[34F] Experiencing frequent mood swings and fatigue

Patient Description

A 34-year-old female has been experiencing frequent mood swings for the past six months, particularly around her period, affecting her relationships with her spouse, children, and others. These mood swings occur 2-3 times a day and last around 30 minutes each time. She has not found anything that helps to relieve these mood swings. Additionally, she has been feeling unusually sleepy for the past one and a half years. She has noticed changes in her menstrual cycle, specifically that her periods are always late. Other symptoms include weight gain, dry skin, and feeling unusually cold compared to others. She has not experienced constipation or changes in bowel habits. Her thyroid levels have been checked and are normal. She is not currently taking any medications or supplements. She has a family history of diabetes on her maternal grandmother's side. She had her fallopian tubes removed three years ago and has no allergies or adverse reactions to any medications.

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Arora's Assessment

What might be happening

Based on the symptoms and history you've provided, here are some possible explanations for your condition:

1. Premenstrual Dysphoric Disorder (PMDD)

  • Rationale: PMDD is a severe form of premenstrual syndrome (PMS) that can cause significant mood swings, irritability, and other emotional symptoms in the luteal phase of your menstrual cycle (the time between ovulation and the start of your period). Given that your mood swings are closely related to your menstrual cycle, PMDD is a strong possibility.
  • Typical Treatments: Treatment often includes lifestyle changes, dietary adjustments, and sometimes medications like antidepressants or hormonal treatments. Cognitive-behavioral therapy (CBT) can also be beneficial.

2. Hypothyroidism

  • Rationale: Despite your thyroid levels being normal, the combination of weight gain, dry skin, feeling unusually cold, and fatigue could still suggest a mild form of hypothyroidism or subclinical hypothyroidism. Sometimes, symptoms can appear even when lab results are within the normal range.
  • Typical Treatments: If hypothyroidism is confirmed, treatment usually involves thyroid hormone replacement therapy. Regular monitoring of thyroid levels is also essential.

3. Hormonal Imbalance

  • Rationale: Hormonal imbalances can cause a variety of symptoms, including mood swings, weight gain, and changes in menstrual cycles. Given your history of having your fallopian tubes removed, it's possible that hormonal changes are contributing to your symptoms.
  • Typical Treatments: Hormonal imbalances can be managed through lifestyle changes, medications, and sometimes hormone replacement therapy. A healthcare provider may recommend blood tests to check hormone levels.

What you can do

Mood Swings and Menstrual Irregularities

  • Consult a Healthcare Provider: It's important to consult a healthcare provider to discuss your symptoms in detail. They may recommend blood tests to check for hormonal imbalances or other underlying conditions.
  • Lifestyle Changes: Regular exercise, a balanced diet, and adequate sleep can help manage mood swings. Mindfulness practices like yoga and meditation can also be beneficial.
  • Track Symptoms: Use MDandMe to journal your symptoms, track your menstrual cycle, and note any patterns. This information can be valuable for your healthcare provider.

Fatigue and Sleepiness

  • Consult a Healthcare Provider: Persistent fatigue and sleepiness should be evaluated by a healthcare provider to rule out conditions like sleep apnea, anemia, or other underlying issues.
  • Healthy Sleep Habits: Ensure you have a consistent sleep schedule, a comfortable sleep environment, and avoid caffeine or heavy meals before bedtime.
  • Stay Active: Regular physical activity can help improve energy levels and reduce fatigue.

Weight Gain and Dry Skin

  • Diet and Exercise: A balanced diet rich in fruits, vegetables, whole grains, and lean proteins, along with regular exercise, can help manage weight.
  • Skin Care: Use moisturizers to manage dry skin and stay hydrated by drinking plenty of water.
  • Consult a Healthcare Provider: If weight gain and dry skin persist, consult a healthcare provider for further evaluation and possible treatment options.

What you should look out for

Given the complexity of your symptoms, it's important to seek medical care to get a comprehensive evaluation. Here are some reasons to seek care more urgently:

  • Severe Mood Changes: If your mood swings become more severe or you experience thoughts of self-harm, seek immediate medical attention.
  • Significant Weight Changes: Rapid or unexplained weight gain or loss should be evaluated by a healthcare provider.
  • Worsening Fatigue: If your fatigue worsens or you experience other symptoms like shortness of breath or chest pain, seek medical attention.

Remember, while I can provide information and suggestions, it's crucial to consult with a healthcare provider for a formal diagnosis and appropriate treatment. Use MDandMe to journal your symptoms, track your progress, and share your medical notes with your provider.

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3 mo ago


People Also Ask


What is Premenstrual Dysphoric Disorder (PMDD) and how is it different from PMS?

PMDD is a severe form of premenstrual syndrome (PMS) that causes significant mood swings, irritability, and other emotional symptoms in the luteal phase of the menstrual cycle. Unlike PMS, PMDD symptoms are more intense and can interfere with daily life.


Can you have symptoms of hypothyroidism even if your thyroid levels are normal?

Yes, it's possible to experience symptoms of hypothyroidism even if thyroid levels are within the normal range. This condition is sometimes referred to as subclinical hypothyroidism, where symptoms appear despite normal lab results.


How can hormonal imbalances affect mood and menstrual cycles?

Hormonal imbalances can lead to mood swings, weight gain, and changes in menstrual cycles due to fluctuations in hormones like estrogen and progesterone. These imbalances can affect emotional and physical well-being.


What lifestyle changes can help manage mood swings and fatigue?

Lifestyle changes such as regular exercise, a balanced diet, adequate sleep, and mindfulness practices like yoga and meditation can help manage mood swings and fatigue. Tracking symptoms and maintaining a healthy routine are also beneficial.


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