[19F] With uncontrollable weight gain, fatigue, and cognitive issues

What might be happening

Based on the symptoms you've described, here are some possible explanations:

Hypothyroidism

• Rationale: Hypothyroidism, or an underactive thyroid, can cause symptoms like weight gain, fatigue, brain fog, poor memory, cold intolerance, and constipation. Given your family history of autoimmune diseases, this is a plausible diagnosis.
• Typical Treatments/Testing: Blood tests to measure levels of thyroid-stimulating hormone (TSH) and thyroxine (T4) are commonly used to diagnose hypothyroidism. Treatment usually involves thyroid hormone replacement therapy.

Chronic Fatigue Syndrome (CFS)

• Rationale: CFS is characterized by severe, persistent fatigue that doesn't improve with rest and worsens with physical or mental activity. Brain fog and memory issues are also common symptoms.
• Typical Treatments/Testing: There is no specific test for CFS; it is usually diagnosed based on symptoms and by ruling out other conditions. Treatment focuses on symptom management, including medications, lifestyle changes, and cognitive behavioral therapy.

Depression and Anxiety

• Rationale: Both depression and anxiety can contribute to fatigue, brain fog, and memory issues. The medications you're taking (Wellbutrin and fluoxetine) are commonly prescribed for these conditions, but they may not be fully addressing your symptoms.
• Typical Treatments/Testing: A mental health evaluation can help determine if your symptoms are related to depression or anxiety. Adjustments to your medication or additional therapies may be recommended.

What you can do

Fatigue and Weight Gain

• See a Doctor: Given the severity and persistence of your symptoms, it's important to consult a healthcare provider for a thorough evaluation. Mention your concerns about thyroid issues and request specific tests if they haven't been done recently.
• Lifestyle Changes: Try to maintain a balanced diet and regular exercise routine, even if it's challenging. Small, consistent changes can make a difference over time.
• Medication Review: Discuss your current medications with your doctor to see if any adjustments are needed.

Brain Fog and Poor Memory

• Cognitive Exercises: Engage in activities that stimulate your brain, such as puzzles, reading, or learning a new skill.
• Sleep Hygiene: Ensure you have a regular sleep schedule and a restful sleep environment. Poor sleep can exacerbate brain fog and memory issues.
• Mindfulness and Relaxation: Practices like meditation and deep breathing can help reduce stress and improve cognitive function.

Cold Intolerance and Skin Issues

• Layer Up: Dress in layers to stay warm and comfortable.
• Skin Care: Use gentle, moisturizing skin care products to protect your delicate skin. Avoid harsh soaps and hot showers.

Constipation

• Dietary Changes: Increase your intake of fiber-rich foods like fruits, vegetables, and whole grains. Drink plenty of water.
• Physical Activity: Regular exercise can help stimulate bowel movements.

What you should look out for

Given the complexity of your symptoms, it's important to seek medical care to rule out any serious underlying conditions. Reasons to seek care more urgently include:

• Severe or Sudden Worsening of Symptoms: If your fatigue, weight gain, or other symptoms suddenly worsen, seek medical attention.
• New Symptoms: If you develop new symptoms like shortness of breath, chest pain, or severe abdominal pain, seek immediate medical care.
• Mental Health Concerns: If you experience worsening depression, anxiety, or thoughts of self-harm, seek help from a mental health professional immediately.

Remember, while I can provide information and suggestions, I am not a doctor. It's important to consult with a healthcare professional for a formal diagnosis and treatment plan. You can also use MDandMe to journal your symptoms, track progress, get insights, and share longitudinal medical notes with your provider.