[42F] With persistent fatigue, LUQ pain, and lymphadenopathy

What might be happening

Based on the symptoms and history you've shared, there are a few potential explanations for what you might be experiencing:

1. Lymphoma or another type of blood cancer: Given your family history of lymphoma and the presence of swollen lymph nodes, weight loss, night sweats, and fatigue, it's important to consider the possibility of a blood cancer. These symptoms are concerning and warrant further investigation by a healthcare professional. Typical testing might include blood tests, imaging studies like a CT or PET scan, and possibly a biopsy of the lymph nodes.

2. Infection or inflammatory condition: Elevated white blood cells and eosinophils can sometimes indicate an infection or an inflammatory condition. However, given the chronic nature of your symptoms and the presence of an enlarged spleen, this is less likely to be the sole cause.

3. Autoimmune disorder: Although your ANA test was negative, some autoimmune disorders can present with similar symptoms, including fatigue, swollen lymph nodes, and skin rashes. Further testing might be needed to explore this possibility.

What you can do

Swollen lymph nodes and fatigue: It's crucial to see a healthcare provider as soon as possible to evaluate these symptoms further. They may recommend additional tests to determine the underlying cause. In the meantime, try to:

• Rest as much as possible and prioritize sleep.
• Maintain a balanced diet to support your immune system.
• Use MDandMe to journal your symptoms, track progress, and share insights with your healthcare provider.

LUQ pain and back pain: While waiting for a medical evaluation, you can:

• Apply a warm compress to the affected areas to help alleviate pain.
• Consider over-the-counter pain relief, such as acetaminophen, if approved by your doctor.
• Avoid activities that exacerbate the pain.

Night sweats and skin rash: To manage these symptoms:

• Keep your bedroom cool and wear breathable fabrics to bed.
• Use a gentle, fragrance-free moisturizer on your skin to help with itching.
• Avoid hot showers, which can worsen skin irritation.

What you should look out for

Given the potential seriousness of your symptoms, it's important to seek medical care promptly. Be vigilant for any of the following:

• Rapidly enlarging lymph nodes or new areas of swelling.
• Persistent or worsening fevers.
• Unexplained bruising or bleeding.
• Severe shortness of breath or chest pain.

Remember, while I can provide information and guidance, it's essential to consult with a healthcare professional for a formal diagnosis and appropriate treatment.