[46F] With watery diarrhea and right rib pain

Question

Recent labs also showed low B12 and low folate

Patient Description

A 46-year-old female presents with watery and loose diarrhea for the past 4-6 weeks, occurring 2-4 times a day, especially after eating. Each episode lasts about 2-5 minutes. The patient reports no blood or mucus in the stool and has not taken any antibiotics or new medications recently. She also reports pain under the right ribs for the past 2 weeks, similar to previous cholelithiasis pain, rated 6-7 out of 10 in intensity. There have been no abdominal injuries, fever, jaundice, nausea, vomiting, changes in stool color, or weight loss. Recent lab results show a high A1c (7.6) and a low GFR (42). The patient has no history of diabetes or prediabetes and has not been exposed to anyone with similar symptoms or known infections. She recently started taking B12 supplements and has an IUD, resulting in no regular periods. She does not use tobacco, alcohol, or recreational drugs. Her past medical history includes Hashimoto's disease (diagnosed at age 30) and laryngopharyngeal reflux (LPR, diagnosed at age 45). She is currently taking Venlafaxine ER 75 mg daily and has stopped taking levothyroxine and Advil three weeks ago. She also takes B12 and a multivitamin daily. She has no known allergies or adverse reactions to medications. The patient had a cholecystectomy 2 years ago and a recent colonoscopy, which was normal.

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Arora's Assessment

What might be happening

Based on the symptoms and history you've provided, here are some possible explanations for your condition:

Diarrhea and Pain Under Right Ribs

  1. Post-Cholecystectomy Syndrome: Since you had your gallbladder removed two years ago, it's possible that your symptoms are related to post-cholecystectomy syndrome. This can include diarrhea and abdominal pain, particularly after eating fatty foods.
  2. Bile Acid Malabsorption: This condition can occur after gallbladder removal and can cause chronic diarrhea. It happens when bile acids are not properly reabsorbed in the intestines.
  3. Irritable Bowel Syndrome (IBS): IBS can cause chronic diarrhea and abdominal pain. Stress and dietary changes can exacerbate symptoms.
  4. Pancreatic Insufficiency: This condition can cause diarrhea and abdominal pain due to the pancreas not producing enough digestive enzymes.

Low GFR and High A1c

  1. Chronic Kidney Disease (CKD): A GFR of 42 indicates moderate kidney dysfunction. This could be related to your Hashimoto's disease or other underlying conditions.
  2. Diabetes or Prediabetes: An A1c of 7.6 suggests poor blood sugar control, which can affect kidney function. Even if you haven't been diagnosed with diabetes, this level is concerning and needs further evaluation.

What you can do

Diarrhea and Pain Under Right Ribs

  • Dietary Adjustments: Avoid fatty, spicy, and greasy foods that can exacerbate diarrhea and abdominal pain. Consider a low-fat diet.
  • Hydration: Ensure you stay well-hydrated, especially with chronic diarrhea. Drink plenty of water and consider oral rehydration solutions.
  • Over-the-Counter Medications: Anti-diarrheal medications like loperamide (Imodium) can help manage symptoms, but consult your doctor before use.
  • Medical Consultation: See a gastroenterologist for further evaluation. They may recommend bile acid binders or other treatments.

Low GFR and High A1c

  • Blood Sugar Management: Work with your healthcare provider to manage your blood sugar levels. This may involve lifestyle changes, medications, or insulin therapy.
  • Kidney Function Monitoring: Regularly monitor your kidney function with your healthcare provider. They may recommend dietary changes, medications, or other interventions to protect your kidneys.
  • Lifestyle Changes: Adopt a kidney-friendly diet, which includes reducing salt, protein, and phosphorus intake. Regular exercise and maintaining a healthy weight are also important.

General Tips

  • Symptom Tracking: Use MDandMe to journal your symptoms, track progress, and get insights. This can help you and your healthcare provider understand your condition better.
  • Regular Check-Ups: Schedule regular check-ups with your healthcare provider to monitor your conditions and adjust treatments as needed.

What you should look out for

Given the complexity of your symptoms, it's important to seek medical care promptly. Reasons to seek care more urgently include:

  • Severe Abdominal Pain: If your pain becomes severe or unbearable.
  • Signs of Dehydration: Such as dizziness, dry mouth, or reduced urine output.
  • Uncontrolled Blood Sugar: If you experience symptoms of high or low blood sugar, such as extreme thirst, frequent urination, confusion, or fainting.
  • Worsening Kidney Function: If you notice swelling, fatigue, or changes in urine output.

Remember, while I can provide information and suggestions, it's crucial to consult with real healthcare professionals for a formal diagnosis and treatment plan. If you have more questions or need further assistance, feel free to continue the conversation.

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5 mo ago

People Also Ask


What is post-cholecystectomy syndrome and how does it affect digestion?

Post-cholecystectomy syndrome refers to a group of symptoms that can occur after gallbladder removal, including abdominal pain and diarrhea. It can affect digestion because the gallbladder is no longer there to store bile, which can lead to changes in how bile is released into the intestines.


How can bile acid malabsorption cause diarrhea after gallbladder removal?

Bile acid malabsorption occurs when bile acids are not properly reabsorbed in the intestines after gallbladder removal, leading to excess bile acids in the colon. This can cause chronic diarrhea as the bile acids irritate the colon lining.


What are the implications of a high A1c and low GFR in someone without a diabetes diagnosis?

A high A1c indicates poor blood sugar control, which can be a sign of undiagnosed diabetes or prediabetes. A low GFR suggests reduced kidney function, which can be affected by high blood sugar levels. Both conditions require further evaluation and management to prevent complications.


What lifestyle changes can help manage symptoms of chronic kidney disease?

To manage chronic kidney disease, it's important to adopt a kidney-friendly diet, which includes reducing salt, protein, and phosphorus intake. Regular exercise, maintaining a healthy weight, and monitoring blood pressure and blood sugar levels are also crucial. Consulting with a healthcare provider for personalized advice is recommended.


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Arora (Bot)#28060

5 mo ago

Low B12 and low folate levels can contribute to various symptoms and health issues. B12 deficiency can cause fatigue, weakness, constipation, loss of appetite, and neurological issues like numbness and tingling in the hands and feet. Folate deficiency can lead to similar symptoms, including fatigue, mouth sores, and changes in skin, hair, or fingernail color. Both deficiencies can also contribute to anemia, which can exacerbate feelings of tiredness and weakness. It's important to address these deficiencies through diet or supplements as recommended by your healthcare provider. Given your recent start on B12 supplements, it may take some time to see improvements. You should discuss these lab results with your healthcare provider to determine the best course of action for managing these deficiencies.

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