[22F] With chronic nausea, diarrhea, and significant weight loss

What might be happening

Based on the information you have provided, here are some possible explanations for your symptoms:

• Gastroenteritis: This is an inflammation of the stomach and intestines, often caused by infections (viral, bacterial, or parasitic). Symptoms include nausea, vomiting, diarrhea, and abdominal pain. Treatment typically involves staying hydrated and resting. In some cases, antibiotics or other medications may be necessary.

• Irritable Bowel Syndrome (IBS): IBS is a common disorder that affects the large intestine. Symptoms include cramping, abdominal pain, bloating, gas, and diarrhea or constipation. Treatment often involves dietary changes, stress management, and medications to manage symptoms.

• Peptic Ulcer Disease: Ulcers in the stomach or the first part of the small intestine can cause nausea, vomiting, and abdominal pain. Treatment usually involves medications to reduce stomach acid and antibiotics if a bacterial infection is present.

• Gastroparesis: This condition affects the stomach muscles and prevents proper stomach emptying. Symptoms include nausea, vomiting, feeling full quickly, and weight loss. Treatment may involve dietary changes, medications, and sometimes procedures to help the stomach empty more effectively.

• Medication Side Effects: Zoloft (sertraline) can sometimes cause gastrointestinal side effects, including nausea, diarrhea, and loss of appetite. If you suspect your medication might be contributing to your symptoms, consult your healthcare provider.

What you can do

While it's important to consult a healthcare professional for a formal diagnosis and treatment plan, here are some steps you can take to manage your symptoms:

1. Stay Hydrated: Drink plenty of fluids, such as water, clear broths, or oral rehydration solutions, to prevent dehydration from diarrhea and vomiting.
2. Eat Small, Frequent Meals: Eating smaller, more frequent meals can help manage nausea and prevent feeling overly full.
3. Avoid Trigger Foods: Try to avoid foods that are spicy, fatty, or greasy, as they can exacerbate gastrointestinal symptoms.
4. Rest: Ensure you get plenty of rest to help your body recover.
5. Track Your Symptoms: Use MDandMe to journal your symptoms, track your progress, and share longitudinal medical notes with your healthcare provider. This can help identify patterns and triggers.
6. Consult Your Doctor: Schedule an appointment with your healthcare provider to discuss your symptoms and potential treatments. They may recommend tests such as blood work, stool tests, or imaging studies to determine the cause of your symptoms.

What you should look out for

Seek medical attention more urgently if you experience any of the following:

• Severe abdominal pain
• Blood in your stool or vomit
• High fever (temperature over 100.4°F)
• Signs of dehydration, such as dark urine, dizziness, or dry mouth
• Rapid weight loss without trying

Remember, while I can provide information and suggestions, I am not a substitute for a real healthcare professional. Please consult your doctor for a formal diagnosis and appropriate treatment.