[47F] Experiencing transient neurological symptoms post-thymectomy

Patient Description

A 47-year-old female reports transient bilateral eyelid drooping, difficulty swallowing, and slurred speech that began 10 months after undergoing a thymectomy. These symptoms seem to be exacerbated by fatigue and cold exposure and improve with rest. The patient has no history of myasthenia gravis, a condition commonly associated with these symptoms. Past medical history includes early-stage breast cancer treated with surgery, chemotherapy, radiation, and ongoing immunotherapy (Kanjinti every three weeks), as well as vertigo when turning the head to the left, diagnosed last June. The patient is currently on Tamoxifen 10 mg. No known allergies or other medications reported.

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Arora's Assessment

What might be happening

Based on your symptoms and medical history, the following conditions might be considered:

  • Myasthenia Gravis: This is a neuromuscular disorder that causes weakness in the skeletal muscles, which are the muscles your body uses for movement. It's characterized by weakness and rapid fatigue of any of the muscles under your voluntary control. The hallmark of myasthenia gravis is muscle weakness that increases during periods of activity and improves after periods of rest. The muscles that control eye and eyelid movement, facial expression, chewing, talking, and swallowing are often, but not always, involved. This condition can occur at any age, but it's more common in women younger than 40 and in men older than 60. It's not directly inherited or contagious, and it's not related to the thymectomy you had, but the fact that you had a thymectomy suggests you may have been evaluated for this condition before.

    • Treatment typically involves medications that help improve neuromuscular transmission and increase muscle strength, and immunosuppressive drugs are used to decrease the abnormal immune response that occurs in myasthenia gravis. In some cases, surgery to remove the thymus gland (thymectomy) is recommended.
  • Side effects of cancer treatments: Some of the treatments you've received for your breast cancer, such as chemotherapy and immunotherapy, can cause side effects that include fatigue and muscle weakness. These side effects can sometimes be mistaken for symptoms of other conditions, like myasthenia gravis.

    • Management of these side effects typically involves supportive care to alleviate symptoms, dose adjustments of your cancer treatments, or temporary discontinuation of treatment until symptoms improve.

What you can do

  1. Make an appointment with your healthcare provider to discuss your symptoms. They may want to perform some tests to determine the cause of your symptoms, such as blood tests or imaging studies.
  2. Keep a symptom diary. This can help you and your healthcare provider identify any patterns or triggers related to your symptoms.
  3. Rest and avoid overexertion. Since your symptoms seem to improve with rest, make sure you're getting enough sleep and not overdoing it during the day.

What you should look out for

Seek immediate medical attention if you experience:

  • Difficulty breathing or shortness of breath
  • Sudden worsening of your symptoms
  • New symptoms, such as muscle weakness in your arms or legs

Please remember that while I strive to provide accurate and helpful information, I am an AI and not a doctor. Always consult with a healthcare professional for a formal diagnosis and treatment.

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People Also Ask


What are the common symptoms of myasthenia gravis?

Common symptoms of myasthenia gravis include muscle weakness that worsens with activity and improves with rest, drooping eyelids, difficulty swallowing, slurred speech, and sometimes difficulty breathing. The muscles controlling eye and eyelid movement, facial expression, and swallowing are often affected.


Can cancer treatments cause symptoms similar to myasthenia gravis?

Yes, cancer treatments such as chemotherapy and immunotherapy can cause side effects like fatigue and muscle weakness, which can mimic the symptoms of myasthenia gravis. It's important to differentiate between treatment side effects and other conditions.


What is the role of the thymus gland in myasthenia gravis?

The thymus gland is involved in the immune system and is thought to play a role in myasthenia gravis by producing antibodies that interfere with neuromuscular transmission. Thymectomy, or removal of the thymus gland, is sometimes performed as a treatment for myasthenia gravis.


How can fatigue and cold exposure affect muscle weakness in myasthenia gravis?

Fatigue and cold exposure can exacerbate muscle weakness in myasthenia gravis because they can increase the demand on already weakened muscles, leading to more pronounced symptoms. Rest and avoiding cold environments can help manage these symptoms.


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