[24M] With chronic fatigue, clumpy semen, hair loss, and weight gain

Patient Description

A 24-year-old male has been experiencing constant fatigue for the past 5 years, significantly affecting his daily life and work. Despite getting around 7 hours of sleep each night, he does not feel rested upon waking and often feels like he could fall asleep at any time. The fatigue started suddenly and is not linked to any changes in diet, lifestyle, or stress levels. Additionally, he has noticed clumpy semen, which varies in severity from day to day, and hair loss along his hairline on his forehead since he was 18, resulting in thin hair and a receding hairline. Over the past 3 years, he has gained weight and has been dealing with anxiety, depression, and agitation for a while. Diagnosed with ADHD at 8 years old and with anxiety and depression around 17 years old. He has not experienced any intolerance to cold temperatures, constipation, changes in skin, or changes in libido or sexual function. Thyroid function test results were negative for any abnormalities, despite his mother having thyroid issues. He consumes alcohol occasionally and uses nicotine products daily through vaping. Currently taking 10 mg of Lexapro once a day, 300 mg of Wellbutrin once a day, 200 mg of Magnesium, and is unsure about the dosages for Glycine and Omeprazole. No allergies or adverse reactions to medications.

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Arora's Assessment

What might be happening

Based on the symptoms you've described, here are some possible explanations:

Chronic Fatigue

  • Chronic Fatigue Syndrome (CFS): Given your long-term, debilitating fatigue that doesn't improve with sleep, CFS could be a possibility. This condition is characterized by extreme tiredness that doesn't go away with rest and affects daily activities.
  • Sleep Disorders: Even though you sleep for 7 hours, conditions like sleep apnea can cause poor-quality sleep, leading to persistent fatigue.
  • Depression and Anxiety: Both of these conditions can contribute to feelings of fatigue and low energy levels.

Clumpy Semen

  • Dehydration: Sometimes, clumpy semen can be a result of dehydration. Ensuring adequate fluid intake can help.
  • Infections or Inflammation: Prostate or seminal vesicle infections can cause changes in semen consistency.

Hair Loss

  • Androgenetic Alopecia: This is a common form of hair loss in men, often referred to as male-pattern baldness. It typically affects the hairline and crown.
  • Nutritional Deficiencies: Lack of essential nutrients like iron, zinc, and vitamins can contribute to hair loss.

Weight Gain

  • Medication Side Effects: Both Lexapro and Wellbutrin can contribute to weight changes.
  • Lifestyle Factors: Reduced physical activity and dietary habits can also play a role.

Unifying Diagnoses

  • Hormonal Imbalances: Conditions like hypothyroidism can cause fatigue, weight gain, and hair loss. However, your thyroid function tests were negative.
  • Metabolic Syndrome: This includes a cluster of conditions like increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol levels, which can contribute to fatigue and weight gain.

What you can do

Fatigue

  • Consult a Healthcare Provider: Given the long duration and impact on your life, it's crucial to consult a healthcare provider for a thorough evaluation. They may recommend blood tests, sleep studies, or other diagnostic tests.
  • Lifestyle Modifications: Ensure a balanced diet, regular physical activity, and good sleep hygiene. Avoid caffeine and nicotine close to bedtime.
  • Mental Health Support: Continue with your current medications and consider therapy or counseling to manage anxiety and depression.

Clumpy Semen

  • Hydration: Ensure you are drinking enough water throughout the day.
  • Medical Consultation: If the issue persists, consult a healthcare provider to rule out infections or other underlying conditions.

Hair Loss

  • Consult a Dermatologist: A specialist can provide treatments like topical minoxidil or oral medications to slow down hair loss.
  • Nutritional Support: Ensure a diet rich in essential nutrients. Consider supplements if needed.

Weight Gain

  • Diet and Exercise: Focus on a balanced diet and regular physical activity. Even light exercise can help improve energy levels and mood.
  • Medication Review: Discuss with your healthcare provider if your current medications could be contributing to weight gain and if any adjustments are needed.

What you should look out for

  • Worsening Symptoms: If you notice any new or worsening symptoms, such as significant changes in mood, severe fatigue, or other unexplained symptoms, seek medical attention promptly.
  • Side Effects of Medications: Be aware of any side effects from your current medications and report them to your healthcare provider.
  • Severe Fatigue: If your fatigue becomes so severe that it affects your ability to perform daily activities or poses a safety risk (e.g., falling asleep while driving), seek immediate medical attention.

Remember, while I can provide information and suggestions, it's essential to consult with a healthcare provider for a formal diagnosis and treatment plan. You can also use MDandMe to journal your symptoms, track progress, get insights, and share longitudinal medical notes with your provider.

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4 mo ago


People Also Ask


What could be causing my constant fatigue despite getting enough sleep?

Constant fatigue despite adequate sleep could be due to conditions like Chronic Fatigue Syndrome, sleep disorders such as sleep apnea, or mental health issues like depression and anxiety. It's important to consult a healthcare provider for a thorough evaluation.


Why might my semen be clumpy, and should I be concerned?

Clumpy semen can sometimes be caused by dehydration or infections in the prostate or seminal vesicles. Ensuring adequate hydration and consulting a healthcare provider if the issue persists can help address the concern.


What are the common causes of hair loss in young men?

Common causes of hair loss in young men include androgenetic alopecia, also known as male-pattern baldness, and nutritional deficiencies. Consulting a dermatologist can help determine the cause and appropriate treatment.


Can my medications be contributing to my weight gain?

Yes, medications like Lexapro and Wellbutrin can contribute to weight changes. It's advisable to discuss with your healthcare provider if your medications might be affecting your weight and if any adjustments are needed.


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