[34M] With tremors, fatigue, muscle weakness, and tendon pain

Patient Description

A 34-year-old male presents with daily tremors in the arms, hands, and legs, described as shaking, which have been occurring for the past year. The tremors worsen with physical exertion and heat and are alleviated by rest. The patient also reports fatigue, muscle weakness, tendon pain, muscle stiffness, slowness of movement, poor balance, a softer voice, and reduced sense of smell. The tremors started suddenly and are more noticeable at rest after movement. The patient has difficulty with fine motor tasks and experiences increased mental effort to control movements. The patient has a history of asthma diagnosed in childhood, premature atrial contractions (PAC), and allergies. Current medications include Bupropion, Zoloft, Allegra, Breo Ellipta, Nasacort, and Azelastine. The patient consumes alcohol a few times a month and drinks coffee in the morning. There is no family history of neurological disorders and no recent travel to areas with potential exposure to infections or toxins.

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Arora's Assessment

What might be happening

Based on the symptoms you've described, here are some possible explanations:

Tremors, Fatigue, Muscle Weakness, and Tendon Pain

  1. Parkinson's Disease:

    • Rationale: Parkinson's disease often presents with tremors, muscle stiffness, slowness of movement, and balance issues. The fact that your tremors worsen with physical exertion and heat, and you experience muscle stiffness and a softer voice, aligns with common symptoms of Parkinson's.
    • Typical Treatments/Testing: Diagnosis usually involves a neurological examination and may include imaging tests like an MRI. Treatment often includes medications like Levodopa and physical therapy.
  2. Essential Tremor:

    • Rationale: Essential tremor is a neurological disorder that causes involuntary and rhythmic shaking, especially noticeable in the hands and arms. It can worsen with movement and improve with rest.
    • Typical Treatments/Testing: Diagnosis is primarily clinical, based on symptoms and family history. Treatment may include medications like beta-blockers or anticonvulsants.

Unifying Diagnoses

  1. Medication Side Effects:

    • Rationale: Both Bupropion and Zoloft can cause tremors and muscle weakness as side effects. The sudden onset of your symptoms could be related to these medications.
    • Typical Treatments/Testing: Your doctor may review your medications and possibly adjust dosages or switch medications.
  2. Thyroid Dysfunction:

    • Rationale: Thyroid issues can cause tremors, fatigue, muscle weakness, and tendon pain. Hyperthyroidism, in particular, can lead to these symptoms.
    • Typical Treatments/Testing: Blood tests to check thyroid hormone levels (TSH, T3, T4) are typically done. Treatment may involve medications, radioactive iodine, or surgery.

What you can do

Tremors, Fatigue, Muscle Weakness, and Tendon Pain

  1. See a Doctor:

    • Given the severity and duration of your symptoms, it's important to consult a healthcare professional for a thorough evaluation. They may refer you to a neurologist for specialized care.
  2. Medication Review:

    • Discuss your current medications with your doctor to see if they could be contributing to your symptoms. They may adjust your dosages or switch medications.
  3. Lifestyle Adjustments:

    • Rest: Continue to rest when needed, especially after physical exertion.
    • Hydration: Stay well-hydrated, especially in hot conditions.
    • Balanced Diet: Ensure you're getting a balanced diet rich in nutrients to support overall health.
  4. Physical Therapy:

    • Consider seeing a physical therapist to help manage muscle weakness and improve balance.
  5. Symptom Tracking:

    • Use MDandMe to journal your symptoms, track progress, get insights, and share longitudinal medical notes with your provider. This can help in identifying patterns and triggers.

What you should look out for

Given the complexity of your symptoms, it's important to seek medical care as soon as possible. Reasons to seek care even more urgently include:

  • Worsening Tremors: If your tremors become more severe or start affecting other parts of your body.
  • Severe Muscle Weakness: If you experience significant difficulty in performing daily activities.
  • Balance Issues: If you have frequent falls or severe balance problems.
  • Changes in Speech or Swallowing: If you notice significant changes in your speech or difficulty swallowing.

Remember, while I can provide information and suggestions, it's crucial to consult with a healthcare professional for a formal diagnosis and appropriate treatment.

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3 mo ago


People Also Ask


What are the common symptoms of Parkinson's disease?

Common symptoms of Parkinson's disease include tremors, muscle stiffness, slowness of movement, balance issues, a softer voice, and sometimes a reduced sense of smell.


How can essential tremor be distinguished from Parkinson's disease?

Essential tremor typically causes rhythmic shaking that is more noticeable during movement, whereas Parkinson's tremors are often more noticeable at rest. Essential tremor usually does not include other symptoms like muscle stiffness or slowness of movement.


Can medications like Bupropion and Zoloft cause tremors and muscle weakness?

Yes, both Bupropion and Zoloft can cause side effects such as tremors and muscle weakness. It's important to discuss these symptoms with your doctor, who may adjust your medication.


What are the signs of thyroid dysfunction that might relate to my symptoms?

Signs of thyroid dysfunction, particularly hyperthyroidism, can include tremors, fatigue, muscle weakness, and tendon pain. Blood tests measuring thyroid hormone levels can help diagnose thyroid issues.


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