[32M] Experiencing urethral pain post unprotected sexual encounter

Patient Description

A 32-year-old male presents with a four-week history of intermittent, dull, burning urethral pain. The onset of symptoms occurred five days following unprotected sexual intercourse. The patient has tested negative for sexually transmitted diseases (STDs) and urinary tract infections (UTIs). There is no reported penile discharge, fever, or lower back pain, but some urinary frequency and urgency are noted. The patient has been on Tavin EM (Tenofovir Disoproxil Fumarate / Emtricitabine) for HIV pre-exposure prophylaxis (PrEP) for three years and occasionally takes Tylenol for pain relief. No known drug allergies, no other medications, and no chronic health issues have been reported.

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Arora's Assessment

What might be happening

Based on the information you've provided, possible diagnoses include:

  • Urethritis: This is inflammation of the urethra, often caused by bacterial or viral infections. Even though you've tested negative for STDs and UTIs, it's possible that the infection is caused by an organism that wasn't included in the tests. Urethritis can cause burning pain, increased urinary frequency, and urgency.

    • Treatment typically involves antibiotics to clear the infection.
  • Prostatitis: This is inflammation or infection of the prostate gland. It can cause pain in the penis, increased urinary frequency, and urgency. However, it's usually accompanied by other symptoms like lower back pain or fever, which you haven't reported.

    • Treatment typically involves antibiotics and possibly other medications to manage symptoms.
  • Interstitial cystitis (IC): Also known as painful bladder syndrome, IC can cause pain in the penis, increased urinary frequency, and urgency. It's a chronic condition and the cause is unknown.

    • Treatment typically involves managing symptoms and may include medications, physical therapy, and possibly surgery in severe cases.
  • Side effects from Tavin EM (Tenofovir Disoproxil Fumarate / Emtricitabine): While rare, some people taking this medication have reported urinary symptoms. However, it's unlikely that this is the cause of your symptoms since you've been taking it for three years without issue.

What you can do

  1. Consult a healthcare professional: Given the duration and nature of your symptoms, it's important to seek medical attention. A healthcare professional can provide a formal diagnosis and appropriate treatment.

  2. Maintain good hygiene: Keeping the genital area clean can help prevent further irritation or infection.

  3. Avoid irritants: Certain soaps, lotions, and other products can irritate the urethra. Try to identify and avoid any potential irritants.

  4. Stay hydrated: Drinking plenty of fluids can help flush out any potential irritants or infectious agents.

What you should look out for

  • If your symptoms worsen or persist despite treatment
  • If you develop new symptoms, such as fever, lower back pain, or discharge from the penis
  • If you have difficulty urinating or notice blood in your urine

Please remember that while I strive to provide accurate information, I am not a doctor. You should seek care from a healthcare professional for a formal diagnosis and treatment.

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10 mo ago

People Also Ask


What are the common causes of urethral pain if STDs and UTIs are ruled out?

Common causes of urethral pain when STDs and UTIs are ruled out include non-infectious urethritis, prostatitis, interstitial cystitis, or irritation from products or activities. It's important to consult a healthcare provider for further evaluation.


Can long-term use of HIV PrEP medications like Tavin EM cause urinary symptoms?

While rare, some individuals on long-term HIV PrEP medications like Tavin EM may experience urinary symptoms. However, if these symptoms appear after years of use, other causes should be considered and discussed with a healthcare provider.


What lifestyle changes can help manage symptoms of interstitial cystitis?

Lifestyle changes to manage interstitial cystitis include avoiding foods and drinks that irritate the bladder, practicing stress-reduction techniques, and maintaining a regular schedule for urination. Consulting a healthcare provider for personalized advice is recommended.


How can prostatitis be diagnosed if typical symptoms like fever or back pain are absent?

Prostatitis can be diagnosed through a combination of patient history, physical examination, and tests such as urinalysis, prostate fluid analysis, or imaging studies. Even in the absence of typical symptoms like fever or back pain, a healthcare provider can help determine the presence of prostatitis.


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