[40F] Experiencing persistent nausea with complex medical history

Patient Description

A 40-year-old female presents with constant nausea that has been worsening over the past few years, coinciding with an increase in water consumption due to diabetes insipidus and type 2 diabetes. The patient experiences frequent urination, extreme thirst, and fluctuations in blood sugar levels. Despite these symptoms, there is no vomiting or blood present. The patient also suffers from shortness of breath, a rapid heart rate, and was recently diagnosed with cellulitis. Her extensive medical history includes high cholesterol, obesity, underactive thyroid, sleep apnea, bipolar depression, fibromyalgia, arthritis, acid reflux, anxiety, memory loss, and other mental health issues, with diagnoses established over five years ago. She is allergic to certain birth control and antidepressants. Current medications include Metformin, Jardiance, Pregabalin, thyroid medication, Lorazepam, and weekly EpiPen injections. The patient has difficulty recalling all medications due to the extensive list.

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Arora's Assessment

What might be happening

Based on the information you've provided, the following conditions could be contributing to your symptoms:

  • Gastroparesis: This condition, which causes delayed stomach emptying, can lead to chronic nausea and vomiting. It's often associated with diabetes, which you mentioned you have.

    • Treatment typically involves dietary changes, medication to help the stomach empty more quickly, and, in severe cases, feeding tubes or intravenous feeding.
  • Diabetic ketoacidosis (DKA): This is a serious complication of diabetes that occurs when your body has low insulin levels and starts to use fat as an energy source, which produces ketones. High levels of ketones can lead to nausea, vomiting, and abdominal pain. Given your history of type 2 diabetes and the symptoms you've described, DKA could be a possibility.

    • Treatment involves insulin therapy, fluid and electrolyte replacement, and treating the underlying cause.
  • Gastroesophageal reflux disease (GERD): This is a chronic condition where stomach acid frequently flows back into the tube connecting your mouth and stomach (esophagus). This backwash (acid reflux) can irritate the lining of your esophagus and cause nausea.

    • Treatment typically involves lifestyle changes and over-the-counter medication. If these don't help, your doctor might recommend prescription medication or surgery.

Please remember that this is not a comprehensive list of all possible conditions, and these conditions might not explain all of your symptoms.

What you can do

Given the complexity of your symptoms and medical history, it's important to consult with a healthcare provider for a comprehensive evaluation. They can order relevant tests, provide a formal diagnosis, and develop a treatment plan tailored to your needs.

In the meantime, here are some general tips that might help:

  1. Try to eat smaller, more frequent meals instead of three large meals a day.
  2. Avoid foods that are high in fat and fiber, as they can slow digestion and make gastroparesis worse.
  3. Stay hydrated by drinking plenty of water, but try to do so between meals instead of with meals.
  4. If you smoke, quit. Smoking can worsen symptoms of many gastrointestinal disorders.
  5. Try to maintain a healthy weight. Obesity can worsen symptoms of many gastrointestinal disorders.
  6. Monitor your blood glucose levels regularly and take your diabetes medications as prescribed.

What you should look out for

Please seek immediate medical attention if you experience any of the following:

  • Severe abdominal pain
  • Blood in your vomit or stool
  • Sudden, severe headache
  • Chest pain
  • Difficulty breathing
  • Confusion or difficulty staying awake
  • Fainting or loss of consciousness

These could be signs of a serious condition that needs immediate treatment.

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1 yr ago

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People Also Ask


What is gastroparesis and how is it related to diabetes?

Gastroparesis is a condition where the stomach takes too long to empty its contents, leading to symptoms like nausea and vomiting. It is often associated with diabetes because high blood sugar levels can damage the vagus nerve, which controls stomach muscles.


How can diabetic ketoacidosis (DKA) affect someone with type 2 diabetes?

Diabetic ketoacidosis (DKA) is a serious complication that occurs when the body starts breaking down fat too quickly due to low insulin levels, leading to the production of ketones. This can cause nausea, vomiting, and abdominal pain, and requires immediate medical treatment.


What lifestyle changes can help manage gastroesophageal reflux disease (GERD)?

To manage GERD, lifestyle changes such as eating smaller meals, avoiding foods that trigger reflux (like spicy or fatty foods), not lying down immediately after eating, and maintaining a healthy weight can be helpful.


What are the potential side effects of taking multiple medications for chronic conditions?

Taking multiple medications can lead to side effects such as interactions between drugs, increased risk of side effects from each medication, and difficulty in managing the medication regimen. It's important to regularly review medications with a healthcare provider to minimize risks.


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