[24F] With chronic joint pain and fatigue

Patient Description

A 24-year-old female presents with chronic joint pain in the shoulder and elbow lasting for about a year and a half. The pain is described as achy and dull, rated 5-6 on a scale of 1-10, and worsens at night. Over-the-counter pain relief and opioids have not been effective. The patient also reports constant fatigue, some morning stiffness, and similar pain in the neck and back. She has experienced weight loss of approximately 40 lbs over the past three months and has had mouth sores. There is a family history of rheumatoid arthritis in her mother and grandmother. Her past medical history includes a serious MRSA infection in 2006 and diagnoses of bipolar disorder and PTSD in 2014. The patient is not currently taking any medications and has no known drug allergies.

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Arora's Assessment

What might be happening

Based on the information you've provided, here are some possible explanations for your symptoms:

Joint Pain and Fatigue

  1. Rheumatoid Arthritis (RA):

    • Rationale: Given your family history of rheumatoid arthritis and the nature of your symptoms (chronic joint pain, warmth in the joints, and morning stiffness), RA is a strong possibility. RA is an autoimmune disorder that causes chronic inflammation of the joints.
    • Typical Treatments: Treatment often includes medications like disease-modifying antirheumatic drugs (DMARDs), biologics, and nonsteroidal anti-inflammatory drugs (NSAIDs). Physical therapy and lifestyle changes can also help manage symptoms.
    • Testing: Blood tests (like rheumatoid factor and anti-CCP antibodies) and imaging studies (X-rays, MRIs) are commonly used to diagnose RA.
  2. Fibromyalgia:

    • Rationale: Chronic widespread pain and fatigue are hallmark symptoms of fibromyalgia. This condition often coexists with other conditions like PTSD and bipolar disorder.
    • Typical Treatments: Treatment may include medications like antidepressants, anticonvulsants, and pain relievers. Exercise, stress management, and cognitive behavioral therapy (CBT) can also be beneficial.
    • Testing: Diagnosis is usually clinical, based on symptoms and physical examination.

Weight Loss and Mouth Sores

  1. Systemic Lupus Erythematosus (SLE):
    • Rationale: Unexplained weight loss, mouth sores, and joint pain could be indicative of SLE, another autoimmune disorder.
    • Typical Treatments: Treatment often includes corticosteroids, immunosuppressive drugs, and antimalarials like hydroxychloroquine.
    • Testing: Blood tests (like ANA, anti-dsDNA) and urine tests are commonly used for diagnosis.

What you can do

Joint Pain and Fatigue

  • See a Rheumatologist: Given the chronic nature and severity of your symptoms, it's important to consult a rheumatologist for a thorough evaluation and diagnosis.
  • Pain Management: While waiting for your appointment, you can:
    • Apply heat or cold packs to the affected joints.
    • Engage in gentle exercises like stretching or yoga to maintain joint flexibility.
    • Use over-the-counter NSAIDs like ibuprofen (Advil) for temporary relief, but avoid overuse.
  • Symptom Tracking: Use MDandMe to journal your symptoms, track your progress, and share your medical notes with your healthcare provider.

Weight Loss and Mouth Sores

  • Consult a Primary Care Physician: Rapid weight loss and mouth sores are concerning and should be evaluated by a healthcare provider.
  • Nutritional Support: Ensure you are eating a balanced diet rich in nutrients to support your overall health.
  • Symptom Tracking: Document any additional symptoms or changes in your condition using MDandMe.

What you should look out for

Given the complexity and severity of your symptoms, you should seek medical care as soon as possible. Reasons to seek care even more urgently include:

  • Severe Joint Pain: If the pain becomes unbearable or significantly limits your daily activities.
  • New Symptoms: Such as fever, unexplained rashes, or significant changes in your health.
  • Mental Health: Given your history of bipolar disorder and PTSD, any worsening of mental health symptoms should prompt immediate consultation with a mental health professional.

Remember, while I can provide information and suggestions, it's crucial to consult with real healthcare professionals for a formal diagnosis and appropriate treatment.

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5 mo ago

People Also Ask


What are the common symptoms of rheumatoid arthritis?

Common symptoms of rheumatoid arthritis include joint pain, swelling, and stiffness, particularly in the morning or after periods of inactivity. Other symptoms can include fatigue, fever, and loss of appetite.


How is fibromyalgia diagnosed and treated?

Fibromyalgia is typically diagnosed based on a history of widespread pain lasting more than three months, along with other symptoms like fatigue and sleep disturbances. Treatment often includes medications such as antidepressants and anticonvulsants, as well as lifestyle changes like exercise and stress management.


What could cause unexplained weight loss and mouth sores?

Unexplained weight loss and mouth sores can be symptoms of systemic lupus erythematosus (SLE), an autoimmune disorder. Other potential causes include nutritional deficiencies, infections, or other autoimmune conditions.


What lifestyle changes can help manage chronic joint pain?

Lifestyle changes that can help manage chronic joint pain include regular low-impact exercise, maintaining a healthy weight, using heat or cold therapy, practicing stress-reduction techniques, and ensuring a balanced diet rich in anti-inflammatory foods.


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