[21F] Experiencing skin discoloration and coldness

Patient Description

A 21-year-old female reports a red-purple discoloration on her hands, stomach, thighs, feet, and arms that has been occurring for a few months. The discoloration worsens with cold exposure and the affected areas feel cold to the touch. The skin returns to normal when warmed up, with no accompanying numbness, tingling, or pain. The patient has been using AndroGel (20.25mg daily) for 2 years, with hair growth and voice deepening as side effects. She has an allergy to penicillin and amoxicillin but no other known pre-existing conditions or chronic illnesses.

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Arora's Assessment

What might be happening

Based on your symptoms, a possible diagnosis could be:

  • Raynaud's Phenomenon: This condition causes some areas of your body — such as your fingers and toes — to feel numb and cold in response to cold temperatures or stress. It can also affect other areas such as your nose, lips, ears and even nipples. The skin discoloration is usually a sequence of white (pale), then blue (cyanosis), then red (reperfusion) during an episode, but not all individuals experience all three colors. The skin may also feel cold and numb during an episode.
    • Treatment for Raynaud's Phenomenon typically involves avoiding triggers such as cold temperatures and stress. Medications can be prescribed by a doctor to help manage symptoms in more severe cases.

Please note that while AndroGel (testosterone) can have various effects on the body, it is not typically associated with causing skin discoloration or coldness.

What you can do

  1. Keep your body warm, especially in cold weather. Wear gloves and warm socks, use a blanket, and drink warm liquids.
  2. Try to avoid sudden changes in temperature.
  3. Avoid stress and practice stress-relieving activities like yoga, meditation, or deep-breathing exercises.
  4. Quit smoking if you smoke, as nicotine can constrict your blood vessels and worsen symptoms.
  5. Exercise regularly to improve your circulation.

What you should look out for

If your symptoms worsen, or if you start to experience other symptoms such as:

  • Pain, tingling, or numbness in the affected areas
  • Sores or ulcers on your fingers or toes
  • A sequence of color changes from white to blue to red in the affected areas

You should seek medical attention promptly.

Remember, this advice is meant to be general in nature, and specific causes may not apply to your situation. Always consult with a healthcare provider for appropriate examination, testing, and care recommendations.

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10 mo ago

People Also Ask


What is Raynaud's Phenomenon and how does it affect the body?

Raynaud's Phenomenon is a condition where some areas of the body, such as fingers and toes, feel numb and cold in response to cold temperatures or stress. It can cause a sequence of color changes in the skin, typically white, blue, and then red, and may also affect other areas like the nose, lips, and ears.


Can AndroGel cause skin discoloration or coldness?

AndroGel, which is a form of testosterone, is not typically associated with causing skin discoloration or coldness. Its common side effects include hair growth and voice deepening, but not the symptoms described.


What lifestyle changes can help manage Raynaud's Phenomenon symptoms?

To manage Raynaud's Phenomenon, it's important to keep warm, avoid sudden temperature changes, reduce stress, quit smoking, and exercise regularly to improve circulation.


When should someone with Raynaud's Phenomenon seek medical attention?

Medical attention should be sought if symptoms worsen, such as experiencing pain, tingling, or numbness, developing sores or ulcers on fingers or toes, or if the color changes in the skin follow a sequence from white to blue to red.


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