[28F] With mouth sores, fatigue, and joint pain

Patient Description

A 28-year-old female presents with mouth sores, fatigue, and joint pain. The mouth sores started approximately 6 months ago, appearing in clusters of 3-8, white and painful, lasting about 3-5 days, and forming continuously without specific triggers. The patient also reports fatigue and joint pain, specifically in the hips and lower back, described as aching and throbbing, with a severity of 7.5 out of 10 when severe. The pain has been occurring off and on for about a year, and a heating pad sometimes provides relief. The patient does not have a fever but experiences body aches when the mouth sores are severe. No eye inflammation or redness is reported. The patient has noticed a couple of light brown, slightly raised spots on the legs. Frequent diarrhea is also noted, which has been normal for the patient for quite a while. There is no known family history of autoimmune diseases, but some family members have thyroid issues. The patient is currently taking Effexor (300mg), Seroquel (300mg), Clonidine (0.1mg x2), Vyvanse (40mg), and birth control, all taken daily for at least 2 years. The patient has a known allergy to Amoxicillin.

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Arora's Assessment

What might be happening

Based on the symptoms you've described, here are some possible explanations:

Mouth Sores, Fatigue, and Joint Pain

  1. Autoimmune Conditions: Conditions like lupus or Behçet's disease can cause mouth sores, fatigue, and joint pain. These conditions occur when your immune system mistakenly attacks your own body.

    • Testing and Treatment: Blood tests to check for specific antibodies, inflammatory markers, and other indicators. Treatment often involves medications to reduce inflammation and suppress the immune system.
  2. Nutritional Deficiencies: Deficiencies in vitamins such as B12, folate, or iron can lead to mouth sores, fatigue, and joint pain.

    • Testing and Treatment: Blood tests to check for deficiencies. Treatment involves dietary changes and supplements.

Diarrhea and Skin Lesions

  1. Inflammatory Bowel Disease (IBD): Conditions like Crohn's disease or ulcerative colitis can cause chronic diarrhea and may also be associated with skin lesions and joint pain.

    • Testing and Treatment: Colonoscopy, blood tests, and imaging studies. Treatment often involves anti-inflammatory medications, immune system suppressors, and dietary changes.
  2. Celiac Disease: An autoimmune disorder where ingestion of gluten leads to damage in the small intestine, causing diarrhea and sometimes skin rashes.

    • Testing and Treatment: Blood tests and a biopsy of the small intestine. Treatment involves a strict gluten-free diet.

Unifying Diagnosis

  • Systemic Lupus Erythematosus (SLE): This autoimmune disease can cause a wide range of symptoms, including mouth sores, fatigue, joint pain, skin lesions, and gastrointestinal issues.
    • Testing and Treatment: Blood tests for specific antibodies, urine tests, and imaging studies. Treatment often involves anti-inflammatory medications, immune system suppressors, and lifestyle changes.

What you can do

Mouth Sores, Fatigue, and Joint Pain

  • See a Doctor: It's important to consult a healthcare provider to get a proper diagnosis and treatment plan. They may refer you to a specialist like a rheumatologist.
  • Home Care:
    • Use a heating pad to alleviate joint pain.
    • Maintain a balanced diet rich in vitamins and minerals.
    • Keep a symptom journal using MDandMe to track your symptoms and share with your healthcare provider.

Diarrhea and Skin Lesions

  • See a Doctor: Chronic diarrhea and new skin lesions should be evaluated by a healthcare provider. They may recommend tests to rule out conditions like IBD or celiac disease.
  • Home Care:
    • Stay hydrated by drinking plenty of fluids.
    • Avoid foods that trigger diarrhea.
    • Use over-the-counter creams to soothe skin lesions.

What you should look out for

Given the complexity and severity of your symptoms, you should seek medical care as soon as possible. Reasons to seek care even more urgently include:

  • Severe abdominal pain or blood in your stool.
  • Unexplained weight loss.
  • New or worsening skin lesions.
  • Severe joint pain or swelling.

Remember, while I can provide information and suggestions, it's crucial to consult a healthcare provider for a formal diagnosis and treatment plan. If you have more questions or need further assistance, feel free to continue the conversation.

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6 mo ago

People Also Ask


What could be causing my mouth sores, fatigue, and joint pain?

Mouth sores, fatigue, and joint pain can be caused by autoimmune conditions such as lupus or Behçet's disease, or by nutritional deficiencies in vitamins like B12, folate, or iron. It's important to consult a healthcare provider for proper diagnosis and treatment.


How are inflammatory bowel diseases diagnosed and treated?

Inflammatory bowel diseases like Crohn's disease or ulcerative colitis are diagnosed through colonoscopy, blood tests, and imaging studies. Treatment often involves anti-inflammatory medications, immune system suppressors, and dietary changes.


What are the symptoms and treatment options for systemic lupus erythematosus (SLE)?

Systemic lupus erythematosus (SLE) is an autoimmune disease that can cause symptoms such as mouth sores, fatigue, joint pain, skin lesions, and gastrointestinal issues. It is diagnosed through blood tests for specific antibodies, urine tests, and imaging studies. Treatment typically involves anti-inflammatory medications, immune system suppressors, and lifestyle changes.


Can nutritional deficiencies cause symptoms like mine, and how are they diagnosed?

Nutritional deficiencies, such as those in B12, folate, or iron, can cause symptoms like mouth sores, fatigue, and joint pain. They are diagnosed through blood tests, and treatment involves dietary changes and supplements.


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