[40F] Experiencing dizziness, chest tightness, and other symptoms post-eating

Patient Description

A 40-year-old female presents with sudden onset of dizziness described as lightheadedness with a bit of spinning, rated 7 out of 10 in severity. The dizziness worsens with movement and is relieved by antihistamines. The patient also experiences moderate to severe shortness of breath, moderate chest tightness described as squeezing, and tingling under the tongue and near the corners of the lips, all occurring after eating. Additional symptoms include nasal congestion, post-nasal drip, an aching headache in the sinus area and occasionally the back of the head rated 5 out of 10, and moderate weakness. The patient reports a red, splotchy rash with red bumps on the arms after eating certain foods. Symptoms began 7 months ago after taking doxycycline. The patient has a history of inappropriate sinus tachycardia and postural orthostatic tachycardia syndrome diagnosed in March 2024, and possible mast cell activation syndrome and dysautonomia. Current medications include Metoprolol 100 mg daily, Lexapro 20 mg nightly, Famotidine 20 mg twice daily, Cetirizine 10 mg twice daily, Hydroxyzine 20 mg as needed, and Benadryl 50 mg as needed, usually twice a day. The patient has a possible allergy or intolerance to doxycycline.

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Arora's Assessment

What might be happening

Based on the symptoms and history you've provided, here are some possible explanations:

1. Mast Cell Activation Syndrome (MCAS)

  • Rationale: MCAS can cause a variety of symptoms, including dizziness, shortness of breath, chest tightness, tingling in the mouth, nasal congestion, post-nasal drip, headaches, and rashes. These symptoms often occur after exposure to certain triggers, such as foods, medications, or environmental factors.
  • Typical Treatments/Testing: Diagnosis often involves blood tests to measure tryptase levels, urine tests for histamine metabolites, and sometimes a skin biopsy. Treatment usually includes antihistamines (which you are already taking), mast cell stabilizers, and avoiding known triggers.

2. Allergic Reaction or Food Intolerance

  • Rationale: The sudden onset of symptoms after eating, including dizziness, shortness of breath, chest tightness, and tingling in the mouth, suggests a possible allergic reaction or food intolerance. The red, splotchy rash and bumps on your arms further support this.
  • Typical Treatments/Testing: Allergy testing (skin prick tests or blood tests) can help identify specific allergens. Treatment involves avoiding the triggering foods and using antihistamines or other medications to manage symptoms.

3. Dysautonomia (including POTS and IST)

  • Rationale: Dysautonomia can cause dizziness, weakness, and headaches, especially after eating. Your history of inappropriate sinus tachycardia (IST) and postural orthostatic tachycardia syndrome (POTS) supports this.
  • Typical Treatments/Testing: Management includes lifestyle changes, such as increasing fluid and salt intake, wearing compression stockings, and medications to manage heart rate and blood pressure.

What you can do

Dizziness, Shortness of Breath, and Chest Tightness

  • Immediate Action: Given the severity of these symptoms, especially the shortness of breath and chest tightness, you should seek medical attention as soon as possible. These could be signs of a serious allergic reaction or other urgent condition.
  • At Home: Continue taking your antihistamines as prescribed. Try to identify and avoid any potential food triggers. Keep a detailed journal of your symptoms, including what you ate before the symptoms started, using MDandMe to track your progress and share with your healthcare provider.

Tingling in Mouth and Rash

  • Immediate Action: If the tingling or rash worsens or you experience swelling of the face, lips, or throat, seek emergency medical care immediately.
  • At Home: Avoid known triggers and continue taking antihistamines. Use MDandMe to document any new triggers or changes in your symptoms.

Headache and Weakness

  • Immediate Action: Consult your healthcare provider to discuss these ongoing symptoms, especially since they have been persistent for several months.
  • At Home: Ensure you are staying hydrated and maintaining a balanced diet. Keep a symptom journal using MDandMe to track any patterns or triggers.

What you should look out for

Given the complexity and severity of your symptoms, it's important to seek medical care as soon as possible. Reasons to seek care even more urgently include:

  • Severe allergic reaction: Swelling of the face, lips, or throat, difficulty breathing, or a severe rash.
  • Severe dizziness or fainting: Especially if it occurs suddenly or is accompanied by other severe symptoms.
  • Worsening chest tightness or shortness of breath: These could be signs of a serious condition that needs immediate attention.

Remember, while I can provide information and suggestions, it's crucial to consult with a healthcare professional for a formal diagnosis and appropriate treatment.

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4 mo ago


People Also Ask


What is Mast Cell Activation Syndrome (MCAS) and how is it diagnosed?

Mast Cell Activation Syndrome (MCAS) is a condition where mast cells release excessive amounts of chemicals like histamine, leading to symptoms such as dizziness, shortness of breath, and rashes. Diagnosis often involves blood tests for tryptase levels, urine tests for histamine metabolites, and sometimes a skin biopsy. Treatment includes antihistamines, mast cell stabilizers, and avoiding known triggers.


How can I differentiate between an allergic reaction and food intolerance?

An allergic reaction typically involves the immune system and can cause symptoms like hives, swelling, and anaphylaxis, while food intolerance usually results in digestive issues without involving the immune system. Allergy testing, such as skin prick tests or blood tests, can help identify specific allergens.


What are the common symptoms and management strategies for dysautonomia, including POTS and IST?

Dysautonomia, including Postural Orthostatic Tachycardia Syndrome (POTS) and Inappropriate Sinus Tachycardia (IST), can cause symptoms like dizziness, weakness, and headaches. Management includes lifestyle changes like increasing fluid and salt intake, wearing compression stockings, and medications to manage heart rate and blood pressure.


What should I do if I experience severe allergic reactions or worsening symptoms?

If you experience severe allergic reactions, such as swelling of the face, lips, or throat, or difficulty breathing, seek emergency medical care immediately. For worsening symptoms like severe dizziness or chest tightness, consult a healthcare professional as soon as possible.


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