getting adequate sleep, maintaining a balanced diet, engaging in regular physical activity, and practicing stress management techniques like mindfulness and meditation can support cognitive health.


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