[28F] Experiencing aching leg pain and fever

Patient Description

A 28-year-old female presents with a 2-day history of aching pain in the thigh, rated 8/10 in severity, which is constant and exacerbated by walking. The pain is described as being spread all over the thigh and began suddenly. Additionally, the patient reports a fever of 1.5 days duration, also rated 8/10 in severity, accompanied by a lack of energy. The fever has been confirmed not to be related to COVID-19. The thigh feels warm to the touch, but there is no redness or swelling. The patient denies any recent injuries, shortness of breath, chest pain, or other symptoms. There is no known history of chronic illnesses, allergies, or adverse reactions to medications. The patient has been taking Tylenol to manage the fever and pain.

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Arora's Assessment

What might be happening

Based on the information you've provided, possible diagnoses include:

  • Muscular Strain or Sprain: Overuse or injury to the muscles, ligaments, and tendons in your thigh can cause pain, swelling, and difficulty moving the affected area.

    • Treatment typically involves rest, ice, compression, and elevation (RICE). Over-the-counter pain relievers can also help.
  • Infection: An infection can cause fever, fatigue, and localized warmth. This could be a skin infection (cellulitis) or a deeper infection (abscess or osteomyelitis).

    • Treatment involves antibiotics, and in some cases, surgical drainage.
  • Deep Vein Thrombosis (DVT): A blood clot in a deep vein, usually in the legs. This can cause pain, swelling, and warmth over the affected area. The risk of DVT increases with prolonged periods of immobility.

    • Treatment involves anticoagulant medications.
  • Inflammatory Conditions: Conditions such as rheumatoid arthritis or lupus can cause joint pain and fever.

    • Treatment involves anti-inflammatory medications and disease-modifying antirheumatic drugs (DMARDs).

What you can do

  1. Rest and elevate your leg. Try not to put weight on it.
  2. Apply a cold pack to the area for 15 minutes at a time to help reduce inflammation.
  3. Continue taking over-the-counter pain relievers as directed on the package.
  4. Stay hydrated and eat nutritious meals to help your body fight off potential infections.

What you should look out for

Seek immediate medical attention if:

  • Your pain or fever worsens or does not improve with rest and over-the-counter medications.
  • You notice redness, swelling, or a rash in the area that's in pain.
  • You develop new symptoms, such as shortness of breath, chest pain, or confusion.

Remember, this advice is intended to be general in nature, and specific causes may not apply to your situation. Always consult with a healthcare provider for accurate information.

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10 mo ago

People Also Ask


What could cause sudden thigh pain and fever without any injury?

Sudden thigh pain and fever without any injury could be due to a muscular strain, an infection such as cellulitis or a deeper infection, or a blood clot like deep vein thrombosis (DVT). Inflammatory conditions could also be a cause.


How can I differentiate between a muscle strain and a more serious condition like an infection or DVT?

A muscle strain typically involves pain and difficulty moving the affected area, often following physical activity or overuse. An infection might present with fever, warmth, and possibly redness or swelling. DVT often causes pain, warmth, and swelling, and is more serious, requiring immediate medical attention.


What are the initial steps I should take at home if I experience similar symptoms?

Initial steps include resting and elevating the leg, applying a cold pack to reduce inflammation, and taking over-the-counter pain relievers. Staying hydrated and eating nutritious meals can also help.


When should I seek medical attention for thigh pain and fever?

Seek medical attention if the pain or fever worsens or does not improve with rest and medication, if you notice redness, swelling, or a rash, or if you develop new symptoms like shortness of breath or chest pain.


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