[29F] Experiencing extreme fatigue and dry cough

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Patient Description

A 29-year-old female has been experiencing extreme fatigue for the past month, which has gradually worsened and affects her all day, every day. This fatigue has led to a loss of motivation, and she finds herself wanting to nap frequently, although the naps do not seem to help. She has also been dealing with a dry cough and shortness of breath when she breathes deeply, which she describes as moderate in severity. Additionally, she has been under significant stress due to relationship issues and a cross-country move. The patient has lost 15 pounds since July and is currently taking Ozempic, which has caused some side effects like diarrhea and nausea. She also reported experiencing night sweats but no chest pain, tightness, wheezing, fever, chills, or swollen lymph nodes. Medical history includes hypothyroidism, high blood pressure, and obesity, for which she is taking levothyroxine (75 mg daily), lisinopril (10 mg daily), and semaglutide (0.40 mg weekly). She has a family history of stroke, cancer, and psychiatric illnesses. Specifically, her dad had a stroke, her aunts on both sides had cancer, her mom has autism, her dad has ADHD, and her maternal grandmother had schizophrenia. She is allergic to penicillin. Her menstrual cycle has remained regular, and she has not noticed any changes in it over the past month. She is also taking a women's probiotic and a women's multivitamin daily.

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Arora's Assessment

What might be happening

Based on the information you've provided, here are some possible explanations for your symptoms:

Extreme Fatigue, Dry Cough, and Shortness of Breath

  1. Hypothyroidism: Since you have a history of hypothyroidism, it's possible that your thyroid hormone levels are not well-controlled, which can lead to extreme fatigue. A blood test to check your thyroid function (TSH, T3, T4) would be helpful.
  2. Side Effects of Medications: Ozempic (semaglutide) can cause gastrointestinal symptoms like nausea and diarrhea, which might contribute to your fatigue. Additionally, rapid weight loss can sometimes lead to fatigue.
  3. Respiratory Issues: The dry cough and shortness of breath could be related to a respiratory condition such as asthma, bronchitis, or even a mild form of COVID-19. Given the duration and nature of your symptoms, a chest X-ray or pulmonary function tests might be warranted.

Night Sweats

  1. Infections: Night sweats can be a symptom of various infections, including tuberculosis or other respiratory infections.
  2. Hormonal Imbalances: Although your menstrual cycle is regular, hormonal fluctuations can sometimes cause night sweats.
  3. Medications: Some medications, including those for high blood pressure, can cause night sweats as a side effect.

Weight Loss

  1. Ozempic: This medication is known to cause weight loss, which is likely contributing to your recent weight changes.
  2. Underlying Conditions: Significant, unintentional weight loss can sometimes be a sign of underlying conditions such as hyperthyroidism, diabetes, or even malignancies.

What you can do

Extreme Fatigue, Dry Cough, and Shortness of Breath

  • Consult Your Doctor: Given the combination of symptoms, it's important to consult your healthcare provider. They may recommend blood tests to check your thyroid function and other relevant markers.
  • Medication Review: Discuss the side effects of your current medications with your doctor. They may adjust your dosage or switch medications if necessary.
  • Stay Hydrated: Ensure you are drinking plenty of fluids, especially if you are experiencing diarrhea.
  • Rest: Allow yourself to rest and avoid strenuous activities until you have a clearer understanding of what is causing your symptoms.

Night Sweats

  • Monitor Symptoms: Keep a journal of your symptoms, including the frequency and severity of your night sweats. This can help your doctor in diagnosing the issue.
  • Cool Environment: Ensure your sleeping environment is cool and well-ventilated. Wearing lightweight, breathable clothing can also help.

Weight Loss

  • Nutritional Support: Ensure you are eating a balanced diet to support your overall health. If you are struggling to maintain your weight, consider consulting a nutritionist.
  • Regular Monitoring: Keep track of your weight and any other symptoms you experience. This information can be valuable for your healthcare provider.

What you should look out for

Given the severity and combination of your symptoms, you should seek medical care as soon as possible. Reasons to seek care even more urgently include:

  • Worsening Shortness of Breath: If you find it increasingly difficult to breathe, seek immediate medical attention.
  • Chest Pain or Tightness: Although you haven't experienced this yet, it's important to be vigilant.
  • Severe Diarrhea or Dehydration: If your gastrointestinal symptoms worsen, you may need medical intervention.
  • Persistent or Worsening Symptoms: If your symptoms do not improve or continue to worsen, consult your healthcare provider.

Remember, while I can provide information and suggestions, it's crucial to consult a healthcare professional for a formal diagnosis and treatment plan. You can also use MDandMe to journal your symptoms, track progress, get insights, and share longitudinal medical notes with your provider.

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4 mo ago

People Also Ask


Can hypothyroidism cause extreme fatigue and how can it be managed?

Yes, hypothyroidism can cause extreme fatigue as it affects the body's metabolism. Managing it involves regular monitoring of thyroid hormone levels and adjusting medication like levothyroxine as needed. Consult your doctor for a blood test to check your thyroid function.


What are the common side effects of Ozempic and how might they contribute to fatigue?

Common side effects of Ozempic include nausea, diarrhea, and weight loss, which can contribute to fatigue. Discuss with your doctor if these side effects are severe, as they may adjust your dosage or suggest alternatives.


What could be causing my dry cough and shortness of breath?

A dry cough and shortness of breath could be due to respiratory conditions like asthma, bronchitis, or even a mild form of COVID-19. It's important to consult a healthcare provider for a proper diagnosis, which may include a chest X-ray or pulmonary function tests.


Why am I experiencing night sweats and should I be concerned?

Night sweats can be caused by infections, hormonal imbalances, or side effects of medications. While they can be concerning, monitoring the frequency and severity can help your doctor determine the cause. If they persist, seek medical advice.


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1 Comments


Arora (Bot)#28060

4 mo ago

It seems like you might want some clarification on your assessment. Could you please specify which part of the assessment or medical note you have questions about? For example, are you curious about the possible explanations for your symptoms, the recommended actions, or something else?

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