[19F] With persistent neck lumps and systemic symptoms

Patient Description

A 19-year-old female has been experiencing small, hard, fixed lumps in her neck for several months. The lumps fluctuate in size but do not move. The patient reports associated symptoms including night sweats, unexplained weight loss, significant fatigue, occasional shortness of breath, and sometimes a persistent cough. There is no recent history of fever, neck injury, or family history of cancer, particularly lymphoma or leukemia. The patient does not use tobacco, alcohol, or recreational drugs. No other pre-existing conditions or chronic illnesses were mentioned.

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Arora's Assessment

What might be happening

Based on the symptoms you've described, here are some possible explanations:

Lumps in Neck

  • Lymphadenopathy: This is a condition where the lymph nodes become enlarged. It can be caused by infections, autoimmune diseases, or cancers like lymphoma. Given that your lumps are fixed and have been present for months, it is important to rule out more serious causes.
  • Lymphoma: This is a type of cancer that affects the lymphatic system. Symptoms can include enlarged lymph nodes, night sweats, unexplained weight loss, and fatigue. The fact that your lumps change in size, are fixed, and you have night sweats and weight loss makes this a possibility that needs to be evaluated by a healthcare professional.

Night Sweats, Weight Loss, and Fatigue

  • Infections: Chronic infections like tuberculosis or mononucleosis can cause night sweats, weight loss, and fatigue.
  • Thyroid Issues: Hyperthyroidism can cause weight loss, fatigue, and sometimes night sweats.
  • Cancer: As mentioned, lymphoma or other cancers can present with these symptoms.

Shortness of Breath and Cough

  • Respiratory Infections: Chronic or recurrent respiratory infections can cause these symptoms.
  • Asthma or Allergies: These can also cause intermittent shortness of breath and cough.

What you can do

Lumps in Neck

  • See a Doctor: Given the persistence and characteristics of your lumps, it is crucial to see a healthcare provider as soon as possible. They may perform a physical examination, blood tests, and imaging studies like an ultrasound or CT scan. A biopsy may also be necessary to rule out cancer.
  • Monitor Symptoms: Keep track of any changes in the size or number of lumps, and any new symptoms that arise. You can use MDandMe to journal your symptoms and track progress.

Night Sweats, Weight Loss, and Fatigue

  • Medical Evaluation: These symptoms are concerning and should be evaluated by a healthcare provider. Blood tests, imaging studies, and possibly a referral to a specialist may be needed.
  • Self-Care: Ensure you are getting adequate rest, staying hydrated, and eating a balanced diet. Avoiding stress and practicing relaxation techniques can also help manage fatigue.

Shortness of Breath and Cough

  • Consult a Doctor: These symptoms should be evaluated, especially if they are persistent or worsening. Your doctor may recommend lung function tests or imaging studies.
  • Avoid Triggers: If you have known triggers for your cough or shortness of breath, such as allergens or irritants, try to avoid them.

What you should look out for

Given the severity of your symptoms and the possibility of serious underlying conditions, you should seek medical care as soon as possible. Reasons to seek care even more urgently include:

  • Rapidly Growing Lumps: If the lumps in your neck grow rapidly or become more painful.
  • Severe Shortness of Breath: If you experience severe difficulty breathing or chest pain.
  • New Symptoms: If you develop new symptoms like fever, severe fatigue, or unexplained bruising.

Remember, while I can provide information and suggestions, I am not a substitute for a healthcare professional. Please consult a doctor for a formal diagnosis and appropriate treatment.

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5 mo ago


People Also Ask


What could cause small, hard, fixed lumps in the neck that fluctuate in size?

Small, hard, fixed lumps in the neck that fluctuate in size could be due to lymphadenopathy, which is the enlargement of lymph nodes. This can be caused by infections, autoimmune diseases, or cancers such as lymphoma. It's important to have these lumps evaluated by a healthcare professional to rule out serious conditions.


Are night sweats, unexplained weight loss, and fatigue common symptoms of lymphoma?

Yes, night sweats, unexplained weight loss, and fatigue are common symptoms of lymphoma, a type of cancer that affects the lymphatic system. These symptoms, along with enlarged lymph nodes, should be evaluated by a healthcare provider to determine the underlying cause.


What are some possible causes of shortness of breath and a persistent cough?

Shortness of breath and a persistent cough can be caused by respiratory infections, asthma, allergies, or more serious conditions like chronic infections or cancer. It's important to consult a doctor to determine the cause, especially if these symptoms are persistent or worsening.


When should I see a doctor about lumps in my neck and associated symptoms?

You should see a doctor about lumps in your neck and associated symptoms if the lumps are persistent, fixed, or growing, and if you experience symptoms like night sweats, unexplained weight loss, or significant fatigue. These could indicate a serious underlying condition that requires medical evaluation.


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