[26F] Experiencing recurrent rectal bleeding associated with NSAID use

Patient Description

A 26-year-old female presents with recurrent rectal bleeding, described as bright red and more significant when taking ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID). The episodes occur a few times every few months and consistently with NSAID use, at a dose of 200 mg 1-2 times a month. The patient has been experiencing these symptoms on and off for the past few years. No associated symptoms such as dizziness, changes in bowel habits, or abdominal pain were reported. The patient's medication regimen includes Lexapro 20 mg daily, Vitamin D 2000 IU daily, Wellbutrin 300 mg daily, Adderall XR 10 mg daily, and Adderall 10 mg daily, with no side effects noted. There is a family history of Celiac disease but no personal history of chronic gastrointestinal conditions or allergies to medications.

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Arora's Assessment

What might be happening

Based on the information you've provided, the most likely causes of your rectal bleeding could be:

  • Hemorrhoids: These are swollen veins in the lower part of the anus and rectum. When the walls of these vessels are stretched, they may become irritated and bleed. Bright red blood in the stool or on toilet paper after a bowel movement is a common symptom of hemorrhoids. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can exacerbate bleeding from hemorrhoids.

    • Treatment typically involves over-the-counter creams or suppositories, lifestyle changes (like eating a high-fiber diet and drinking plenty of water), or in more severe cases, medical procedures.
  • Anal fissures: These are small tears in the lining of the anus, which can cause pain and bleeding during bowel movements. NSAIDs can also exacerbate bleeding from anal fissures.

    • Treatment typically involves topical creams to relax the muscle around the anus (sphincter), increasing fiber in the diet, and ensuring good hygiene in the anal area.
  • Gastrointestinal bleeding: This is bleeding that occurs in any part of the gastrointestinal tract, which includes the esophagus, stomach, small intestine, large intestine, rectum, and anus. NSAIDs like ibuprofen can cause or worsen gastrointestinal bleeding.

    • Treatment depends on the cause and may include stopping the use of NSAIDs, endoscopy to stop the bleeding, or surgery in severe cases.

Please note that while these are possible causes, only a healthcare professional can provide a definitive diagnosis.

What you can do

  1. Stop taking ibuprofen: Given the association between your use of ibuprofen and the onset of rectal bleeding, it would be advisable to stop taking ibuprofen and see if your symptoms improve. However, you should consult with a healthcare professional before stopping any medication.

  2. Increase your fiber intake: Eating a diet high in fiber can help prevent constipation and reduce the strain during bowel movements, which can help prevent rectal bleeding.

  3. Stay hydrated: Drinking plenty of water can also help prevent constipation and reduce strain during bowel movements.

  4. Over-the-counter treatments: If you suspect your rectal bleeding is due to hemorrhoids, over-the-counter creams or suppositories may provide some relief. However, these should not be used as a substitute for seeking medical attention.

What you should look out for

Please seek immediate medical attention if you experience any of the following:

  • Severe abdominal pain
  • Dizziness, lightheadedness, or fainting
  • Rapid heart rate or shortness of breath
  • Blood in your stool that is dark or mixed within the stool
  • Unintentional weight loss

Remember, while I strive to provide accurate and helpful information, I am not a doctor. Please consult with a healthcare professional for a formal diagnosis and treatment.

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1 yr ago

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People Also Ask


Can NSAIDs like ibuprofen cause rectal bleeding?

Yes, NSAIDs like ibuprofen can cause or exacerbate rectal bleeding. They can irritate the gastrointestinal tract and increase the risk of bleeding, especially if there are existing conditions like hemorrhoids or anal fissures.


What are the common symptoms of hemorrhoids?

Common symptoms of hemorrhoids include bright red blood on toilet paper or in the toilet bowl after a bowel movement, itching or irritation in the anal region, pain or discomfort, swelling around the anus, and a lump near the anus, which may be sensitive or painful.


How can I prevent rectal bleeding if I have hemorrhoids or anal fissures?

To prevent rectal bleeding if you have hemorrhoids or anal fissures, increase your fiber intake to prevent constipation, stay hydrated, avoid straining during bowel movements, and consider using over-the-counter creams or suppositories for relief. It's also advisable to avoid NSAIDs if they exacerbate your symptoms.


When should I seek medical attention for rectal bleeding?

You should seek medical attention for rectal bleeding if you experience severe abdominal pain, dizziness, lightheadedness, fainting, rapid heart rate, shortness of breath, blood in your stool that is dark or mixed within the stool, or unintentional weight loss.


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