[23F] With sharp abdominal pain, nausea, and significant weight loss

Patient Description

A 23-year-old female presents with sharp abdominal pain that has persisted for several weeks, rated as 8 out of 10 in severity. The pain is constant, lasting for hours, and is somewhat alleviated by heat and hot baths. The patient reports feeling bloated on the right side of the abdomen for a couple of hours. Accompanying symptoms include nausea without vomiting and a loss of appetite. The patient has experienced an unintentional weight loss of 50 pounds over the past year. Menstrual periods are irregular, and the patient has a Nexplanon implant, which has been associated with side effects such as depression, weight changes, and crampy clots in the urine. The patient's medical history includes chronic UTIs and nephritis since the age of 8. Current medications include Cymbalta 60 mg, Trazodone 50 mg, and Buspar 30 mg twice daily. The patient also uses marijuana. There are no known drug allergies.

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Arora's Assessment

What might be happening

Based on the symptoms you've described, there are a few potential explanations for what might be happening:

  1. Gastrointestinal Issues: The combination of sharp abdominal pain, bloating, nausea, and significant weight loss could suggest a gastrointestinal condition such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), or even a peptic ulcer. These conditions can cause chronic abdominal pain and changes in appetite and weight.

  2. Gallbladder or Liver Issues: Given the location of your bloating and pain on the right side, gallbladder issues such as gallstones or liver conditions could be considered. These can cause pain, bloating, and nausea.

  3. Kidney Issues: With your history of nephritis and chronic UTIs, kidney-related issues could also be contributing to your symptoms, especially if there is any involvement of the urinary tract.

  4. Medication Side Effects: Some of your medications, like Cymbalta and Trazodone, can cause gastrointestinal side effects, including nausea and changes in appetite.

It's important to consult with a healthcare professional to get a proper diagnosis. They may recommend tests such as blood work, imaging studies, or endoscopy to determine the cause of your symptoms.

What you can do

Abdominal Pain and Bloating:

  • Keep a food diary to track any foods that may trigger or worsen your symptoms.
  • Eat smaller, more frequent meals to help manage bloating and nausea.
  • Stay hydrated, but avoid carbonated beverages that can increase bloating.
  • Use the MDandMe app to journal your symptoms and track any patterns or changes over time.

Weight Loss and Appetite Changes:

  • Try to eat nutrient-dense foods that are easy on your stomach, such as bananas, rice, applesauce, and toast (the BRAT diet).
  • Consider nutritional supplements or shakes if you're struggling to maintain your weight.
  • Discuss your weight loss with a healthcare provider to rule out any serious underlying conditions.

Back Pain:

  • Apply heat to the affected area to help relieve pain and tension.
  • Practice gentle stretching exercises to improve flexibility and reduce discomfort.
  • Consider using a cushion or pillow when sitting to provide support and reduce strain on your back.

What you should look out for

While your symptoms are concerning, they may not be immediately life-threatening. However, you should seek medical attention if you experience any of the following:

  • Severe or worsening abdominal pain
  • Blood in your stool or urine
  • Persistent vomiting or inability to keep food down
  • Signs of dehydration, such as dizziness or decreased urination
  • Fever or chills

Remember, it's important to consult with a healthcare professional to receive a formal diagnosis and appropriate treatment. If you have any more questions or need further assistance, feel free to reach out.

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People Also Ask


What could be causing sharp abdominal pain and bloating on the right side?

Sharp abdominal pain and bloating on the right side could be caused by gastrointestinal issues such as IBS or IBD, gallbladder problems like gallstones, or liver conditions. It's important to consult a healthcare professional for a proper diagnosis.


Can medications like Cymbalta and Trazodone cause gastrointestinal side effects?

Yes, medications like Cymbalta and Trazodone can cause gastrointestinal side effects, including nausea and changes in appetite. If you suspect your medication is affecting you, discuss it with your doctor.


How can I manage unintentional weight loss and loss of appetite?

To manage unintentional weight loss and loss of appetite, try eating smaller, more frequent meals with nutrient-dense foods. Consider nutritional supplements or shakes and consult a healthcare provider to rule out serious conditions.


What symptoms should prompt me to seek immediate medical attention?

Seek immediate medical attention if you experience severe or worsening abdominal pain, blood in your stool or urine, persistent vomiting, signs of dehydration, or fever and chills.


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