[25M] Experiencing leg pain, fatigue, and headaches

Patient Description

A 25-year-old male presents with multiple symptoms including leg pain located behind the knee on the inside of the leg, described as a throbbing pain that feels like it's in the veins. This pain has been occurring intermittently for months, with episodes happening approximately 10 times a week, each lasting about 15 minutes. The pain is rated as a 6 out of 10 in severity and is exacerbated by walking, standing, and sometimes lying down. There is no associated swelling or color change, and no recent injuries have been reported. Additionally, the patient experiences daily fatigue, particularly when not consuming caffeine, and reports groin discomfort without relief from any interventions tried. Headaches have been occurring almost daily for the past few months. The patient also reports a slightly agitated throat for the past 3 days, tingling after sitting down, numbness in the feet, and muscle weakness throughout the body. There has been a recent weight gain over the past two months, with no changes in diet or fluid intake. The patient consumes 2-4 cups of coffee daily. Medical history includes HIV and COPD, both diagnosed 3 years ago. Current medications include Pepcid 20mg and Biktarvy. There are no known drug allergies.

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Arora's Assessment

What might be happening

It seems like your symptoms could be related to a few different issues. Here's a breakdown:

  1. Leg Pain and Tingling/Numbness:

    • The throbbing pain behind your knee, especially when exacerbated by walking or standing, could be related to a condition called popliteal artery entrapment syndrome or deep vein thrombosis (DVT). Both conditions can cause pain and discomfort in the leg. DVT is particularly concerning as it involves a blood clot in the deep veins, which can be serious if not treated.
    • The tingling and numbness in your feet and after sitting could be related to nerve compression or circulatory issues.
  2. Fatigue and Headaches:

    • Chronic fatigue and headaches can be symptoms of HIV itself or side effects of medications like Biktarvy. They can also be related to electrolyte imbalances or dehydration.
    • Given your history of HIV, it's important to consider opportunistic infections or other complications that might contribute to these symptoms.
  3. Groin Discomfort:

    • This could be related to muscle strain, hernia, or even referred pain from your leg issues.
  4. Throat Irritation:

    • This might be a separate issue, possibly related to allergies, acid reflux, or a viral infection.

What you can do

Leg Pain and Tingling/Numbness:

  • It's important to see a healthcare provider to rule out serious conditions like DVT. They may recommend imaging tests like an ultrasound.
  • In the meantime, try to elevate your legs when resting and avoid prolonged periods of standing or sitting.

Fatigue and Headaches:

  • Ensure you're staying hydrated and maintaining a balanced diet.
  • Keep track of your symptoms using MDandMe to identify any patterns or triggers.
  • Discuss with your doctor whether your current medications might be contributing to these symptoms.

Groin Discomfort:

  • Avoid heavy lifting or activities that strain the groin area.
  • If the discomfort persists, consult a healthcare provider for further evaluation.

Throat Irritation:

  • Stay hydrated and consider using a humidifier to keep your throat moist.
  • Avoid irritants like smoke or strong odors.

What you should look out for

  • Seek immediate medical attention if you experience swelling, redness, or warmth in your leg, as these could be signs of DVT.
  • If your fatigue worsens or you experience new symptoms like fever or weight loss, contact your healthcare provider.
  • Any sudden or severe changes in your symptoms should be evaluated by a healthcare professional.

Remember, while I can provide information and suggestions, it's important to consult with a healthcare provider for a formal diagnosis and treatment plan.

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1 mo ago

People Also Ask


What could be causing the throbbing pain behind my knee?

The throbbing pain behind your knee could be due to conditions like popliteal artery entrapment syndrome or deep vein thrombosis (DVT). Both can cause pain and discomfort in the leg, with DVT being particularly serious as it involves a blood clot in the deep veins.


Why am I experiencing daily fatigue and headaches?

Daily fatigue and headaches can be symptoms of HIV itself, side effects of medications like Biktarvy, or related to electrolyte imbalances or dehydration. It's important to consider these factors, especially given your medical history.


What might be the reason for my groin discomfort?

Groin discomfort could be related to muscle strain, a hernia, or referred pain from leg issues. It's advisable to avoid activities that strain the groin and consult a healthcare provider if the discomfort persists.


How can I alleviate my throat irritation?

To alleviate throat irritation, stay hydrated, use a humidifier to keep your throat moist, and avoid irritants like smoke or strong odors. If symptoms persist, consider consulting a healthcare provider.


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