[21M] Experiencing chronic fatigue, headaches, and cold extremities

Patient Description

A 21-year-old male reports suffering from severe fatigue that confines him to bed most days, a chronic aching headache across the forehead, cold hands and feet with occasional tingling, crampy and achy stomach pain, and constipation. These symptoms have been present for approximately 5 years, with constipation being a more recent concern over the past 2 years. The patient has been diagnosed with POTS, RLS, depression, and anxiety roughly 4 years ago. He is currently on Lexapro (20mg) for 5 years and Amitriptyline for about 3 years, with the exact dosage of Amitriptyline not recalled. Additionally, he uses oxy powder to aid with bowel movements. No allergies or adverse reactions to medications have been reported. The patient has been under the care of doctors at the Cleveland Clinic and has no known family history of similar symptoms or related medical conditions.

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Arora's Assessment

What might be happening

Based on the information you have provided, possible diagnoses include:

  • Chronic Fatigue Syndrome (CFS): This condition is characterized by extreme fatigue that can't be explained by any underlying medical condition. The fatigue worsens with physical or mental activity, but doesn't improve with rest. This could explain your fatigue, headaches, and the fact that laying down seems to alleviate your symptoms.

    • Treatment for CFS focuses on symptom relief. This may include medication to control pain, dietary adjustments, and physical therapy.
  • Postural Orthostatic Tachycardia Syndrome (POTS): This is a condition in which a change from lying to standing causes an abnormally large increase in heart rate. This could explain your lightheadedness, fainting episodes, and palpitations.

    • Treatment for POTS may include lifestyle modifications and medications.
  • Restless Legs Syndrome (RLS): This is a condition that causes an uncontrollable urge to move your legs, usually because of an uncomfortable sensation. It typically happens in the evening or nighttime hours when you're sitting or lying down. This could explain the tingling in your feet.

    • Treatment for RLS may include lifestyle changes and medications.
  • Depression and Anxiety: These mental health disorders can cause physical symptoms such as fatigue, headaches, and stomach pain.

    • Treatment for depression and anxiety may include psychotherapy (talk therapy), medications, and lifestyle changes.

Please note that this is not a comprehensive list of all possible diagnoses. Other conditions could also explain your symptoms.

What you can do

  1. Continue to follow up with your doctors at the Cleveland Clinic. They can provide a formal assessment and order relevant tests if necessary.
  2. Keep a symptom diary. This can help you and your healthcare team understand what factors might be contributing to your symptoms. Note when your symptoms occur, what you're doing at the time, and what foods you've eaten.
  3. Practice good sleep hygiene. This includes going to bed and waking up at the same time every day, keeping your bedroom dark and quiet, and avoiding caffeine and large meals before bed.
  4. Stay hydrated and eat a balanced diet. This can help manage your symptoms and improve your overall health.

What you should look out for

Seek immediate medical attention if:

  • Your symptoms significantly worsen
  • You have difficulty breathing
  • You experience chest pain
  • You have thoughts of harming yourself or others

Remember, while I strive to provide accurate information, I'm not a doctor. Always consult with a healthcare professional for a formal diagnosis and treatment.

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10 mo ago

People Also Ask


What is Chronic Fatigue Syndrome (CFS) and how is it treated?

Chronic Fatigue Syndrome (CFS) is a complex disorder characterized by extreme fatigue that doesn't improve with rest and worsens with physical or mental activity. Treatment focuses on symptom relief and may include medications for pain, dietary changes, and physical therapy.


How does Postural Orthostatic Tachycardia Syndrome (POTS) affect the body?

Postural Orthostatic Tachycardia Syndrome (POTS) affects the autonomic nervous system, causing an excessive increase in heart rate when moving from lying down to standing. This can lead to symptoms like lightheadedness, fainting, and palpitations. Treatment often involves lifestyle changes and medications.


What are common treatments for Restless Legs Syndrome (RLS)?

Common treatments for Restless Legs Syndrome (RLS) include lifestyle changes such as regular exercise and avoiding caffeine, as well as medications that can help manage symptoms. These medications may include dopamine agonists, anticonvulsants, or opioids.


Can depression and anxiety cause physical symptoms like fatigue and headaches?

Yes, depression and anxiety can manifest as physical symptoms, including fatigue, headaches, and stomach pain. These symptoms are often part of the body's response to stress and can be managed with psychotherapy, medications, and lifestyle changes.


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