[58F] Experiencing significant unexplained weight loss and associated symptoms

Patient Description

A 58-year-old female presents with a weight loss of more than 15%, dropping from 108 lbs to a fluctuating range of 90-95 lbs. The patient reports this weight loss has been occurring over the past year, with an exacerbation of associated symptoms such as severe fatigue, loss of appetite, and intense night sweats in the last three months. The patient also mentions a worsening of nausea during this period. There is no indication of intentional weight loss, and the patient expresses concern about the inability to maintain weight.

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Arora's Assessment

What might be happening

Based on the information you've provided, here are some possible explanations for your symptoms:

  • Cancer: Unexplained weight loss, fatigue, loss of appetite, and night sweats are common symptoms of many types of cancer. This is not to say you have cancer, but these symptoms warrant further investigation.

    • Diagnostic tests for cancer can include blood tests, imaging tests, and biopsies. Treatment depends on the type and stage of cancer, but can include surgery, radiation, and chemotherapy.
  • Hyperthyroidism: This is a condition where your thyroid gland produces too much thyroid hormone. Symptoms can include weight loss, increased appetite, fatigue, and sweating.

    • Diagnosis is usually by blood tests to check your thyroid hormone levels. Treatment can include medication, radioactive iodine, or surgery.
  • Chronic infections or conditions: Certain infections like tuberculosis, or chronic conditions like liver disease or kidney disease, can cause weight loss, fatigue, and night sweats.

    • Diagnosis usually involves blood tests, imaging tests, and sometimes biopsies. Treatment depends on the specific condition.
  • Depression: While we often think of depression as a mental health disorder, it can also have physical symptoms like weight loss, fatigue, and loss of appetite.

    • Diagnosis is usually by a mental health professional. Treatment can include medication, therapy, and lifestyle changes.

What you can do

Given your symptoms, it's important to see a healthcare provider as soon as possible. They can perform the necessary tests to determine the cause of your symptoms and recommend appropriate treatment. In the meantime, try to eat small, frequent meals throughout the day to help maintain your weight. Drink plenty of fluids to stay hydrated, and try to get as much rest as possible.

What you should look out for

If you experience any of the following symptoms, seek medical attention immediately:

  • Severe abdominal pain
  • Difficulty breathing or shortness of breath
  • High fever (over 100.4°F)
  • Confusion or difficulty staying awake
  • Any other symptom that is severe or concerning to you

Remember, while I strive to provide accurate information, I'm not a doctor and this advice should not replace a consultation with a healthcare provider.

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11 mo ago

People Also Ask


What are the common causes of unintentional weight loss in adults?

Unintentional weight loss in adults can be caused by a variety of factors including chronic illnesses like cancer, hyperthyroidism, infections, gastrointestinal disorders, and mental health conditions such as depression. It is important to consult a healthcare provider to determine the underlying cause.


How can hyperthyroidism lead to symptoms like weight loss and fatigue?

Hyperthyroidism occurs when the thyroid gland produces excessive thyroid hormones, which can increase metabolism and lead to symptoms such as weight loss, fatigue, increased appetite, and sweating. Diagnosis is typically confirmed through blood tests measuring thyroid hormone levels.


What are the potential signs of cancer that should prompt further investigation?

Potential signs of cancer that warrant further investigation include unexplained weight loss, persistent fatigue, loss of appetite, night sweats, and other symptoms specific to the type of cancer. Diagnostic tests such as blood tests, imaging, and biopsies are used to confirm the presence of cancer.


How can depression manifest with physical symptoms such as weight loss and fatigue?

Depression can manifest with physical symptoms due to changes in brain chemistry and hormone levels, leading to issues like weight loss, fatigue, and loss of appetite. It is important to seek evaluation from a mental health professional for proper diagnosis and treatment.


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