[31F] Experiencing unexplained weight loss and gastrointestinal symptoms

Patient Description

A 31-year-old female presents with a significant unexplained weight loss of 94 pounds over 14 months, constant crampy stomach pain located above and behind the belly button radiating to the back, and persistent nausea with early satiety. She also reports extreme fatigue, cognitive impairment described as 'brain fog,' and night sweats severe enough to drench pajamas and sheets, alongside a persistent feeling of cold in hands and feet during the day. The patient has a history of ovarian cyst removal and has hemorrhaged twice within a year. She has an allergy to penicillin but is not currently on any medications.

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Arora's Assessment

What might be happening

Based on the information you've provided, here are a few possible conditions that could explain your symptoms:

  • Gastrointestinal disorders: Conditions such as peptic ulcer disease, gastritis, or gallstones can cause chronic stomach pain and nausea. These conditions can also affect your appetite, leading to unintentional weight loss.

    • Treatment typically involves medications to reduce stomach acid and inflammation, dietary modifications, and in some cases, surgery.
  • Malabsorption disorders: Conditions like celiac disease or pancreatic insufficiency can cause weight loss, stomach pain, and changes in bowel movements. They can also lead to malnutrition, which might explain your fatigue and brain fog.

    • Treatment usually involves dietary modifications and supplements to replace the nutrients your body isn't absorbing properly.
  • Endocrine disorders: Conditions such as hyperthyroidism or adrenal insufficiency can cause symptoms like weight loss, stomach pain, and increased sweating. They can also affect your body's ability to regulate temperature, which might explain why you often feel cold.

    • Treatment typically involves medications to correct the hormonal imbalance.
  • Infections: Certain infections, such as tuberculosis or HIV, can cause chronic symptoms like weight loss, night sweats, and fatigue.

    • Treatment usually involves antibiotics or antiviral medications.
  • Cancer: Although less likely, some types of cancer can cause symptoms like weight loss, stomach pain, night sweats, and fatigue. They can also cause changes in cognitive function and libido.

    • Treatment typically involves surgery, radiation, chemotherapy, or a combination of these.

What you can do

Given the range and severity of your symptoms, it's important that you seek medical attention as soon as possible. Your doctor can perform a physical examination and order tests to help determine the cause of your symptoms.

What you should look out for

You should seek immediate medical attention if you experience any of the following:

  • Severe abdominal pain
  • Blood in your stool or vomit
  • Severe or worsening fatigue
  • Confusion or difficulty staying awake
  • Rapid heart rate or shortness of breath

Remember, this advice is intended to be general in nature, and specific causes may not apply to your situation. Always consult with a healthcare provider for appropriate examination, testing, and care recommendations.

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11 mo ago

People Also Ask


What could cause significant unexplained weight loss and stomach pain?

Significant unexplained weight loss and stomach pain can be caused by various conditions, including gastrointestinal disorders, malabsorption disorders, endocrine disorders, infections, and, in rare cases, cancer. Each of these conditions affects the body differently, leading to symptoms like pain, nausea, and changes in appetite.


How can malabsorption disorders affect overall health?

Malabsorption disorders, such as celiac disease or pancreatic insufficiency, can lead to poor absorption of nutrients, resulting in weight loss, fatigue, and cognitive issues like brain fog. They can also cause deficiencies in essential vitamins and minerals, impacting overall health and well-being.


What are the common symptoms of endocrine disorders like hyperthyroidism?

Common symptoms of endocrine disorders like hyperthyroidism include weight loss, increased sweating, rapid heartbeat, anxiety, and difficulty regulating body temperature. These symptoms occur due to an overproduction of thyroid hormones, which accelerates the body's metabolism.


When should someone seek immediate medical attention for abdominal symptoms?

Immediate medical attention should be sought if someone experiences severe abdominal pain, blood in stool or vomit, severe or worsening fatigue, confusion, difficulty staying awake, rapid heart rate, or shortness of breath. These symptoms could indicate a serious underlying condition that requires prompt evaluation and treatment.


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