[38M] With leg swelling, fatigue, and gastrointestinal symptoms

Patient Description

A 38-year-old male presents with sudden onset of soft swelling in the legs persisting for three weeks, accompanied by fatigue, trouble sleeping, diarrhea, and loss of appetite. The patient reports diarrhea occurring every few days, with stools that are light brown and have a strong odor. There is no recent travel history, and no known triggers for insomnia or diarrhea have been identified. The patient denies any yellowing of the skin or eyes, shortness of breath, or abdominal pain. There is no history of heart or kidney issues, but the patient was diagnosed with Hepatitis C two months ago and has a longstanding history of Lyme disease from 26 years ago. The patient does not consume alcohol, has no family history of liver disease, and is not currently on any medications. No allergies or adverse reactions to medications are reported. The patient's weight has remained stable.

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Arora's Assessment

What might be happening

Based on the symptoms you've described, there are a few potential explanations:

  1. Hepatitis C Complications: Given your recent diagnosis of Hepatitis C, it's possible that your symptoms, particularly the leg swelling, fatigue, and changes in stool color, could be related to liver function issues. Hepatitis C can lead to liver inflammation, which might cause fluid retention (swelling) and changes in digestion.

  2. Nutritional Deficiencies or Malabsorption: The diarrhea and loss of appetite could be contributing to nutritional deficiencies, which might exacerbate fatigue and other symptoms. Malabsorption issues can also lead to changes in stool color and consistency.

  3. Chronic Lyme Disease Effects: Although Lyme disease was diagnosed many years ago, some individuals experience long-term symptoms that can include fatigue and sleep disturbances.

Typical treatments or testing might include liver function tests to assess the impact of Hepatitis C, nutritional assessments, and possibly imaging studies to evaluate liver health.

What you can do

Swollen Legs and Fatigue:

  • See a healthcare provider: It's important to have your liver function evaluated given your Hepatitis C diagnosis. Your doctor may recommend blood tests or imaging studies.
  • Elevate your legs: When resting, try to keep your legs elevated to help reduce swelling.
  • Stay hydrated: Ensure you're drinking enough fluids, especially if you're experiencing diarrhea.

Trouble Sleeping:

  • Establish a bedtime routine: Try to go to bed and wake up at the same time each day. Avoid screens and caffeine before bed.
  • Relaxation techniques: Consider relaxation exercises or meditation to help improve sleep quality.

Diarrhea and Loss of Appetite:

  • Monitor your diet: Keep track of foods that might be triggering symptoms. Eating smaller, more frequent meals might help.
  • Stay hydrated: Ensure you're drinking enough fluids to prevent dehydration from diarrhea.

Consider using MDandMe to journal your symptoms, track progress, and share insights with your healthcare provider.

What you should look out for

Seek medical attention if you experience any of the following:

  • Yellowing of the skin or eyes (jaundice)
  • Severe abdominal pain
  • Significant weight loss
  • Persistent or worsening symptoms

It's important to consult with a healthcare professional to receive a formal diagnosis and appropriate treatment.

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28 d ago


People Also Ask


What are the common symptoms of Hepatitis C complications?

Common symptoms of Hepatitis C complications include fatigue, jaundice, abdominal pain, swelling in the legs or abdomen, and changes in stool color. These symptoms are often related to liver inflammation and impaired liver function.


How can nutritional deficiencies affect my health?

Nutritional deficiencies can lead to a variety of health issues, including fatigue, weakened immune function, poor concentration, and changes in skin, hair, and nail health. They can also exacerbate existing conditions and contribute to symptoms like diarrhea and loss of appetite.


Can Lyme disease cause long-term symptoms even after many years?

Yes, some individuals with a history of Lyme disease may experience long-term symptoms, known as Post-Treatment Lyme Disease Syndrome (PTLDS), which can include fatigue, joint pain, and sleep disturbances, even years after the initial infection.


What lifestyle changes can help manage insomnia?

To manage insomnia, establish a consistent sleep schedule, create a relaxing bedtime routine, avoid caffeine and electronic screens before bed, and consider relaxation techniques such as meditation or deep breathing exercises to improve sleep quality.

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