[34M] With severe skin discoloration and unintentional weight loss

What might be happening

Based on the information you have provided, here are some possible explanations for your symptoms:

• Acanthosis Nigricans: This condition is characterized by dark, velvety patches of skin, often in body folds and creases such as the groin, knees, and elbows. It can be associated with insulin resistance, obesity, hormonal disorders, or certain medications. Given your unintentional weight loss, it might be worth exploring underlying metabolic or endocrine issues.

  • Typical Treatments: Treatment focuses on addressing the underlying condition. This may involve lifestyle changes, medications to manage insulin resistance, or treating any hormonal imbalances.

• Addison's Disease: This is an autoimmune disorder where the adrenal glands do not produce enough hormones. Symptoms can include darkening of the skin, weight loss, and cravings for salty foods. Although you haven't mentioned craving salty foods, the other symptoms align.

  • Typical Treatments: Treatment usually involves hormone replacement therapy to correct the levels of steroid hormones your body isn't producing.

• Cushing's Syndrome: This condition is caused by prolonged exposure to high levels of cortisol. Symptoms can include skin changes like stretch marks, weight changes, and a satin sheen to the skin. However, weight loss is less common with Cushing's.

  • Typical Treatments: Treatment may involve reducing corticosteroid use, surgery, radiation, or medications to control cortisol production.

• Nutritional Deficiencies: Rapid weight loss and changes in skin appearance can sometimes be linked to nutritional deficiencies, particularly if your diet has changed significantly.

  • Typical Treatments: Treatment involves dietary adjustments and possibly supplements to address any deficiencies.

What you can do

While it's important to consult a healthcare professional for a formal diagnosis and treatment plan, here are some steps you can take in the meantime:

1. Monitor Your Symptoms: Keep a detailed journal of your symptoms, including any changes in skin appearance, weight, and cravings. You can use MDandMe to track your symptoms, progress, and share this information with your healthcare provider.
2. Maintain a Balanced Diet: Ensure you are eating a well-balanced diet rich in fruits, vegetables, lean proteins, and whole grains. This can help address any potential nutritional deficiencies.
3. Stay Hydrated: Drink plenty of water, especially since you are craving juicy foods, which might indicate a need for more hydration.
4. Manage Stress: Since stress can exacerbate many conditions, try to incorporate stress-reducing activities into your routine, such as exercise, meditation, or hobbies you enjoy.
5. Avoid Irritants: Use gentle, fragrance-free skin care products to avoid further irritation to the affected areas.

What you should look out for

Seek medical attention if you notice any of the following:

• Rapid Progression: If the discoloration or stretch marks spread rapidly or worsen significantly.
• New Symptoms: If you develop new symptoms such as fatigue, muscle weakness, dizziness, or changes in appetite.
• Severe Weight Loss: If you continue to lose weight rapidly without trying.
• Other Concerns: Any other symptoms that cause you concern or affect your quality of life.

Remember, while I can provide information and suggestions, it's crucial to consult a healthcare professional for a formal diagnosis and appropriate treatment.