[42F] With watery vaginal discharge and history of uterine fibroids

Patient Description

A 42-year-old female presents with a watery, light yellow vaginal discharge occurring throughout the day for the past few weeks. The discharge is not accompanied by any odor, itching, or discomfort. The patient has a history of uterine fibroids causing irregular periods and heavy bleeding. She recently started taking Orilissa 150 mg for her fibroids in September. The patient had a new sexual partner about a month ago, with protection used only the second time. She denies any pelvic pain, fever, chills, pain or burning during urination, unusual fatigue, or general feeling of being unwell. Her medical history includes high blood pressure, high cholesterol, and low potassium, for which she is taking Rosuvastatin 5mg and Potassium Chloride 20meq. No known drug allergies.

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Arora's Assessment

What might be happening

Based on the information you have provided, here are some possible explanations for your symptoms:

  • Hormonal Changes Due to Orilissa: Orilissa (elagolix) is a medication used to manage pain associated with uterine fibroids. It works by altering hormone levels, which can sometimes lead to changes in vaginal discharge. Watery discharge without odor or irritation can be a side effect of hormonal changes.

    • Typical Treatments/Testing: Your doctor may monitor your symptoms and adjust your medication if necessary. They might also perform a pelvic exam or other tests to rule out infections or other conditions.
  • Physiological Discharge: It is normal for vaginal discharge to vary in consistency and amount throughout the menstrual cycle. Watery discharge can be a normal part of this cycle, especially if there are no other symptoms like itching, odor, or discomfort.

    • Typical Treatments/Testing: No specific treatment is needed if the discharge is physiological. However, if you are concerned, a healthcare provider can perform a pelvic exam to ensure everything is normal.
  • Sexually Transmitted Infections (STIs): Given the recent unprotected sexual encounter, it is important to consider the possibility of an STI, even though you do not have other symptoms like itching or odor.

    • Typical Treatments/Testing: Your doctor may recommend STI screening tests to rule out infections like chlamydia or gonorrhea. Treatment would depend on the specific infection, if any.

What you can do

While it's important to consult a healthcare provider for a formal diagnosis and treatment plan, here are some steps you can take in the meantime:

  1. Monitor Your Symptoms: Keep track of your symptoms, including the amount, color, and consistency of the discharge. Note any changes or new symptoms.
  2. Maintain Good Hygiene: Ensure you are practicing good genital hygiene. Use mild, unscented soap and water to clean the area.
  3. Stay Hydrated: Drink plenty of water to help maintain overall health.
  4. Use MDandMe: Utilize the MDandMe app to journal your symptoms, track your progress, and get insights. This can be helpful information to share with your healthcare provider.

What you should look out for

Seek medical attention if you notice any of the following:

  • Increased Discharge: If the amount of discharge significantly increases or changes in color or consistency.
  • New Symptoms: If you develop itching, burning, odor, or discomfort.
  • Pelvic Pain: If you experience any pelvic pain or discomfort.
  • Fever or Chills: If you develop a fever or chills, which could indicate an infection.
  • Irregular Bleeding: If you notice any unusual bleeding or spotting.

Remember, while I can provide information and suggestions, it's important to consult a healthcare professional for a formal diagnosis and appropriate treatment.

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8 mo ago

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People Also Ask


Can Orilissa cause changes in vaginal discharge?

Yes, Orilissa can cause changes in vaginal discharge as it alters hormone levels. Watery discharge without odor or irritation can be a side effect of these hormonal changes.


Is watery vaginal discharge without odor or discomfort normal?

Yes, watery vaginal discharge without odor or discomfort can be normal and part of the physiological changes throughout the menstrual cycle. However, if you are concerned, it's best to consult a healthcare provider.


Should I be concerned about a sexually transmitted infection (STI) after a recent unprotected sexual encounter?

Yes, it is important to consider the possibility of an STI after a recent unprotected sexual encounter, even if there are no other symptoms. It is advisable to get screened for STIs to rule out any infections.


What symptoms should prompt me to seek medical attention regarding vaginal discharge?

You should seek medical attention if you notice an increase in discharge, changes in color or consistency, new symptoms like itching, burning, odor, or discomfort, pelvic pain, fever, chills, or unusual bleeding or spotting.


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