[47F] With sudden vision loss and multiple systemic symptoms

Patient Description

A 47-year-old female has been experiencing sudden vision loss for the past 7 weeks, along with a 50-pound weight loss over 2 months, loss of taste and smell (with onset 8 weeks ago), and food intolerance. She reports no bowel movements for 3-4 days at a time, pressure headaches (intensity 8/10 at worst) for the past 3 weeks, and a rash with welts on the bottoms of her feet, palms, and shins that appear and disappear within minutes, accompanied by itching and burning, for the past 6 weeks. Additionally, she has noticed personality changes, nervousness, and anxiety over the past 2 weeks. She also experiences dizziness and nausea, especially when getting up. The patient had a staph infection a couple of weeks ago. She is currently on Prozac (40 mg once daily), Gabapentin (400 mg three times a day), and Zofran. She has a history of transverse myelitis diagnosed in 2015, which is currently in remission. No known drug allergies.

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Arora's Assessment

What might be happening

It is likely that your symptoms are related to multiple issues, including existing diagnoses. If you have more questions, we can continue chatting.

Causes of your vision loss, weight loss, and changes in taste and smell:

  • Neurological Conditions: Sudden vision loss, significant weight loss, and changes in taste and smell could be related to neurological conditions. Given your history of transverse myelitis, it is important to rule out any new neurological issues.
  • Infections: Recent staph infection could potentially have systemic effects, although it is less likely to cause all these symptoms. However, infections can sometimes lead to complications that affect multiple systems.
  • Medication Side Effects: Prozac and Gabapentin can have side effects that might contribute to some of your symptoms, such as changes in taste and smell, weight loss, and dizziness.

Causes of your headaches, rash, and itching:

  • Allergic Reactions: The rash and itching that come and go could be related to an allergic reaction or a dermatological condition. The headaches with pressure could be related to sinus issues or migraines.
  • Stress and Anxiety: High levels of stress and anxiety can manifest physically, contributing to headaches, skin reactions, and other symptoms.

Causes of your personality changes, nervousness, and anxiety:

  • Medication Side Effects: Prozac, an antidepressant, can sometimes cause changes in mood and personality, as well as increased anxiety.
  • Neurological or Psychological Conditions: Changes in personality and increased anxiety could be related to underlying neurological or psychological conditions.

What you can do

Vision loss, weight loss, and changes in taste and smell:

  • See a doctor as soon as possible: These symptoms are concerning and need to be evaluated by a healthcare professional. Your doctor may order imaging studies, blood tests, and other diagnostic tests to determine the cause.
  • Monitor your symptoms: Keep a detailed record of your symptoms, including when they occur and any potential triggers. This can help your doctor in making a diagnosis.

Headaches, rash, and itching:

  • Consult a doctor: Your doctor can help determine the cause of your headaches and skin reactions. They may recommend allergy testing or refer you to a dermatologist.
  • Manage stress: Practice stress-reducing techniques such as deep breathing, meditation, or yoga. This can help alleviate some of your symptoms.
  • Over-the-counter medications: You can use over-the-counter antihistamines for itching and rash, and pain relievers for headaches, but consult your doctor before starting any new medication.

Personality changes, nervousness, and anxiety:

  • Talk to your doctor: Discuss your mood changes and anxiety with your doctor. They may adjust your medication or recommend therapy.
  • Seek support: Consider talking to a mental health professional or joining a support group to help manage your anxiety and stress.

What you should look out for

Given the severity of your symptoms and the possibility of life-threatening causes, you should seek medical care as soon as you can. Reasons to seek care even more urgently include:

  • Sudden worsening of vision or complete vision loss
  • Severe headache that doesn't improve with medication
  • New or worsening rash, especially if accompanied by fever
  • Severe dizziness or fainting
  • Unexplained bruising, bleeding, or swelling

Remember, while I can provide information and suggestions, it is crucial to consult with a healthcare professional for a formal diagnosis and appropriate treatment. You can also use MDandMe to journal your symptoms, track progress, get insights, and share longitudinal medical notes with your provider.

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3 mo ago


People Also Ask


What could be causing my sudden vision loss and weight loss?

Sudden vision loss and weight loss could be related to neurological conditions, especially given your history of transverse myelitis. It's important to see a doctor for a thorough evaluation, which may include imaging studies and blood tests.


Are my headaches and skin rash related to an allergic reaction?

Yes, your headaches and skin rash could be related to an allergic reaction or a dermatological condition. It's advisable to consult a doctor who may recommend allergy testing or refer you to a dermatologist.


Can my medications be causing changes in my mood and anxiety levels?

Yes, medications like Prozac and Gabapentin can have side effects that include changes in mood and increased anxiety. Discuss these changes with your doctor, who may adjust your medication or suggest therapy.


What should I do if my symptoms suddenly worsen?

If your symptoms suddenly worsen, such as experiencing complete vision loss, severe headaches, or new rashes with fever, seek medical care immediately. These could be signs of a serious condition that requires urgent attention.


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