[35F] With persistent fatigue for over a year

Patient Description

A 35-year-old female reports experiencing persistent fatigue for the past year, which is most pronounced in the morning and improves slightly by nighttime. The fatigue significantly impacts her ability to complete daily chores but is not associated with other symptoms such as headaches, dizziness, trouble sleeping, weight changes, or dietary changes. She denies any recent illnesses, infections, travel, stress, or emotional challenges that could contribute to her symptoms. No known allergies or chronic conditions reported. Further evaluation is recommended to identify potential underlying causes, such as thyroid dysfunction, anemia, or chronic fatigue syndrome.

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Arora's Assessment

What might be happening

Based on the information you've provided, your persistent fatigue over the past year could be due to several possible causes. Here are the most likely explanations:

  1. Chronic Fatigue Syndrome (CFS): This condition is characterized by long-term, unexplained fatigue that doesn’t improve with rest and significantly impacts daily life. Since your fatigue has persisted for a year and affects your ability to complete chores, CFS could be a possibility. Diagnosis often involves ruling out other conditions, as there is no specific test for CFS. Treatment typically focuses on managing symptoms through lifestyle changes, stress reduction, and sometimes medications.

  2. Hypothyroidism: An underactive thyroid can cause fatigue, especially in the morning, along with other symptoms like weight changes, cold intolerance, and dry skin. While you haven’t reported these additional symptoms, hypothyroidism is a common cause of fatigue and can be diagnosed with a simple blood test. Treatment involves thyroid hormone replacement therapy.

  3. Vitamin Deficiencies: Deficiencies in vitamins like B12 or D (or iron) can lead to fatigue. These deficiencies are common and can be identified through blood tests. Treatment involves dietary changes or supplements.

  4. Sleep Disorders: Even if you haven’t noticed changes in your sleep patterns, conditions like sleep apnea or poor sleep quality can cause morning fatigue. A sleep study may be needed to rule this out.

  5. Mental Health Factors: Conditions like depression or anxiety can sometimes manifest as fatigue, even if you don’t feel sad or stressed. This is worth considering if other causes are ruled out.


What you can do

Here are some steps you can take to manage your fatigue and work toward identifying the cause:

  1. Consult a Doctor: Schedule an appointment with a healthcare provider to discuss your symptoms. They may recommend blood tests to check for thyroid function, vitamin levels, and anemia, or suggest a sleep study.

  2. Track Your Symptoms: Use MDandMe to journal your fatigue levels, sleep patterns, diet, and daily activities. This can help identify triggers or patterns and provide valuable information for your doctor.

  3. Optimize Your Sleep:

    • Stick to a consistent sleep schedule.
    • Create a sleep-friendly environment (dark, quiet, cool room).
    • Avoid screens and caffeine before bed.
  4. Focus on Nutrition:

    • Eat a balanced diet rich in whole foods, lean proteins, fruits, and vegetables.
    • Stay hydrated by drinking plenty of water throughout the day.
    • Consider a multivitamin if you suspect deficiencies, but consult your doctor first.
  5. Incorporate Gentle Activity:

    • Start with light exercises like walking or yoga to boost energy levels.
    • Avoid overexertion, as it can worsen fatigue.
  6. Manage Stress:

    • Practice mindfulness or meditation to reduce mental fatigue.
    • Break tasks into smaller steps to avoid feeling overwhelmed.

What you should look out for

Here are some warning signs that may require more urgent medical attention:

  • Sudden worsening of fatigue or inability to perform basic tasks.
  • Unexplained weight changes, either gain or loss.
  • New symptoms like dizziness, headaches, or shortness of breath.
  • Signs of anemia: Pale skin, rapid heartbeat, or feeling faint.
  • Sleep disturbances: Waking up frequently or feeling unrefreshed despite adequate sleep.

If any of these occur, or if your fatigue continues to worsen, consult a healthcare provider promptly.


Remember, I’m here to support you, but I’m not a doctor. It’s important to seek care from a medical professional to receive a formal diagnosis and treatment plan. Let me know if you’d like help preparing for your doctor’s visit or tracking your symptoms!

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13 d ago

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People Also Ask


What are common causes of persistent fatigue?

Persistent fatigue can be caused by conditions such as chronic fatigue syndrome, hypothyroidism, vitamin deficiencies, sleep disorders, or mental health issues.


How is hypothyroidism diagnosed and treated?

Hypothyroidism is diagnosed through blood tests measuring thyroid hormone levels and is treated with thyroid hormone replacement therapy.


Can vitamin deficiencies lead to fatigue?

Yes, deficiencies in vitamins like B12, D, or iron can lead to fatigue and are typically addressed with dietary changes or supplements.


What lifestyle changes can help manage chronic fatigue?

Lifestyle changes such as maintaining a consistent sleep schedule, eating a balanced diet, staying hydrated, and incorporating light exercise can help manage chronic fatigue.


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