[22F] Experiencing unexplained weight gain, fatigue, and nausea

Patient Description

A 22-year-old female has been experiencing a gradual weight gain totaling 35 lbs over the last 8.5 months, despite efforts to eat healthier and exercise. She also reports daily nausea occurring around 2pm, which she rates as mild in severity, and fatigue, including waking up in the middle of the night with sweating. Additionally, she has noticed hair thinning around her hairline in the past few months. The patient has a history of asthma diagnosed in early childhood but is not on any prescription medications, only taking vitamins. She has a hormonal IUD in place and has not observed changes in her skin or menstrual cycle. She also reports increased frequency of urination. No known allergies or adverse reactions to medications have been reported.

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Arora's Assessment

What might be happening

Based on the information you've provided, possible diagnoses include:

  • Hypothyroidism: This is a condition where the thyroid gland doesn't produce enough thyroid hormones. Symptoms can include fatigue, weight gain, and hair thinning.

    • Treatment typically involves daily use of the synthetic thyroid hormone levothyroxine, which restores adequate hormone levels, reversing the symptoms of hypothyroidism.
  • Polycystic Ovary Syndrome (PCOS): This is a hormonal disorder common among women of reproductive age. Symptoms can include weight gain, fatigue, and thinning hair. However, you did not mention irregular periods, which is a common symptom.

    • Treatment of PCOS may involve lifestyle modifications and medication to manage individual symptoms.
  • Cushing's Syndrome: This is a condition that occurs from exposure to high cortisol levels for a long time. Symptoms can include weight gain, fatigue, and thinning hair. However, you did not report some of the common symptoms such as a rounded face, pink or purple stretch marks, and increased body hair.

    • Treatment depends on the cause. It may involve reducing corticosteroid use, surgery, radiation, or medications.

Please note that these are possibilities and not a definitive diagnosis. It's important to consult with a healthcare provider for an accurate diagnosis.

What you can do

  1. Schedule an appointment with your healthcare provider. They can order tests to confirm a diagnosis and discuss treatment options.
  2. Keep a symptom diary. This can help your healthcare provider understand your symptoms better.
  3. Continue to maintain a healthy lifestyle. This includes eating a balanced diet, regular exercise, and getting enough sleep.

What you should look out for

  • If your symptoms worsen or if you develop new symptoms, seek medical attention immediately.
  • If you experience severe abdominal pain, vomiting, or fainting, these could be signs of a more serious condition and you should seek immediate medical attention.

Remember, this advice is intended to be general in nature, and specific causes may not apply to your situation. Always consult with a healthcare provider for accurate information.

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11 mo ago

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People Also Ask


What are the common symptoms of hypothyroidism?

Common symptoms of hypothyroidism include fatigue, weight gain, hair thinning, dry skin, sensitivity to cold, constipation, and depression. It's important to get a blood test to check thyroid hormone levels for a proper diagnosis.


How can Polycystic Ovary Syndrome (PCOS) affect weight and hair health?

PCOS can lead to weight gain due to insulin resistance and hormonal imbalances. It can also cause hair thinning or hair loss due to elevated levels of androgens. Managing PCOS often involves lifestyle changes and medications to address these symptoms.


What are the typical signs of Cushing's Syndrome?

Typical signs of Cushing's Syndrome include weight gain, particularly around the abdomen and face, a rounded face, pink or purple stretch marks, thinning skin, and increased body hair. Diagnosis usually involves blood tests to measure cortisol levels.


Why might someone experience increased urination without changes in fluid intake?

Increased urination without changes in fluid intake can be caused by several factors, including hormonal imbalances, diabetes, urinary tract infections, or certain medications. It's important to consult a healthcare provider to determine the underlying cause.


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