[27F] With chronic gastrointestinal symptoms and irritability

Patient Description

A 27-year-old female presents with a 6-month history of chronic gastrointestinal symptoms, including persistent diarrhea occurring at least twice daily, predominantly liquid in consistency with regular brown color and significant gas. The patient reports abdominal pain located in the upper middle area below the rib cage and the lower left area above the hip bone, described as dull and cramping, sometimes sharp, with a severity of 7 out of 10 at its worst. The pain is not relieved by any measures. The patient also experiences a loss of appetite, feeling a hollowness in the upper abdominal area, leading to discomfort and nausea upon eating, resulting in unintentional weight loss. Fatigue and irritability are significant, with irritability manifesting as anger triggered by noise, messes, or challenges, accompanied by chest tightness, hand shaking, and brain fog. Additionally, the patient reports a persistent eye twitch for at least a year, described as a quick flutter lasting a few seconds and recurring over 1 to 2 days. Other symptoms include bloating and heartburn. The patient has a history of celiac disease diagnosed 8 years ago, anxiety, and ADHD. There are no known allergies, and the patient is not currently taking any medications. The patient uses marijuana and vapes. Family history includes heart disease, panic attacks, OCD, and cancer.

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Arora's Assessment

What might be happening

Based on the symptoms you've described, there are a few potential diagnoses that could explain your condition:

  1. Irritable Bowel Syndrome (IBS):

    • Rationale: IBS is a common disorder that affects the large intestine and can cause symptoms like diarrhea, abdominal pain, bloating, and changes in bowel habits. Your symptoms of alternating diarrhea, abdominal pain, and bloating are consistent with IBS.
    • Typical Treatments/Testing: Diagnosis is often based on symptoms and ruling out other conditions. Treatment may include dietary changes, stress management, and medications to manage symptoms.
  2. Celiac Disease:

    • Rationale: Given your history of celiac disease, it's possible that your symptoms are related to gluten exposure. Celiac disease can cause symptoms like diarrhea, abdominal pain, weight loss, and fatigue.
    • Typical Treatments/Testing: Blood tests and a biopsy of the small intestine can confirm the diagnosis. The primary treatment is a strict gluten-free diet.
  3. Inflammatory Bowel Disease (IBD):

    • Rationale: Conditions like Crohn's disease or ulcerative colitis can cause chronic diarrhea, abdominal pain, weight loss, and fatigue. These conditions are more serious and require medical management.
    • Typical Treatments/Testing: Diagnosis may involve blood tests, stool tests, colonoscopy, and imaging studies. Treatment often includes medications to reduce inflammation and manage symptoms.
  4. Anxiety and Stress-Related Disorders:

    • Rationale: Your history of anxiety and ADHD, along with symptoms like irritability, fatigue, and eye twitching, suggest that stress and anxiety could be contributing to your gastrointestinal symptoms.
    • Typical Treatments/Testing: Management may include therapy, stress reduction techniques, and medications for anxiety.

What you can do

For Diarrhea and Abdominal Pain:

  • Dietary Changes: Consider following a low FODMAP diet, which can help reduce symptoms of IBS. Avoid foods that trigger your symptoms, such as gluten if you have celiac disease.
  • Hydration: Drink plenty of fluids to stay hydrated, especially when experiencing diarrhea.
  • Probiotics: Consider taking probiotics, which can help balance the gut microbiome and improve symptoms.
  • Consult a Doctor: See a gastroenterologist for further evaluation and management. They may recommend tests to rule out conditions like IBD or confirm celiac disease.

For Fatigue and Weight Loss:

  • Balanced Diet: Ensure you're eating a balanced diet with adequate nutrients. Small, frequent meals may be easier to tolerate.
  • Rest: Prioritize rest and avoid overexertion. Fatigue can be exacerbated by physical and mental stress.
  • Consult a Doctor: Unintentional weight loss and persistent fatigue warrant a thorough evaluation by a healthcare provider.

For Irritability and Eye Twitching:

  • Stress Management: Practice stress-reduction techniques such as deep breathing, meditation, or yoga.
  • Adequate Sleep: Ensure you're getting enough sleep, as fatigue can worsen irritability and eye twitching.
  • Consult a Doctor: Discuss your symptoms with a healthcare provider, who may recommend therapy or medications to manage anxiety and ADHD.

For Bloating and Heartburn:

  • Dietary Adjustments: Avoid foods and drinks that trigger bloating and heartburn, such as spicy foods, caffeine, and carbonated beverages.
  • Over-the-Counter Medications: Antacids or other medications may help relieve heartburn.
  • Consult a Doctor: Persistent bloating and heartburn should be evaluated by a healthcare provider to rule out underlying conditions.

General Tips:

  • Symptom Journal: Use MDandMe to journal your symptoms, track progress, and get insights. This can help you and your healthcare provider identify patterns and triggers.
  • Regular Check-Ups: Regular follow-ups with your healthcare provider are important to monitor your condition and adjust treatment as needed.

What you should look out for

Given the severity and duration of your symptoms, it's important to seek medical care. Reasons to seek care more urgently include:

  • Severe Abdominal Pain: If the pain becomes severe or unmanageable.
  • Blood in Stool: If you notice any blood in your stool.
  • Severe Weight Loss: Continued unintentional weight loss.
  • Severe Fatigue: If fatigue becomes debilitating.
  • New or Worsening Symptoms: Any new or worsening symptoms should be evaluated by a healthcare provider.

Remember, while I can provide information and suggestions, it's important to consult with a healthcare professional for a formal diagnosis and treatment plan. If you have more questions or need further assistance, feel free to continue

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6 mo ago

People Also Ask


What are the common symptoms of Irritable Bowel Syndrome (IBS)?

Common symptoms of IBS include abdominal pain, bloating, diarrhea, constipation, and changes in bowel habits. These symptoms can vary in intensity and may be triggered by certain foods or stress.


How can celiac disease affect someone who has been diagnosed with it?

Celiac disease can cause symptoms such as diarrhea, abdominal pain, bloating, weight loss, and fatigue when gluten is consumed. It is an autoimmune disorder where the ingestion of gluten leads to damage in the small intestine.


What are the differences between IBS and Inflammatory Bowel Disease (IBD)?

IBS is a functional gastrointestinal disorder characterized by symptoms like abdominal pain and altered bowel habits without any visible signs of damage in the digestive tract. IBD, which includes Crohn's disease and ulcerative colitis, involves chronic inflammation of the digestive tract and can cause more severe symptoms, including bleeding and weight loss.


Can anxiety and stress cause physical symptoms like gastrointestinal issues?

Yes, anxiety and stress can manifest as physical symptoms, including gastrointestinal issues like diarrhea, abdominal pain, and bloating. Stress can affect the gut-brain axis, leading to or exacerbating these symptoms.


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