[25F] With increased joint pain and swollen lymph node

Patient Description

A 25-year-old female has been experiencing increased joint pain in her knees, shoulders, back, trapezium, and metacarpal joints for years. The pain is described as sharp, sometimes dull and achy, and is rated as 8 out of 10 in severity. Tylenol and lidocaine provide temporary relief. She also experiences stiffness in her joints, particularly in the morning, lasting for an hour or two, and has noticed warmth in the affected joints. Additionally, she has a swollen lymph node in her armpit that has been present for almost a month. It is very painful when touched and feels hard. She also experiences headaches that are sharp or throbbing, occurring every other day to every day, and lasting all day if she doesn’t take medicine. She reports feeling tired and having a low-grade fever occasionally, along with losing weight very easily. There is no family history of autoimmune diseases, except for some kind of arthritis in her grandmother. She has not traveled recently to areas where certain infections are more common. Her past medical history includes giving birth in 2018, and she is currently using the Zafemy birth control patch for the past 3 months. She is not taking any other medications or supplements and has no known allergies to medications.

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Arora's Assessment

What might be happening

Based on the symptoms you've described, here are some possible explanations:

1. Rheumatoid Arthritis (RA)

  • Rationale: RA is an autoimmune disorder that can cause joint pain, stiffness, and swelling. The warmth in your joints, morning stiffness, and the chronic nature of your symptoms are consistent with RA.
  • Typical Treatments/Testing: Blood tests (like rheumatoid factor and anti-CCP), imaging tests (X-rays, MRI), and physical exams. Treatment often includes medications like NSAIDs, corticosteroids, DMARDs, and biologics.

2. Lymphadenopathy

  • Rationale: The swollen, painful lymph node in your armpit could be due to an infection, inflammation, or more rarely, a malignancy. Given its persistence and pain, it should be evaluated.
  • Typical Treatments/Testing: Physical examination, blood tests, imaging (ultrasound, CT scan), and possibly a biopsy to determine the cause.

Unifying Diagnosis: Systemic Lupus Erythematosus (SLE)

  • Rationale: SLE is an autoimmune disease that can affect multiple systems, including joints, skin, kidneys, and the nervous system. Your joint pain, headaches, fatigue, and occasional low-grade fever could be indicative of SLE.
  • Typical Treatments/Testing: Blood tests (ANA, anti-dsDNA), urine tests, and imaging studies. Treatment often includes NSAIDs, corticosteroids, antimalarial drugs, and immunosuppressants.

What you can do

Joint Pain and Stiffness

  • See a Rheumatologist: A specialist can provide a more accurate diagnosis and treatment plan.
  • At Home:
    • Exercise: Gentle, low-impact exercises like swimming or yoga can help maintain joint flexibility.
    • Heat and Cold Therapy: Apply heat to reduce stiffness and cold packs to reduce inflammation.
    • Over-the-Counter Pain Relief: Continue using Tylenol as needed, but consult your doctor for long-term management.

Swollen Lymph Node

  • See a Doctor: Given the duration and pain, it's important to get this evaluated to rule out infections or other serious conditions.
  • At Home:
    • Warm Compress: Applying a warm compress can help reduce pain and swelling.
    • Avoid Irritation: Try not to touch or press on the swollen lymph node.

Headaches and Fatigue

  • See a Primary Care Physician: They can help determine the underlying cause and recommend appropriate treatments.
  • At Home:
    • Hydration: Ensure you are drinking enough water throughout the day.
    • Rest: Make sure you are getting adequate sleep and rest.
    • Over-the-Counter Pain Relief: Continue using medications as needed, but consult your doctor for long-term management.

General Health

  • Healthy Lifestyle: Maintain a balanced diet, regular exercise, and avoid smoking or excessive alcohol consumption.
  • Symptom Tracking: Use MDandMe to journal your symptoms, track progress, get insights, and share longitudinal medical notes with your provider.

What you should look out for

Given the severity and chronic nature of your symptoms, you should seek medical care as soon as possible. Reasons to seek care even more urgently include:

  • New or Worsening Symptoms: Any new symptoms or worsening of existing symptoms should prompt a visit to your doctor.
  • Severe Pain or Swelling: If you experience severe pain or swelling that does not improve with home remedies.
  • Fever or Unexplained Weight Loss: Persistent fever or significant, unexplained weight loss should be evaluated by a healthcare professional.

Remember, while I can provide information and suggestions, it's important to consult with a real healthcare professional for a formal diagnosis and treatment plan.

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4 mo ago


People Also Ask


What are the common symptoms of rheumatoid arthritis?

Common symptoms of rheumatoid arthritis include joint pain, stiffness, swelling, warmth in the joints, and morning stiffness lasting more than an hour. It often affects multiple joints and can lead to joint deformity over time.


How can swollen lymph nodes be evaluated and treated?

Swollen lymph nodes can be evaluated through a physical examination, blood tests, imaging tests like ultrasound or CT scans, and sometimes a biopsy. Treatment depends on the underlying cause, which could be an infection, inflammation, or more serious conditions like cancer.


What are the potential causes of chronic headaches and fatigue?

Chronic headaches and fatigue can be caused by a variety of factors including stress, dehydration, lack of sleep, infections, or underlying conditions like migraines or autoimmune diseases. It's important to consult a healthcare provider for a proper diagnosis.


How can systemic lupus erythematosus (SLE) be diagnosed and managed?

Systemic lupus erythematosus (SLE) can be diagnosed through blood tests such as ANA and anti-dsDNA, urine tests, and imaging studies. Management typically involves medications like NSAIDs, corticosteroids, antimalarial drugs, and immunosuppressants, along with lifestyle modifications.


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