[40F] Experiencing severe bone pain, dry mouth, and other symptoms

Patient Description

A 40-year-old female presents with significant bone pain in the legs, arms, and ribs, which has been worsening over the past few weeks. The pain is constant throughout the day and is rated as a 7 out of 10 in intensity. Applying steady pressure provides some relief. The patient denies any recent injuries or trauma. Additionally, she reports a persistent dry mouth, increased thirst, frequent urination, weight gain, significant changes in vision, and numbness or tingling in the hands and feet. The patient smokes approximately a pack and a half a day and uses amphetamines (approximately 0.5 units, 3 to 4 times a day). She has no known family history of diabetes or other chronic illnesses and is not taking any other prescribed medications or substances.

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Arora's Assessment

What might be happening

Based on the symptoms you've described, here are some possible explanations:

1. Diabetes

  • Rationale: Your symptoms of increased thirst, frequent urination, weight gain, and significant changes in vision are classic signs of diabetes. The numbness and tingling in your hands and feet could also be related to diabetic neuropathy, a common complication of diabetes.
  • Typical Testing and Treatment: Blood tests such as fasting blood glucose, HbA1c, and an oral glucose tolerance test can help diagnose diabetes. Treatment typically involves lifestyle changes, medications to control blood sugar levels, and regular monitoring.

2. Bone Pain and Possible Osteoporosis or Bone Disease

  • Rationale: Persistent bone pain, especially when it worsens over time, could be indicative of osteoporosis or another bone-related condition. The fact that applying pressure relieves some pain might suggest a musculoskeletal issue.
  • Typical Testing and Treatment: A bone density scan (DEXA) can help diagnose osteoporosis. Blood tests, X-rays, or other imaging studies might be needed to rule out other bone diseases. Treatment may include medications to strengthen bones, calcium and vitamin D supplements, and lifestyle changes.

3. Dehydration and Electrolyte Imbalance

  • Rationale: Your dry mouth and constant thirst could be signs of dehydration or an electrolyte imbalance, possibly exacerbated by smoking and amphetamine use.
  • Typical Testing and Treatment: Blood tests to check electrolyte levels and kidney function can help diagnose this. Treatment involves rehydration and possibly electrolyte supplements.

4. Substance Use Effects

  • Rationale: The use of amphetamines can lead to a range of symptoms, including dry mouth, increased thirst, and changes in weight and appetite. Long-term use can also affect bone health and overall well-being.
  • Typical Testing and Treatment: A comprehensive evaluation by a healthcare provider is necessary. Treatment may involve substance use counseling, support groups, and medical management of withdrawal symptoms.

What you can do

Bone Pain

  • See a doctor: It's important to get a proper diagnosis for your bone pain. Your doctor may recommend imaging tests or refer you to a specialist.
  • At home: Apply steady pressure or use a heating pad to relieve pain. Over-the-counter pain relievers like ibuprofen can also help, but use them as directed.

Increased Thirst and Frequent Urination

  • See a doctor: These symptoms are concerning for diabetes. Your doctor will likely perform blood tests to check your blood sugar levels.
  • At home: Stay hydrated with water and avoid sugary drinks. Monitor your symptoms and note any changes.

Dry Mouth

  • See a doctor: This could be related to dehydration, diabetes, or side effects of smoking and amphetamines.
  • At home: Chew sugar-free gum or suck on sugar-free candies to stimulate saliva production. Drink plenty of water throughout the day.

Numbness and Tingling

  • See a doctor: These symptoms could be related to diabetes or another neurological condition.
  • At home: Avoid prolonged pressure on your hands and feet. Gentle exercises and stretching can help improve circulation.

Substance Use

  • See a doctor: It's important to discuss your amphetamine use with a healthcare provider. They can provide resources and support for substance use management.
  • At home: Consider seeking support from friends, family, or support groups. Reducing or quitting smoking can also improve your overall health.

What you should look out for

Given the severity of your symptoms, you should seek medical care as soon as possible. Reasons to seek care even more urgently include:

  • Severe or worsening pain: If your bone pain becomes unbearable or is accompanied by swelling or redness.
  • Signs of high blood sugar: Such as extreme thirst, frequent urination, unexplained weight loss, or fatigue.
  • Neurological symptoms: Such as severe numbness, tingling, or weakness in your limbs.
  • Vision changes: If you experience sudden or severe changes in your vision.

Remember, while I can provide information and suggestions, it's crucial to consult with a healthcare professional for a formal diagnosis and appropriate treatment. You can use MDandMe to journal your symptoms, track progress, get insights, and share longitudinal medical notes with your provider.

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7 mo ago

People Also Ask


What are the common symptoms of diabetes that I should be aware of?

Common symptoms of diabetes include increased thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and numbness or tingling in the hands and feet. If you experience these symptoms, it's important to consult a healthcare provider for testing.


How can smoking and amphetamine use affect my bone health?

Smoking can reduce bone density and increase the risk of fractures, while amphetamine use can lead to nutritional deficiencies and affect bone metabolism. Both can contribute to poor bone health over time.


What tests are typically used to diagnose osteoporosis or other bone diseases?

To diagnose osteoporosis or other bone diseases, doctors typically use a bone density scan (DEXA). Additional tests may include blood tests, X-rays, or other imaging studies to assess bone health and rule out other conditions.


What are the potential side effects of long-term amphetamine use?

Long-term amphetamine use can lead to a range of side effects, including cardiovascular issues, mental health problems, weight loss, dental problems, and potential impacts on bone health. It is important to discuss any substance use with a healthcare provider.


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