[39F] With delayed menstruation and associated symptoms

Patient Description

A 39-year-old female presents with a 16-day delay in menstruation, despite a negative pregnancy test. She reports experiencing swollen and painful breasts, mild cramping in the legs, feet, and back, as well as nausea and difficulty breathing. The cramps are described as medium in severity and tend to occur in the afternoon, with some relief provided by massage. Additionally, the patient notes an increase in urinary frequency. There have been no recent lifestyle changes, stressors, or alterations in diet or physical activity. The patient denies any recent weight changes, mood alterations, or changes in hair or skin. She has no significant medical history, family history of hormonal or reproductive issues, or known allergies. The only supplements taken are vitamins.

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Arora's Assessment

What might be happening

Based on the symptoms you've described, here are some possible explanations:

  • Hormonal Imbalance: Delayed periods, breast tenderness, and nausea can sometimes be attributed to hormonal imbalances. This can occur due to stress, changes in weight, or other factors affecting your hormonal cycle. Hormonal imbalances can also cause leg and back cramps.

  • Premenstrual Syndrome (PMS): PMS can cause symptoms such as breast tenderness, bloating, cramps, and mood changes. It typically occurs in the days leading up to your period.

  • Early Pregnancy: Although your pregnancy test was negative, it's possible to have a false negative, especially if taken too early. Symptoms like breast tenderness, nausea, and missed periods are common in early pregnancy.

  • Thyroid Issues: Thyroid disorders can cause a range of symptoms, including changes in menstrual cycle, fatigue, and muscle cramps.

  • Nutritional Deficiencies: Deficiencies in certain vitamins and minerals, such as magnesium or calcium, can lead to muscle cramps and fatigue.

What you can do

  1. Consult a Healthcare Provider: It's important to discuss your symptoms with a healthcare provider to rule out any underlying conditions and to consider further testing if necessary.

  2. Track Your Symptoms: Use MDandMe to journal your symptoms, track your menstrual cycle, and note any changes. This information can be helpful for your healthcare provider.

  3. Lifestyle Adjustments: Ensure you're getting adequate rest, staying hydrated, and maintaining a balanced diet. Consider incorporating foods rich in magnesium and calcium to help with cramps.

  4. Over-the-Counter Relief: Over-the-counter pain relievers may help alleviate cramps and breast tenderness. However, consult with a healthcare provider before starting any new medication.

What you should look out for

  • Seek Immediate Care: If you experience severe pain, heavy bleeding, or difficulty breathing, seek medical attention promptly.

  • Monitor Symptoms: Keep an eye on your symptoms, especially if they worsen or new symptoms develop.

  • Follow Up on Pregnancy Testing: If your period does not start soon, consider retaking a pregnancy test or consulting with a healthcare provider for further evaluation.

Remember, while this information can be helpful, it's important to seek care from a healthcare professional for a formal diagnosis and appropriate treatment.

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2 mo ago

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People Also Ask


Can a negative pregnancy test be inaccurate, and should I retest if my period is delayed?

Yes, a negative pregnancy test can sometimes be inaccurate, especially if taken too early. If your period is delayed, it may be worth retesting after a few days or consulting with a healthcare provider for further evaluation.


What are common causes of hormonal imbalances that could delay menstruation?

Common causes of hormonal imbalances include stress, significant changes in weight, thyroid disorders, and certain medications. These imbalances can affect your menstrual cycle and lead to symptoms like delayed periods and breast tenderness.


How can nutritional deficiencies lead to symptoms like muscle cramps and fatigue?

Nutritional deficiencies, particularly in magnesium and calcium, can lead to muscle cramps and fatigue. These minerals are essential for muscle function and energy production, and a lack of them can cause symptoms like cramping and tiredness.


What are the signs that indicate I should seek immediate medical attention for my symptoms?

You should seek immediate medical attention if you experience severe pain, heavy bleeding, or difficulty breathing. These could be signs of a more serious condition that requires prompt evaluation by a healthcare professional.


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