[18F] With recurrent leg pain possibly linked to stress

Patient Description

An 18-year-old female reports experiencing recurrent leg pain since childhood, characterized by a dull ache that predominantly affects one leg at a time but can alternate between legs. The pain typically occurs at night but can start earlier in the day, as early as noon, and persists until she falls asleep. Episodes occur approximately 2-3 times a week and seem to be exacerbated by stress, such as during school assignments. The pain occasionally extends to the knees and calves, but there is no associated swelling, numbness, or tingling. The patient has tried gabapentin 300mg intermittently without noticeable relief. She has a history of grade 2 spondylolisthesis, diagnosed with Spina Bifida Occulta at age 9, PCOS at age 14, and ADHD at age 15. Previous conditions include Osgood-Schlatter disease and suspected plantar fasciitis. Current medications include Vyvanse 70mg daily, Metformin 500mg twice daily, and Tylenol 1000mg 1-3 times daily as needed. The patient is allergic to amoxicillin. There is no known family history of similar symptoms.

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Arora's Assessment

What might be happening

Based on the information you've provided, here are some possible explanations for your leg pain:

  • Growing Pains: Although typically seen in younger children, growing pains can persist into adolescence. They often cause an aching or throbbing sensation in the legs, usually at night, and are not associated with any physical changes or injuries.

    • Treatment generally involves reassurance, as growing pains are not harmful. Over-the-counter pain relief like Tylenol can help manage discomfort.
  • Restless Leg Syndrome (RLS): This condition causes an uncontrollable urge to move the legs, often accompanied by uncomfortable sensations. Stress can exacerbate symptoms, and it typically occurs in the evening or at night.

    • Treatment may include lifestyle changes, such as reducing caffeine and managing stress, as well as medications in some cases.
  • Muscle Fatigue or Overuse: Stress and physical activity can lead to muscle fatigue, which might explain the dull ache you experience. This is more likely if you have been particularly active or stressed.

    • Treatment involves rest, hydration, and gentle stretching exercises.
  • Spondylolisthesis: Although you mentioned that your spondylolisthesis hasn't progressed, it can sometimes cause referred pain in the legs. However, since your pain has been present since childhood, this may not be the primary cause.

    • Treatment typically involves physical therapy, pain management, and in some cases, surgical intervention.

What you can do

While it's important to consult with a healthcare professional for a formal diagnosis, here are some steps you can take to manage your symptoms:

  1. Keep a Symptom Journal: Use MDandMe to track your leg pain episodes, noting the time of day, duration, and any potential triggers. This information can be valuable for your healthcare provider.
  2. Manage Stress: Since stress seems to trigger your pain, consider stress-reduction techniques such as deep breathing exercises, meditation, or yoga.
  3. Stay Active: Engage in regular, moderate exercise to keep your muscles strong and flexible. However, avoid overexertion, which can worsen symptoms.
  4. Apply Heat or Cold: Use a heating pad or ice pack on your legs to help alleviate discomfort.
  5. Ensure Adequate Nutrition: A balanced diet rich in vitamins and minerals can support overall health and potentially reduce symptoms.

What you should look out for

Seek medical attention if you experience any of the following:

  • Severe or worsening pain that doesn't respond to over-the-counter medications
  • New symptoms such as swelling, redness, or warmth in the legs
  • Any signs of nerve involvement, such as numbness or tingling

Remember, while I can provide information and suggestions, it's important to consult with a healthcare professional for a comprehensive evaluation and personalized treatment plan.

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People Also Ask


What are growing pains and can they occur in teenagers?

Growing pains are a common cause of leg pain in children and adolescents, characterized by an aching or throbbing sensation, usually at night. They are not harmful and can persist into the teenage years. Over-the-counter pain relief like Tylenol can help manage discomfort.


What is Restless Leg Syndrome and how can it be managed?

Restless Leg Syndrome (RLS) is a condition that causes an uncontrollable urge to move the legs, often accompanied by uncomfortable sensations. It typically occurs in the evening or at night and can be exacerbated by stress. Management includes lifestyle changes such as reducing caffeine, managing stress, and sometimes medications.


Can stress cause leg pain and what are some ways to manage it?

Yes, stress can contribute to muscle tension and fatigue, leading to leg pain. Managing stress through techniques like deep breathing exercises, meditation, or yoga can help alleviate symptoms.


What is spondylolisthesis and how might it relate to leg pain?

Spondylolisthesis is a condition where one of the vertebrae slips out of place onto the bone below it, which can sometimes cause referred pain in the legs. Treatment typically involves physical therapy, pain management, and in some cases, surgical intervention.


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